Dendritic cells ( dc ) is the most powerful apc, which can markedly increase the antigen - presentation capacity by maximizing the pepitide - mhc complexes on the cell surface and upregulating the co - stimulatory ligands b7 - 1 and b7 - 2, adhesion moleculees such as il - 12 that promote full activation of lymphocytes. full activation of antigen - specific t cells requires two signals - one signal coming via the tcr and the other signal through engagment of co - stimulatary molecules. t cells receiving one signal via their tcr are turned off by mhc ( major histocompatibility complex ), via t cell cd28 binding to b7 on the dc induce tlymphokine and t cell proliferatiion
T細胞介導的細胞免疫在控制腫瘤生長方面發揮著重要作用, t細胞在發揮抗瘤效應(分泌細胞因子和直接殺傷)之前必須先經過活化,體內專職抗原
提呈細胞( apc )細胞並使其活化,樹突狀細胞( dendriticcell , dc )為t細胞的激活
提供雙重信號, t細胞藉助tcr識別由dcmhc分子遞交的抗原肽后,通過tcr - cd3復合體傳遞抗原特異性識別信號(第一信號) ,以cd28為主的t細胞表面輔佐分子識別dc表面b7分子,傳遞非特異性協同刺激信號(第二信號) ,在機體抗腫瘤免疫應答中處于核心地位。
There's no point in submitting documents to the customs before they have the ship's manifest, would there ?
在海關沒有拿到船舶的載貨清單以前,去
提呈申報單是沒有用的,是嗎?
Your submission has been successfully received by us
我們已經成功地收到了你的
提交(內容) /
提呈。
Approves the annual business plan and budget proposed by management
批準管理人員
提呈的年度業務計劃及財政預算
The rules will also be published in the gazette and subject to negative vetting by the legislative council
上述規則亦須于憲報刊登,並
提呈立法會進行先訂立后審議的程序。
On june 8, i submitted to the chief of staff a draft of a " directive for the commanding general, european theater of operations.
6月8日,我向參謀總長
提呈一份草擬的「歐洲戰區司令指導方案。 」
A new bill was tabled in the legislative council in mid - 2005 and is being vetted by the legislative council s bills committee
環保署已於2005年中向立法會
提呈新草案,法案委員會現正就草案進行審議。
G to review the company s annual and interim financial statements before submission to the board, focusing particularly on : -
G在
提呈予董事會前審閱本公司的年度及中期財務報表,並特別針對下列事項:
These pages in or on the site should not be construed as an offer or solicitation to sell investments or make deposits in any country to any person to whom it is unlawful to make such an invitation or solicitation in such country
本網站所載的這些網頁不應被詮釋為向
提呈發售或招售屬違法的任何國家的任何人士,
提呈發售或招售投資或存款。
Dcs play a pivotal role in the development of antitumor immunity. t lymphocytes immune response induced by direct antigen - pulsed dcs can not maintain longer for peptides - mhc department or mhc molecules degeneration. the method of dcs loading with tumor antigen gene is another potential approach to enhancing and maintaining immune response
在用抗原直接刺激dc時,由於抗原- mhc復合物解離或細胞mhc分子降解而不能維持所誘導的t細胞免疫應答,藉助載體把腫瘤抗原基因導入dc后腫瘤抗原在dc內的持續表達能增強其抗原
提呈能力並能維持所誘導的免疫效應。
Dendritic cells ( dc ) are the most potent professional antigen - presenting cells ( apc ), required for the initiation of immune response. for all that the mechanism of dc functions are not fully elucidated
樹突狀細胞( dendriticcell , dc )是一種重要的專職抗原
提呈細胞( apc ) ,具有刺激初始型t細胞增殖、啟動初次免疫應答的獨特功能,是t細胞免疫應答的直接啟動者和調控者。
It delivers the false ? folding peptides for presentation to proteasomes in normal cells, while in tumor cells it acts as main tumor - resistant antigen, inducing specific immune response. recent research found that grp94 also relates with cell cycles, differentiation and apoptosis
此外發現它還具有抗原
提呈作用,在正常細胞中參與折疊錯誤蛋白到蛋白酶體的
提呈;在腫瘤細胞中作為主要的腫瘤排斥抗原,引發針對該腫瘤細胞的特異性免疫反應。
Constitutive expression of class ii mhc is restricted to " professional " antigen - presenting cells but can be induced on various tissues by gamma interferon
Mhc -類的組成型表達僅限於「專職性」抗原提呈細胞,但細胞因子如ifn -可引起誘導型類分子表達。