核苷酸類物 的英文怎麼說
中文拼音 [hésuānlèiwù]
核苷酸類物
英文
nucleotide analogue-
Fatal lactic acidosis has been reported to patients who received didanosine and other antiretroviral agents
有報道同時應用核苷類似物的患者可能發生乳酸酸中毒，有時是致命的。The changing tendencies of the relative contents of phosphorous contained substances have been detected by in - vivo " p magnetic resonance spectroscopy ( in - vivo " p mrs ) during the whole hatching process. in - vivo ] p mrs proved the catabolism of adenosine 5 ' - triphosphate ( atp ), phosphorous ester and phosphocreatine ( pcr ) when the embryo dead. the results could be used to deduce the conversion of phosphorous contained metabolites during the chicken embryo developed
用活體核磁共振定域氫譜（ in - vivohmagneticresonancespectroscopy ， in - vivohmrs ）對胚胎發育過程中羊水和蛋白、蛋黃的成分進行了分析；用活體磷譜（ in - vivo 』 』 pmrs ）的方法分析了在整個胚胎發育過程中含磷代謝物的相對含量隨時間的變化，表明了磷脂類物質及三磷酸腺苷（ atp ） 、磷酸肌酸（ pcr ）在此過程中的變化及可能的相互轉化的趨勢，胚胎死亡后的磷譜也證明了磷脂類物質及三磷酸腺苷（ atp ） 、磷酸肌酸（ pcr ）在死亡過程中降解為無機磷的現象。All kind of oligonucleotides ( 16 sense primers, 8 antisenset primers, 128 different primer combinations in all ) were designed from the conserved motifs glpl and cfly ( distance between them is approximately 210bp ) which existed only in the type of nbs - lrr resistance gene and used as primers for scanning the genomic dna. no specific products ( which is approximately 210bp in length and obtained from genomic dna containing ht gene ) was obtained though amplified products of approximately 500 - looobp appeared in six different primer combinations
依據nbs - lrr類r基因特有的兩個保守序列glpl和cfly （兩者相距約70個氨基酸）合成所有可能的簡並寡核苷酸引物（左引物16個，右引物8個，共組成128個引物組合）對玉米基因組dna進行擴增的結果表明：在6個引物組合中得到了擴增產物，產物長度在500 1000bp之間；沒有獲得特異性擴增產物（指僅從含ht基因材料中得到，長度約210bp的dna片斷） 。The 12940 bp nucleotide sequence of the mitochondrial genome of a brachyura dacapod, eriocheir japonica sinesis, was determined
測定了短尾類十足目動物中華絨螯蟹的線粒體基因組12940bp的核苷酸序列。Research interests : organic synthesis, including synthetic methodology, divergent oriented organic synthesis, asymmetric synthesis, asymmetric synthesis of small molecules with biological significance ( alkaloids, amino acids, pheromones, nucleosides analogues, enzyme inhibitors, receptor agonists and antagonists, bioactive heterocycles etc ) and chiral drugs
研究興趣：主要從事有機合成化學及相關的化學生物學研究，包括合成方法學、多樣性導向有機合成、不對稱合成、有機小分子調節劑（生物堿，氨基酸，昆蟲信息素，酶抑制劑，受體拮抗劑，核苷類似物等）和手性藥物的不對稱合成。Prognosis of chronic hepatitis b has been improved significantly because of the clinical application of nucleoside / nucleotide analogues, such as lamivudine, adefovir dipivoxil, entecavir
拉米夫定、阿德福韋酯和恩替卡韋等核苷/核苷酸類似物的臨床應用，大大改善了慢性乙型肝炎的預后。Pharmacogenomics combines traditional pharmaceutical sciences such as biochemistry with annotated knowledge of genes, proteins, and single nucleotide polymorphisms
藥物基因組學結合了傳統藥學理論（如生物化學）和已經定義了的基因、蛋白質和單核苷酸多態性等各類學科的研究成果。The mechanism is that the introduced complementary oligonucleotides can bind to the corresponding mrna or double - stranded dna in genome and form partial double - stranded molecules or triple - stranded nucleic acid molecules by sequence - specific and nonsequence - specific antisense action, thus the target gene will be orientationally blocked and expression of the target inhibited so that therapeutic effect could be attained. in this study, we designed a fragment of human c ii ta cdna in antisense orientation using mrna of c ii ta as template. the primers were designed based on 94 - 500 nucleotides segment in 5 " end of ciita gene so that the interested gene contained 407 base pairs which included two aug codons in 1 16 and 188 nucleotides as well as the splicing site between the first and the second exons
本研究設計以c tamrna為模板的反義cdna片段，從c ta基因5 』端第94位到500位核苷酸段設計引物，目的片段407bp ，覆蓋第116和188位兩個aug密碼子，也包含了第一外顯子和第二外顯子間的剪接位點：用常規分子生物學方法構建了反義片段的腺病毒表達載體（ padeasy - 1系統） ；腺病毒載體經hek293細胞包裝產生含反義片段的重組腺病毒，用氯化銫密度梯度離心法獲得純化的高滴度腺病毒；進行體外基因轉移，分別用反義片段真核表達載體轉染p388d1細胞和用重組腺病毒感染hela細胞，觀察導入的c ta基因反義rna抑制細胞內組成型或誘導型c ta基因表達的作用，從而達到調控mhc -類分子表達的目的。分享友人