腫瘤促進作用 的英文怎麼說
中文拼音 [zhǒngliúcùjìnzuòyòng]
腫瘤促進作用
英文
tumor enhancement-
[ conclusion ] taken together, these data suggested that two peptides gwyydal and vasavfysalve were effective mimickers of vegf and these peptides maybe potent inhibitors of kdr and offer a hope for the construction of tumor vaccine
而且該模擬抗原表位可能與huvec上表達的vegf受體結合,從而抑制了vegf的促huvec生長作用。這為進一步定位vegf抗原表位,研究vegf受體結合抑制肽,設計腫瘤疫苗提供了有力的基礎。To investigate the mechanism of trefoil factor 3 on the gastric intestine epithelial restitution, the recombinant human trefoil factor 3 was added to human colonic tumor cell and the proliferation effect was examined by mtt assay. the recombinant protein didn t promote the proliferation of the hct cells at low density of 0. 010. 05 g l and only has weakly proliferation effect at density of 0. 10. 2 g l. 1 g l of the recombinant protein could significantly promote the cell migration of hct cells when added to the monolayers cells
將重組人三葉因子3 trefoil factor 3 , tff3作用於人結腸腫瘤細胞,研究重組蛋白對細胞增殖的影響,結果發現該蛋白在較低的濃度1050 mg l下對細胞的增殖基本沒有影響,在100200 mg l濃度下該蛋白對細胞僅有微弱的刺激作用,提高濃度對細胞增殖作用沒有改變。同時研究了tff3對損傷的單層結腸腫瘤細胞遷移的影響,發現tff3對細胞有明顯的促進遷移作用。The characteristics of this method are : a, directly counting cell number without the influence of the metabolic state of the cells ; b, discrimination of target cells from effector cells in cell - mediated cytotoxicity assay ; c, less treatment step, and free - radioactivity ; d, high sensitivity and reliability. 2, using the above assay, immunofluorescent labeled technique, and flow cytometry, the pbmc proliferation, apoptosis, necrosis, cell cycle, activation, cytokines and membrane marker were detected. the results showed that the number of pbmc reduced, but the activity of pbmc increased dose - dependently ; the reduction of cell number resulted from necrosis and apoptosis ; the supernatant of k562 cell lines were not able to block the cell cycle, but to promote it ; the ratio of t cell subset and the expression of thl and th2 cytokines increased
結合以上創建的方法和免疫熒光流式細胞術,用k562細胞株可溶性分泌物(上清)對外周血單個核細胞( pbmc )進行培養以模擬體內微環境,然後分別從細胞增殖、凋亡、壞死、細胞周期、活性、細胞因子和表面抗原表達等方面進行研究,結果發現用腫瘤上清培養的pbmc細胞數量下降明顯,但同時對其有激活作用,且呈劑量依賴性;細胞數的下降主要是由細胞壞死和凋亡引起的,腫瘤上清對細胞周期沒有阻斷作用,反而略有促進作用; t細胞亞群比例增加,並促進表達th1 、 th2細胞因子。At present, in an attempt to stimulate specific antitumor immunity, experimental models and clinical studies are currently evaluating the potent antigen - presenting capacity of dc combined with single or multiple tumor antigen epitopes. however, there are several problems in utilizing pulsing dc with synthetic immunodominant peptides from identified antigens. 1 ) the potential induction of tolerance ; 2 ) the need to determine the patient ' s hla haplotype, the limitation of therapy to patients whose tumors express defined specific tumor antigens in the context of the correct hla phenotype, the unavailability of peptides for all hla haplotypes ; 3 ) the lack of cd4 help cell - related epitopes for most antigens ; and 4 ) the ctl resulting from such protocols have a good in vitro capacity to kill peptide - pulsed target cells but only a modest capacity to kill tumor cells
但是,學者們發現這一療法存在著如下的缺陷:單一ctl表位抗原肽的應用其抗腫瘤作用弱於多種腫瘤抗原的聯合應用,且有誘導免疫耐受的潛在危險,有時反而會促進腫瘤的生長;事先需對患者的hla單倍型進行鑒定,以確定ctl表位與hla單倍型是否匹配,目前尚缺乏能與所有hla單倍型相匹配的ctl表位,從而限制了這一療法的應用;這一療法所產生的ctl在體外能有效殺傷經腫瘤抗原肽共孵育過的靶細胞,但對腫瘤細胞的殺傷能力較弱:這種l表位抗原肽缺乏cd4汀h細胞相關的表位,因此,不能誘導有效的th細胞免疫應答。Without the formation of new blood vessels, tumors cannot expand beyond a few cubic millimeters, and that the rate of tumor growth correlates with the formation of new blood vessels. neovascularization may also be a critical role of tumor metastasis since it enhances entry of tumor cells into the circulation. consequently, highly vascular tumors may have the potential to produce metastases at a higher rate than less angiogenic tumors
沒有新生血管形成,腫瘤生長超不過幾個立方毫米,並且腫瘤生長速度與血管新生程度有關。新生血管在腫瘤轉移中也有重要作用,促進腫瘤細胞進入血液循環,血管生長豐富的腫瘤比缺乏血管生長的腫瘤更容易發生轉移。因此抑制腫瘤組織的新生血管形成,從而抑制腫瘤生長和發生轉移已成為腫瘤治療的一個重要策略。3, the effect of k562 cell lines supernatant on no production by pbmc was investigated using the specific immunofluorescence probe daf - 2da. the results showed that the k562 cell lines supernatant could promote the no production by pbmc. further study found all the activated pbmc ( cd69 + ) produced no, while not all the no positive pbmc were activated
利用daf - 2da作為細胞內no特異性的熒光探針,研究了k562上清對pbmc產生no的影響,國內未見類似報導,發現腫瘤上清能促進pbmc細胞no的產生,進一步發現活化的細胞( cd69 + )均產生no ,而no陽性的細胞不一定活化的。The thymus hormone that the thymus excretes can contradict tumor, virus and bacteria, it can also improve the body ' s cell immunity, non - special immunity and combating infection ability through promoting cell ' s function and quantity
胸腺分泌的胸腺素具有抗腫瘤、抗病毒、抗細菌等作用,還能通過促進細胞的功能和數量的恢復,從而提高機體的細胞免疫和非特異型免疫,增強機體的抗感染能力。In this paper, we mainly discuss the research progress of staphylococcal enterotoxin a in the aspects of the biological activities and its effect on promoting lymphocyte proliferation and inhibiting tumor cell growth
摘要該文就葡萄球菌腸毒素a的生物學活性、促淋巴細胞增殖和抑制腫瘤細胞生長作用的研究進展作一綜述。Recombinant il - 2 is used as a clinical immune preparation to several kinds of tumors. it can affiliate the basal secretion of acth, prl, tsh in tissue pieces of pituitary, having a function on the secretion of lh, fsh, gh simultaneously
臨床上用大劑量的重組il - 2對腫瘤進行免疫治療, il - 2可第四軍醫大學碩士學位論文以促進垂體組織塊acth 、 pgy和tsh的基礎分泌,對lh 、 fsh和gh的分泌也有作用。When the body suffered from malignancy, on the one hand, tumor restrained cell immunity function, antibody ' s production and the body ' s immunity effect through inducing restraining t cell, so it accelerated tumor ' s growth, on the other hand, tumor induced body fluid restrained gene, which prevented t cell and nk cell from killing tumor and restrained lymphocyte to mitotic multiplication reaction, indeed it accelerated tumor ' s growth
當機體一旦患上惡性腫瘤后,一方面腫瘤通過誘導抑制性t細胞,抑制細胞免疫功能及抗體的產生,抑制機體對腫瘤的免疫效應,從而使腫瘤逃逸機體的免疫監視,促進腫瘤的生長。另一方面,腫瘤通過誘導體液抑制因子阻止t細胞和nk細胞的等對腫瘤的殺傷作用,抑制淋巴細胞對有絲分裂原的增殖反應,甚至促進腫瘤的生長。Cancer researchers have long worked to understand why some prostate cancers recur after the use of therapies designed to stop the production of testosterone and other androgens that fuel cancer cell growth
癌癥研究者長期以來致力於研究為什麼有些前列腺癌在採取了阻斷具有促進癌細胞生長作用的睪酮以及其他雄激素的產生后仍然會有腫瘤復發。It was proved that the protein was got by sds - page. the successful cloning and expressing of vp3 gene become the basis for the study and exploiture of apoptin
目前,對凋亡素的研究主要集中在其促進腫瘤和轉化細胞選擇性凋亡的功能方面,而對其作用機理和空間結構方面的報道較少。分享友人