突變瘤 的英文怎麼說
中文拼音 [tūbiànliú]
突變瘤
英文
anlage tumor-
However, citrinin, produced in the growth process of monascus, is a mycotoxin and will induce teratogenicity, carcinogenicity and mutagencity
桔黴素是一種真菌毒素,作用的靶器官是腎臟,可以致畸、誘發腫瘤、突變等。Growth and nodulation competitiveness of poly - 3 - hydroxybutyrate metabolism mutants of sinorhizobium meliloti and the effects of exogenous biotin
苜蓿根瘤菌聚羥丁酸代謝突變體的競爭生長和結瘤能力以及外源生物素的影響We conclude that the gene we studied is a new loci required for efficient nitrogen fixation and for competitive nodulation of soybeans by bradyrhizobium japonicum strain gx201
我們認為在突變體菌株gx217中tn5gusa5所插入的開放閱讀框架是一個新的與競爭結瘤有關的基因。Compared to 042bm, the noea deletion mutant 042bma - km showed different degree of increase in nodule number, weight of nodule nodule and plant top dry weight on cultivars of putong zihua, baoding, ningxia, baifa and aohan, but decrease on milu. however, this mutant has no significant change in ability to nodulate cultivars of huanghou and zahua. hence, noea is involved in cultivar - specific nodulation
與苜蓿中華根瘤菌042bm相比,敲除noea的突變株042bma - km在普通紫花、保定、寧夏、百發和傲漢苜蓿品種上的結瘤數、根瘤鮮重和植株地上部分的干重都有不同程度的增加,而在秘魯苜蓿品種上的結瘤數和植株地上部分的干重明顯下降,在皇后和美國雜花苜蓿品種上則沒有明顯的變化。Monofunctional alkylating agent n - methyl - n ' - nitro - n - nitrosoguanidine ( mnng ) is a widely spread environmental mutagen and carcinogen that targets dna and proteins to generate adducts. among the adducts, o6 - alkyl guanine is the predominant mutagenic lesion because of its mispairing properties, which can eventually lead to chromosomal aberrations, point mutations, and cell death. this lesion also appears to be involved in tumor initiation, particularly in gastric carcinogenesis
單功能烷化劑n -甲基- n -硝基- n -亞硝基胍( mnng )是一種在環境中廣泛存在的化學誘變劑和致癌劑,它能和dna及蛋白質等生物大分子形成加合物( adduct ) ,其引起的與突變有關的主要dna損傷類型是o ~ 6 -甲基鳥嘌呤,這種損傷與腫瘤尤其是胃癌的發生密切相關。The research by dr lam and his collaborators from university of california, san francisco and genetech, inc. which was published in nature, a world s leading scientific journal, identifies an activating mutation in the smoothened ( smo ) gene in sporadic bccs
的科學家合作研究,發現從散發性基底細胞瘤病例中鑒定出圓滑蛋白基因的一種活化突變,使圓滑蛋白基因變成腫瘤基因,導致基底細胞瘤的出現。Germline mutations in the brca1 or brca2 tumour - suppressor genes are strong predictors of breast and / or ovarian cancer development
在brca1或brca2腫瘤抑制基因的種系突變是乳腺癌和/或卵巢癌進展的強烈預測指標。Oncogenic mutations initiate tumorigenesis, but angiogenesis is necessary for expansion of tumor mass
癌基因突變引起腫瘤形成,而血管生成則是腫瘤擴大所必需的。Mutation can also occur in cells other than germ cells - somatic mutation ? but this is likely to be apparent only when the genetically altered cell proliferates abnormally to form a large family or clone of similar cells, e. g. when a tumour forms
突變也可發生於生殖細胞以外的細胞(體細胞突變) ,但這很可能僅表現于遺傳性改變的細胞異常增生而形成一大系或克隆的相似的細胞時,例如當一個腫瘤形成時。Plant assay was performed with the wild - type strain gx201, the mutant strain gx217 and the function recovered strain rgx217. the results indicate that the mutant strain gx217 showed a day delay in nodulation time and its abilities of nodule formation efficiency and competitive nodulation were apparently decreased compared with the parental strain gx201 respectively
通過對野生型菌株gx201 ,突變體菌株gx217及其功能互補菌株rgx217進行植株試驗,發現突變體菌株gx217在結瘤時間方面較野生型菌株gx201慢一天,其結瘤效率及競爭結瘤能力均比gx201明顯降低。These genes then were analyzed in 48 additional breast or colorectal tumors, which turned up an additional 365 mutations in 236 of the genes
然後在另外48例乳腺或結直腸腫瘤中分析這些基因,在236個基因中又出現了365處突變。In the first large - scale screen of genetic changes in cancer cells, researchers have found that a typical breast or colorectal tumor results from mutations in about 90 genes, with different sets of mutations producing the same type of cancer
在首次癌細胞遺傳改變的大規模篩選中,研究者發現典型乳腺或者結直腸腫瘤源於約90種基因突變,不同的突變組合產生同種類型的癌癥。Although some diseases occur when both copies of a gene are mutated, mutation of just one copy of certain tumour - suppressor genes promotes tumorigenesis
雖然,一些疾病發生在當一個基因的兩個副本均發生突變或者只是某個腫瘤抑制基因的一個副本發生的突變促進了腫瘤的發生發展。Neoplasia, or uncontrolled cellular proliferation, can result either from mutations that " turn on " the oncogenes that stimulate growth, or from mutations that result in loss of tumor suppressor genes and their products that inhibit growth
腫瘤或失去控制的細胞增生是由於突變使癌基因啟動從而促使增生,或者由於腫瘤抑制基因和腫瘤抑制基因產物的缺失。For example, as a direct toxic effect, periodontal iruses and bacteria and their products ( endotoxins or enzymes, for example ) are toxic to surrounding cells and may directly induce mutations in tumor suppressor genes and proto - oncogenes or alter signaling pathways that affect cell proliferation or surial of epithelial cells
例如,作為直接毒性作用,牙周病毒和細菌及在細胞周圍其產生的毒性物質(例如,類毒素或酶類)可直接誘導腫瘤抑制基因和原癌基因突變或者改變細胞信號傳導通路從而影響上皮細胞增殖或存活。For example, as a direct toxic effect, periodontal viruses and bacteria and their products ( endotoxins or enzymes, for example ) are toxic to surrounding cells and may directly induce mutations in tumor suppressor genes and proto - oncogenes or alter signaling pathways that affect cell proliferation or survival of epithelial cells
例如,作為直接毒性作用,牙周病毒和細菌及在細胞周圍其產生的毒性物質(例如,類毒素或酶類)可直接誘導腫瘤抑制基因和原癌基因突變或者改變細胞信號傳導通路從而影響上皮細胞增殖或存活。Pgxn217 was transferred into bradyrhizobium japonicum strain gx201 by triparental mating using the helper plasmid prk2073. marker exchange was achieved by selection on yma containing sm, km, gm, spc et al four kinds of antibiotics. mutants were confirmed by southern blotting and hybridization with the wild - type region and the tn5 fragment respectively
隨后,利用突變質粒pgxn217誘變慢生型大豆根瘤菌菌株gx201 ,獲得了gx201的突變體菌株gx217 ;將pgxn201的3 . 4kbecori片段與plarf3連接獲得亞克隆pgxn201cl ,然後將pgxn201cl導入突變體菌株gx217 ,構建了gx217的功能互補菌株rgx217 。The comparative analysis of sequences indicated that the sequences of meq in different pathotypes are relatively conserved and the homology of the amino acid sequences is very high. the significant differences include two mutations in both mdv - 1 vaccine strains cvi988 / rispens and 814 strain : the deletion of a proline ( no. l93aa ), and this mutation is just exactly located in a 15 - amino - acid ( eelcaqlcstppppi ) repeat sequence within the c - terminal transactivation domain of meq protein ; and a point mutation with a shift from alanine ( a ) of all virulent strains to serine ( s ) was occurred on the no. 71 aa
結果發現, mdv不同致病型的meq基因序列相對比較保守,它們相互間核苷酸和氨基酸序列的同源性均很高;但是,與所有七個致瘤性的mdv毒株相比,二個型弱毒疫苗cv1988 rispens株和814株均出現了兩個特徵性的突變:即第194位的p缺失性突變和第71位氨基酸由a變成了s的位點突變;缺失性突變恰恰位於meq基因中轉錄激活域內的一個多脯氨酸的重復序列( pppp )之中。Conversely, the tumors might mutate to “ escape ” the immune onslaught engendered by a dendritic cell vaccine
反之,腫瘤可能也會產生突變,因而躲過樹突細胞疫苗引發的免疫攻擊。Transformed, oncogenic precursors, possessing both defining neural - stem - cell properties and the ability to initiate intracerebral tumours, have been identified in human brain cancers
人類腦部腫瘤中已經證實,突變的致瘤前體細胞不僅具有神經幹細胞性能並且能致腦部腫瘤發生的潛能。分享友人