致癌性轉化 的英文怎麼說
中文拼音 [zhìáixìngzhuǎnhuà]
致癌性轉化
英文
oncogenic transformation-
In our laboratory, a unique mutation detection system using a shuttle vector plasmid has been established to demonstrate that a low concentration of mnng ( 0. 2 m ) can induce nontargeted mutation in mammalian cells : the mammalian cells were exposed to 0. 2m mnng for 2. 5h, then a shuttle plasmid pz189 carrying supf trna gene was transfected into cells after 24h culture. we found a 5 - fold higher mutation frequency of the plasmid replicated in pretreated cells than the spontaneous mutation frequency of the plasmid replicated in control cells. this kind of mutation did not occur immediately after mnng exposure
我們實驗室曾用一特殊的突變檢測系統，直接證明dna損傷劑可在哺乳動物細胞誘發非定標性突變：首先用低濃度（ 0 . 2 m ）的短壽烷化劑mnng （半壽期為1 . 1hr ）處理細胞2 . 5h后，繼續培養24h ，將重組有用作突變檢測的靶基因supftrna基因的穿梭質粒pz189轉入細胞復制，發現在未受致癌物直接攻擊的穿梭質粒中有較自發突變率高5倍以上的靶基因突變。Think now, undesirable disposition sends cancer to adopt 3 approaches : it is to promote cancer cell to grow ; the 2 immune force that are scathing airframe ; the 3 active that are enzymatic department of change airframe small system, affect the change of other and chemical carcinogen
現認為，不良性格致癌通過三條途徑：一是促進癌細胞生長；二是損傷機體的免疫力；三是改變機體微體酶系的活性，影響其他化學致癌物質的轉變。
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