激酶抑制蛋白 的英文怎麼說
中文拼音 [jīyìzhìdànbái]
激酶抑制蛋白
英文
rkip- 激 : Ⅰ動詞1 (水因受到阻礙或震蕩而向上涌) swash; surge; dash 2 (冷水突然刺激身體使得病) fall ill fr...
- 酶 : 名詞[生物化學] (生物體的細胞產生的有機膠狀物質) enzyme; ferment
- 抑 : Ⅰ動詞(向下按; 壓制) restrain; repress; curb Ⅱ連詞[書面語]1 (表示抉擇) or 2 (表示轉折) but3 ...
- 制 : Ⅰ動詞1 (製造) make; manufacture 2 (擬訂; 規定) draw up; establish 3 (用強力約束; 限定; 管束...
- 蛋 : 名詞1. (鳥類或龜、蛇類所產的卵) egg 2. (像蛋形的東西) an egg-shaped thing 3. (辱罵之詞)
- 白 : Ⅰ形容詞1 (似雪的顏色) white 2 (清楚; 明白; 弄明白) clear 3 (空的; 沒加他物的) pure; clear; ...
- 抑制 : 1 (控制) restrain; control; check; hold up; curb; stop; repress; bridle; choke; prehension; sup...
- 蛋白 : 1. (卵中透明的膠狀物質) egg white; albumen; gary2. [生物化學] (蛋白質) protein
-
As the cyclin dependent kinase, cdc2 may act at multiple levels during mitosis to repress ribosome biogenesis, which lead the biosynthesis to a relative silent phase, when the most of cell ' s energy expenditure is used in chromosome condensation, breakdown of the nuclear envelope, and formation of the mitotic spindle
作為cyclin依賴激酶, cdc2的激酶活性在很大程度上抑制了細胞的合成代謝,使細胞的蛋白合成進入了一個相對的靜止期,而細胞主要的能量則被應用於細胞分裂時的染色體的濃縮、核膜的降解、紡錘體的形成等。Protein kinase a is camp - dependent kinase, one of the most important signal transduction pathways, plays a pivotal role in growth, differentiation, tumor occur, cell cycle control, etc. pka activators such as camp, 8 - br - camp or phosphodiesterase ( pde ) inhibitor isomethyl butyl xanthine ( imbx ) or purified pka catalytic subunit all can inhibit germinal vesicle breakdown ( gvbd ) and meiotic maturation in mouse oocytes, also in xenopus oocytes
蛋白激酶a ( proteinkinasea , pka )是依賴于camp的絲蘇氨酸蛋白激酶,是重要的信號傳導途徑之一,廣泛參與許多生命過程,包括生長、分化、腫瘤發生、細胞凋亡、細胞周期調控等。以小鼠卵母細胞為實驗對象,給予pka激動劑camp 、 8 - br - camp或磷酸二酯酶抑制劑imbx ( isomethylbutylxanthine )均可抑制小鼠卵母細胞的胚泡破裂及減數分裂成熟。Notch interaction with its ligands induces the cleavage of its intracellular domain ( ic ), and the notch ic translocates to the nucleus and binds to rbp - j, the mammalian homolog of su ( h ), to transactivate transcription of target genes such as e ( spl ) ( enhancer of split ), hesl ( hairy and enhancer of split ) and hes5 four notch receptors and their ligands are differentially and redundantly expressed in a variety of vertebrate tissues
它通過其識別序列( cogtgggaa )結合於受調控基因的啟動子區,在轉錄激活因子的驅動下調節細胞分化和個體發育相關基因的表達。在沒有n 。 tch胞內段的情況下, rbpj可與包含sm盯( silencingmediatorforretlnoldandthyroidhormonereceptor )和組蛋白去乙酞化酶的轉錄輔助抑制復合物結合,當notch信號被激活時; rbpj可與n 。Anti - implantation effects of protein tyrosine kinase inhibitors
酪氨酸蛋白激酶抑制劑的抗生育效應及研究進展Molecular enzymology, including structure and function of enzymes, kinetics of enzyme action, inhibition, inactivation and activation, regulation mechanism of enzymatic activity, inhibitory mechanism ; exploitation and applications of enzyme products ; folding and unfolding of proteins ; biochrome ; anticancer polypeptide
分子酶學,包括酶的結構與功能、酶作用動力學、抑制動力學、失活動力學、激活動力學、酶活力調控機理、抑制作用機理;酶產品的開發與應用;蛋白質折疊與去折疊;生物色素;抗癌多肽Structure and function of enzymes ; kinetics of enzyme action, inhibition, inactivation and activation ; regulation mechanism of enzymatic activity ; exploitation and applications of enzymes and inhibitors ; folding and unfolding of proteins ; anticancer polypeptide ; canceration mechanism ; proteomics
酶的結構與功能、酶作用動力學、抑制動力學、失活動力學、激活動力學、酶活力調控機理、抑制作用機理;酶產品及酶抑制劑的開發應用;蛋白質折疊與去折疊;抗癌多肽;癌變機理;蛋白質組學The protein level of p21 increased lightly from 1 to3 h, then decreased at 6 - 9 h, reached maximum at 24 h after 2gy, it increased from 3 to 24 h exposed tology, and the protein level of p21 associated with cdk2 increased, which did not inhibit the cyclin e / cdk2 kinase activity, because of upregulation of cyclin e and deregulation of p27kipl after irradiation. in contrast to p21, p27kipl may be a key regulator of cyclin e / cdk2 activity in dna damage responses. hi the ubiquitin - proteasome pathway invovled in regulation of p27kiplexpression in response to ir the ubiquitin - proteasome pathway regulated selective and time - controlled elimination of p27 kipl
與p27ki 」 ,表達水平不同, pzi蛋白表達水平在zgy照射后略有增加, 6一gh略有下降,在照后24h達到最大; 10gy照后1一3h開始增加,持續到24h ,並且cycline / cdkz復合物中pzi蛋白結合增多,但cycline / cdkz激酶活性並未受到抑制,除了因ir誘導cydine蛋白表達水平增加外,另一重要的原因就是與pzi同一家族的p27kip ,蛋白表達水平下降,失去了對cycline / cdkz的抑制活性。A study on the regulating self - incompatibility of brassica oleracea l. by inhibitor or activitor of protein kinase
利用蛋白激酶抑制劑和激活劑調控甘藍自交不親和性Especially, apoptin is partially similar with ribonucleotide reductase, uridylate kinase and phosphotriesterase in the amino acid sequence. the similarity between them indicates that apoptin maybe takes part in the signal pathway of apoptosis with phosphotriesterase activity or operates on hnrna with ribonucleotide reductase or uridylate kinase activity
凋亡素與它們的長序列相似性表明,它可能具有磷脂酶活性,在細胞信號通路中起作用;或者具有核糖核苦酸還原酶和尿苦酸激酶活性而對hnrna發揮作用;或者是與其中具有某種活性的蛋白質存在競爭性抑制作用。Mitogen - activated protein ( map ) kinase signal transduction cascades are routes through which eukaryotic cells deliver extracellular messages to the cytosol and nucleus, and the increasing evidences showed that mapks are involved in aba -, sa - or h2o2 - signaling respectively. in addition, plant guard cells have been a well - developed model system for understanding how components interact within a signaling network in a single cell
本實驗在表皮生物分析的基礎上,主要利用顯微注射技術、膜片鉗技術和激光共聚焦顯微技術,運用專一性蛋白激酶抑制劑處理,探索蛋白激酶對蠶豆( viciafabal . )氣孔保衛細胞中aba和sa誘導的h _ 2o _ 2產生及其信號轉導影響機理,結果如下: 1Raf kinase inhibitor protein, rkip
激酶抑制蛋白They are positive regulating proteins and play a very important role in the development of neoplasma. cki are negative regulators taking part in cell cycle, which can directly or indirectly combine with the corresponding cdks to inhibit their activity. cyclin - cdk - cki constitutes a complex network regulating cell cycle
細胞周期蛋白依賴性激酶抑制因子( cyclindependentkinaseinhibitors , cki )可直接抑制相應的cdk活性或通過與cyclin競爭性結合cdk而起到抑制cyclin - cdk復合物的活性,從而作為負性調節因子參與細胞周期調控。Introduction protein kinase c ( pkc ) is a number of serine / threonine kinase family which play central regulatory roles in a multitude of cellular processes, including cell proliferation, cell cycle progression, differentiation, apoptosis. increasing evidence from studies using in vitro and in vivo systems suggests that pkc is a key regulator of critical cell cycle transitions, including cell cycle entry and exit and the gl and g2 checkpoint
前言細胞周期是細胞增殖、分化的一個重要過程,它的啟動與進程受到嚴格調控,參與調控的因子不僅包含起正調控作用的細胞周期素( cyclins ) 、細胞周期蛋白依賴性激酶( cyclin - dependentkinase , cdk ) 、還有起負調控作用的cdk抑制因子( cyclin - dependentkinaseinhibitor , cki ) 。Protective effect of p38 mitogen activated protein kinase inhibitor on organs in sepsis in rats
38絲裂原活化蛋白激酶抑制劑對膿毒癥大鼠多器官損傷的保護作用研究Staurosporine and cheleythrine, two inhibitors of protein kinase, inhibited the stimulation of meja on pm h + - atpase activity completely. 2 ) both protein kinase inhibitors and phosphatase inhibitors showed the same effect on fc - induced increases of enzyme activities
二)崗田酸和斑鰲素對fc刺激酶活力的作用有增強,增幅分別為60和50 ;蛋白激酶抑制劑星形抱菌素和白屈菜紅堿則可完全抑制fc對酶的刺激作用。3 ) the results from y - 32p tracing experiments showed that the level of isotop labeling on pm h + - atpase increased after treatment with meja and fc, respectively. okadaic acid and canthari
3 )用產p叭h標記質膜h 」 ejpase的實驗表明,同位素標記結果與蛋白激酶和蛋白磷酸酶抑制劑的實驗結果趨勢基本一致。Bbic inhibits proteases, enzymes that play important roles in the inflammation and demyelination processes that are at the heart of ms
蛋白激酶在炎癥反應和脫髓鞘反應(多發性硬化的核心變化)中起重要作用,而bbic可以抑制蛋白激酶的作用。Effects of ubiquitin proteasome inhibitor induced endoplasmic reticulum stress and apoptosis on dopaminergic neuron
泛素蛋白酶體抑制劑誘發多巴胺能神經元內質網應激反應及其凋亡的作用Progression of the cell cycle depended on the activity of a series of protein complexes composed of cyclins and cyclin - dependent kinases ( cdks ). the activity of cyclin - cdk complexes was regulated by a group of cdk inhibitors ( ckis )
細胞周期進程決定於稱之為調節亞基的周期素( cyclins )和稱之為催化亞基的周期素依賴的蛋白激酶( cdks )的結合與相互作用,同時也受到細胞周期的負調控因子? cdks的抑制因子cdis家族成員的調控。Rt - pcr kit was from takara technology co. ltd. the sequence of the primer of pkb are shown below, together with all the sodn and saodn oligodeoxynucleotide were synthesized in takara technology co. ltd. pkb primers ; forward primer 5 ' cga gaa gcc gcg acc caa cac3 ' and reverse primer 5atg cac tac cgc cgg a3 "
有絲分裂前, cdcz / cy山b 、組蛋白h ;激酶的活性通過被weel和myt激酶磷酸化cdcz的1卜巧和thr14殘基而抑制。在有絲分裂期mpf可以被cdc25活化,這兩個位點被去磷酸化, cdc25是蛋白水解酶,可以使cdcz的t打巧脫離磷酸化。分享友人