轉導因子 的英文怎麼說
中文拼音 [zhuǎndǎoyīnzi]
轉導因子
英文
tra duced element-
Comprehensive cellular responses was found in human amnion fl cells following exposure to low concentration of mnng, such as the lowering of dna replication fidelity resulted from alteration of dna polymerase profile ; activation of a lot of transcription factors, such as api, creb, nf - kb etc ; clustering of egfr ( epidermal growth factor receptor ) and tnfr ( tumor necrosis factor receptor ) and activation of camp - pka - creb and jnk / sapk signal pathways
我們發現，低劑量mnng處理后的人羊膜fl細胞有廣泛的細胞反應，並有多個信號轉導通路的激活和基因表達的改變。例如dna復制保真度下降， dna聚合酶譜發生改變，應用報告基因技術和底物磷酸化檢出技術證明細胞一系列轉錄因子如ap1 、 creb 、 nf b等被激活，細胞表面受體如表皮生長因子受體、腫瘤壞死因子受體發生聚簇，細胞信號轉導通路camp - pka - creb和jnk sapk被激活。The b lymphocyte stim lator ( blys ) also known as baff, tall - 1, thank, ztnf4, is the most recent addition to the tumor necrosis factor family ( tnf ) ligands. blys induces both in vivo and in vitro b cell proliferation, differentiation and immunoglob lin secretion. meanwhile, it also strongly suppresses the growth of tumor cell lines. the over - production of blys is associated with the development of certain autoimmune disease, such as systemic lupus erythaematosus ( sle ), rheumatoid arthritis, myasthenia gravis, sj greh ' s syndrome
人b淋巴細胞刺激因子（ hblys ）是1999年發現的腫瘤壞死因子超家族成員。最早發現其可誘導腫瘤細胞凋亡，之後發現它是一個強有力的b細胞共刺激因子，它在體外及轉基因動物體內可明顯刺激b細胞的生長，免疫球蛋白分泌，並導致動物自身免疫性改變。But without rdrp transcription were tested. so it is suggested that tm - 22 is a relative to multi - protein transcriptional coactivator. mip204 and pr - la gene expression can be induced in resistant response and do not relate to rdrp gene transcription
因此，可以認為tm一22基因的編碼蛋白與復合蛋白轉錄因子有關，在抗病反應中能夠誘導五刃滬204和屍尺一ia基因的表達，與rdrp基因的轉錄沒有直接的聯系。For example, we have found the clustering of egfr ( epidermic growth factor receptor ) and tnfr ( tumor necrosis factor receptor ) and the activation of camp - pka - creb and jnk / sapk pathways after mnng treatment
例如細胞表面受體如表皮生長因子受體、腫瘤壞死因子受體發生聚簇，細胞信號轉導通路camp kacgyb和jnk sapk被激活。The tumor cells transfected with restin are arrested in gl phase and the cell proliferation is inhibited. it implies that restin may be correlated to cell cycle regulation. other data showed that the necdin, a homolog of restin, could suppress cell growth by interacting with transcription factor e2f1 and p53
而與restin的同源蛋白的necdin ，可以與細胞周期促進蛋白sv40大t抗原、腺病毒eia 、轉錄因子ezfi等相互作用，抑制細胞生長;也可以和轉錄因子p53作用參與生長抑制和抑制p53誘導的細胞凋亡。This experiment passing to grope for the carbon source constitutes of the culture medium and using t. reesei rut c - 30 induced the expression of # - mannanase ( # - 1, 4 - mannan mannohydrolase ec 3. 2. 1. 78 ). in this experiment i put the constant carbon source ( lactose and locust bean gum ) in the foundation culture medium ( mandels nourishment liquid ) of t. reesei rut c - 30, then proceeded the variable carbon source ( dragon spruce fiber, com rush pith fiber, wheat straw fiber, wheat straw xylan, corn rush pith xylan, dragon spruce mannan ) to single factor, double factor, three factor, four factor and five factor orthogonal experiment. 1 determined the activity of p - mannanase using locost bean gum as substract by the 3, 5 - dinitosalicylic acid method, and observed the growing situation of the gernic at the end i selected the directions for the inducement expression of the # ? mannanase from trichoderma reesei rut - c30 that contained the dragon spruce fiber, wheat straw xylan, dragon spruce mannan
在里氏木霉rutc - 30的基礎培養基（ mandels營養液）中加入固定碳源乳糖和槐豆膠，然後將可變碳源（雲杉纖維、玉米芯纖維、麥桿纖維、麥桿木聚糖、玉米芯木聚糖、雲杉甘露聚糖）進行單因子、雙因子、三因子、四因子、五因子的里氏木霉rutc - 30正交培養實驗，並以槐豆膠為底物用3 ， 5二硝基水楊酸法測定培養液中?甘露聚糖酶的活力。從而確定了酶活最高且菌體生長良好的含雲杉纖維、麥桿木聚糖和雲杉甘露聚糖的誘導培養基為最佳培養基，用該培養基培養的里氏木霉（ t . reesei ） rutc - 30使其轉錄的-甘露聚糖酶（ - 1 ， 4 - mannanmannohydrolaseec3 . 2 . 1 . 78 ） mrna量能夠滿足rt - pcr的要求。Curcumin has been shown to induce a wide variety of tumor cells by several mechanisms, mainly including modulation of the expression of oncogenes and cancer suppressor genes, down - regulation the activation of transcription factors, via many signal transduction pathways, and the modulation of cell cycle. provides an overview of domestic and international apoptosis mechanisms of malign tumor cells induced by curcumin in order to better explore and open up new avenues of cancer treatment
姜黃素能夠誘導多種腫瘤細胞系凋亡，其機制主要是調控癌基因和抑癌基因，下調多個轉錄因子活性，通過多種信號轉導途徑，誘發細胞周期停滯而誘導細胞凋亡.對近年來姜黃素誘導細胞凋亡的機制進行綜述，以便更好地探求和開辟治療惡性腫瘤的新途徑。In order to study the expression of 3 - defensins in liver as acute phase response proteins, a murine systemic acute phase responsive model was established by intraperitoneal injection o f lipopolysaccharide ( lps ) in our study. the mbd3 cdna sequence ( 145 - 169 bp ) was labled with [ - 32p ] atp as a probe to detect mbd3 mrna in different tissues by northern blot and analyze the time - and dose - dependant expression caused by lps. the 5 " flanking sequence ( - 167 - 179 bp ) of the mbd3 gene was designed as the probe and labled with [ - 32p ] dctp to investigate the binding of transcriptional factors to this region by electrophoretic mobility shift assay ( emsa ) and south - western blot
以小鼠mbd3基因145 ? 169bpcdna序列合成探針，經[ - ~ （ 32 ） p ] atp標記后通過northernblot方法檢測mbd3在肝臟中的表達，同時分析了mbd3基因誘導表達的組織特異性，劑效和時效關系；結合mbd3基因啟動子區序列分析，以- 164 ? - 179bp雙鏈dna序列合成探針，經[ - ~ （ 32 ） p ] dctp標記后通過電泳遷移率改變實驗（ emsa ）和south ? westernblot方法對參與mbd3在肝臟中誘導表達調節的轉錄因子進行分析。The results of emsa showed the obvious retardant bands, which suggest that some proteins in nuclei can bind to the specific dna sequence of mbd3 gene after lps treatment. 5. the molecular mass of this dna binding protein was assessed between 43. 0 - 66. 2 kd by south - western blot
4 .電泳遷移率改變實驗有明顯的滯后帶形成，表明lps刺激后，肝臟組織的細胞核內有轉錄因子與mbd3基因特異的dna序列結合，參與mbd3基因的誘導表達5 . south一westemblot進一步確定此轉錄因子分子量在43 . 0一「 . 2kd之間。C - myc, as a nuclear transcription factor, can influences spermatogenesis through inducing the transcription of dna
Ewe也是作為核轉錄因子通過誘導dna的轉錄而調控精子的發育過程。One is as signal transducers outside of the nucleus, named nongenomic action. the other is as transcription activators in the nucleus, named genomic action. the two ways may coexist, cooperate and coregulate in the development and maturation of oocyte
類固醇激素受體在卵母細胞中可能通過兩種途徑發揮作用，一種是存在於胞質中，作為信號轉導因子的非基因組調控機制；另一種是存在於核中，作為核轉錄活性因於，改變基因轉錄活動的基因組調控機制。The following research areas will be involved in the project : ( 1 ) mechanism of hereditic factors and its function in chinese type 2 diabetes ; ( 2 ) metabolomics on the cell stress and its nutrition intervention in the type 2 diabetes ; ( 3 ) mechanisms of metabolic nuclear receptors in the process of insulin resistance and type 2 diabetes onset ; ( 4 ) roles of signal transduction molecules, lipid metabolic disorder to insulin resistance ; ( 5 ) type 2 diabetes development and role of pathological changes of blood vessels ; ( 6 ) abnormal insulin secretion, apoptosis and type 2 diabetes ; ( 7 ) function of molecular network of type 2 diabetes progression
本項目擬開展以下研究工作： （ 1 ）中國人2型糖尿病發生過程中遺傳因素的發現及其作用機制； （ 2 ）細胞應激在中國人2型糖尿病發生過程中的作用機制及其營養干預的代謝組學； （ 3 ）代謝性核受體在胰島素抵抗和2型糖尿病發病中的作用機制； （ 4 ）細胞信號轉導分子、脂代謝紊亂與胰島素抵抗的關系； （ 5 ） 2型糖尿病發展過程與血管病變； （ 6 ）胰島素分泌異常、細胞凋亡與2型糖尿病； （ 7 ） 2型糖尿病發生過程中的分子網路與作用機制。We detected the transcription and translation change of different thrs genes by semiquantitative reverse transcription - polymerse chain reaction ( rt - pcr ) analysisjelisa respectively. at same time the differentiated cell were identified by immunocytochemistry method. results ( l ) nsc induced by mitogens were nestin - positive and incorporated by brdu
以pdgf 、 t _ 3對nsc進行誘導分化，並分別用rt - pcr半定量法、 elisa法檢測nsc在不同誘導因子作用下分化前後thr各亞型在轉錄與翻譯水平上的表達變化，用免疫細胞化學方法鑒定分化后的細胞類型。The intracellular domain has four distinct regions : the ram domain, the ankyrin repeats, a transcriptional activator domain ( tad ) and the pest ( proline -, glutamate -, serine -, threonine - rich ) sequence. two nuclear localisation sequences are present prior to and following the ankyrin repeats
釋放的胞內區不經其它信號轉導分子的作用可直接進核，與dna結合蛋白rbp - j相互作用並激活下游基因如果蠅的e （ spl ） （ enhancerofsplit ）復合體及哺乳類的hes （ hairyandenhancerofsplit ）家族基因。Hypoxia - inducible factor ( hif ) is an oxygen - dependent transcription factor that activates a diverse set of target genes, the products of which are involved in adaptive processes to hypoxia
低氧誘導因子（ hif ）是一種氧依賴性的轉錄因子，其為低氧適應性過程中的產物，可激活各種靶基因。It is well documented that they jointly take part in gene transcription that led by rna polymerase ii. however, whether baf complex and nf1 / ctf are also involved in the formation of rna polymerase ii - mediated transcription initiation complex is still uncertain, and a number of the currently proposed models still lack the support of experimental data
哺乳動物swi snf （ baf ）復合物和轉錄因子（ nf1 ctf ）都是轉錄活動的重要調控因子，許多實驗證實，它們共同參與了基因轉錄調控活動。 baf復合物與轉錄因子nf1 ctf是否一同參加了由rna聚合酶介導的基因轉錄起始復合物的形成，目前還沒有比較一致的認識，已有的模型仍缺乏實驗支持。Therefore, the osbhlh1 gene is one novel member of the bhlh transcriptional factors family possible involved in the cold signal transduction pathway
表明osbhlh1可能是參與冷脅迫信號傳導途徑中的一個新的轉錄因子，轉基因耐逆試驗正在進行。However, the mechanism for the later is not clear yet. our preliminary experiments suggested that extracellular calmodulin might be involved in rbcs gene expression in the dark. in order to provide direct evidence that extracellular calmodulin activated rbcs transcription in a light - independent manner, we intended to get the transgenic plants carrying light - dependent and - independent rbcs promoter fused to a reporter gene
如果細胞外鈣調素確實是光不依賴型rbcs基因暗中表達的誘導因子，它對其mrna水平的影響應是通過提高其轉錄水平即調節其啟動子活性實現的，我們計劃以轉番茄rbcs3a - gusa和rbcs3c - gusa的煙草懸浮培養細胞系為試驗材料進一步證實這一點。An understanding of the complex chain of neurotransmitters, “ second messengers, ” transcription factors, genes and other miscellaneous molecules needed to make a long - term memory is leading to drugs that may ultimately help more than those beset with alzheimer ' s or more benign forms of dementias that plague the aged
了解參與長期記憶的復雜過程，包括神經傳遞物、二級傳訊分子、轉錄因子、基因與其他五花八門的分子，最後引導我們研發的新藥物，不只有助於受到阿茲海默癥或其他失智癥問題困擾的年邁患者而已。We have compared the inferred transcription factors from this previous study with additional predictions of regulatory transcription factors using two alternative promoter sequence analysis techniques
我們比較了先前研究推導出的轉錄因子和本研究採用另外兩種啟動子序列分析技術的預測結果分享友人