芳香化酶 的英文怎麼說
中文拼音 [fāngxiānghuà]
芳香化酶
英文
aromatizing enzyme-
Estrogens are synthesized from androgens through the activity of aromatase
雌激素通過芳香化酶作用由激素合成而來。Estrogen ( e2 ) is one of the steroid hormones, which is mainly synthesized and secreted by the gonad affecting proliferation, differentiation and function exerting of target tissues. circumferential estrogens were mainly produced by ovary and spermary, and the brain estrogens came mostly from hypothalamus, neurons of limbic system and neuroglias
雌激素四)是由芳香化酶催化雄激素轉化而來的,它影響靶組織的生長分化和功能發揮,外周雌激素主要由卵巢、睪丸產生,腦內主要由下丘腦、邊緣系統的神經元和神經膠質細胞產生。That shows there are some difference in the steroid regulation between the anuras and the urodeles. among three of the steroid, one can convert to the other, and some enzyme activity is concerned with the conversion
三種類固醇激素存在相互轉化的關系,睪酮可能在雌二醇和孕酮的轉化中起著底物的作用,這種轉化與某種芳香化酶的活性有關。When drugs administration on the baby fish stopped, the effect on behavior and morphology disappeared. aromatase is the key enzyme for estrogen synthesis
芳香化酶是雌激素生物合成中的關鍵酶,它俗化從雄激素合成雌激素的反應。Objective to determine the investigation progression on exemestane in the treatment of breast cancer
摘要目的探討新一代抗芳香化酶藥物依西美坦用於乳腺癌臨床治療的研究進展。Results exemestane is an effective steroidal aromatase inactivator with superior tolerability, safety and efficacy in the adjuvant, neo - adjuvant and metastatic therapy of breast cancer
結果依西美坦是口服有效的芳香化酶滅活劑,其耐受性好、安全性高,在乳腺癌的輔助治療、新輔助治療及轉移性乳腺癌的治療中均取得較好療效。When both genes were co - expressed in e. coli, the activity of ppsa varied from 2. 1 - 9. 1 fold comparing to control, but the activity of tkta was relatively stable ( 3. 9 - 4. 5 fold ). whatever the two genes were expressed respectively or cooperatively, both could promote the production of dahp, the first intermediate of the common aromatic pathway, but co - expression was more effective on forming dahp and screened ppt - and ptp - as more effective. the results demonstrate that co - expression of ppsa and tkta can improve the production of dahp, and what ' s more, when multigenes co - expressed, the recombinant which has coordinated enzymes activity is optimum
莽草酸途徑的最優化和整體調控基因csra的敲除正是上述改變的分子基礎,同時也為三種芳香族氨基酸的基因工程菌的構建打下了基礎; 7 .在國內外首次實現了共同途徑限制性底物關鍵酶ppsa刁無『及arog與分支途徑關鍵酶基因phea的串聯高效表達,所構建的重組質粒ptga ,其ppsa 、 tkta 、 arog 、 cm和pd的酶活分別比對照提高了3 、 2 、 2 , 5 、 4 、 2 . 3倍,且其酶活比較協調一致; 8 .將ptga導入到篩選的基因敲除和基因替換菌株大腸桿菌31884 c甲b中,搖瓶發酵證實比以往所構建的基因工程菌株具有較高的phe產量和糖轉化率率,分別為0 . 448 %和22 . 4 % 。While the aromatase brain type in brain tissue was not affected
在腦中,腦型芳香化酶表達未受到影響。Several large - scale clinical trials about aromatase inhibitors and medical ovarian ablation are ongoing and attract attention widely
芳香化酶抑制劑及藥物去勢等多個大型的臨床研究還正在進行並備受關注。We also found that the mrna expression of aromatase brain and ovary type in gonad tissue were much lower than control all - female group in 48dah
在48dah ,腦型芳香化酶和卵巢型芳香化酶在性腺的mrna表達量與全雌對照組相比明顯降低。Now, tamoxifen is still the standard endocrine therapeutic drug or the premenopausal patients, but aromatase inhibitors can bring more benefit for the postmenopausal patients
目前,三苯氧胺對絕經前患者仍是內分泌治療的標準用藥,但對絕經後患者應用芳香化酶抑制劑會有更大的效益。Very similar to the results of fadrozole, the expression of aromatase brain and ovary type mrna in gonad was much lower than control group, while in brain tissue aromaiase brain type was not affected
在48dah ,腦型芳香化酶和卵巢型芳香化酶在性腺的mrna表達量與全雌對照組相比明顯降低,在腦中,腦型芳香化酶表達未受到影響。Anyhow, what we unexpected was that we did not get any male fish in the higher dosage fadrozole group, which was confirmed by naked eyes observation, histological dissection and aromatase mrna expression in the corresponding tissues
意料之外的是,高劑量的fadrozole處理反而得到了全雌,肉眼、組織學、芳香化酶mrna水平檢測均如此。Besides fitting the own growth of gonad, the main function of the increase of mitochondria is to provide energy to the synthesis of estrogens, the main function of smooth endoplasmic reticulum is for the synthesis of the steroid hormone
在卵巢分化中線粒體和光面內質網增多,除了適應性腺本身的發育生長外,線粒體的增多主要是為芳香化酶把雄性激素轉化為雌激素的作用提供能量,光面內質網的增多是有利於類固醇激素的合成。It presented a natural target because aromatase converts testosterone into estradiol, a potent form of estrogen also used in hormone replacement therapy
由於芳香酶能把睪酮轉化為雌二醇,而雌二醇也是一種能用於激素替代療法的雌激素,它就提供了一個天然的靶點。分享友人