轉錄激活 的英文怎麼說

中文拼音 [zhuǎnlùjīhuó]
轉錄激活 英文
transcriptional activation
  • 轉 : 轉構詞成分。
  • 錄 : Ⅰ名1 （用做記載物的名稱） record; register; collection; selections 2 （姓氏） a surname Ⅱ動詞1 （...
  • 激 : Ⅰ動詞1 （水因受到阻礙或震蕩而向上涌） swash; surge; dash 2 （冷水突然刺激身體使得病） fall ill fr...
  • 活 : Ⅰ動詞1 （生存; 有生命） live 2 [書面語]（救活） save （the life of a person）:活人無算 （of a goo...
  • 轉錄 : [電學] transcribe; transfer; [聲學] mixing; rerecording; [生物學] transcription; duplicating轉錄...
  • 激活 : activation; sensitization; activate; sensitize; active激活材料 active material; 激活劑 activating...
  1. Comprehensive cellular responses was found in human amnion fl cells following exposure to low concentration of mnng, such as the lowering of dna replication fidelity resulted from alteration of dna polymerase profile ; activation of a lot of transcription factors, such as api, creb, nf - kb etc ; clustering of egfr ( epidermal growth factor receptor ) and tnfr ( tumor necrosis factor receptor ) and activation of camp - pka - creb and jnk / sapk signal pathways

    我們發現，低劑量mnng處理后的人羊膜fl細胞有廣泛的細胞反應，並有多個信號轉導通路的激活和基因表達的改變。例如dna復制保真度下降， dna聚合酶譜發生改變，應用報告基因技術和底物磷酸化檢出技術證明細胞一系列轉錄因子如ap1 、 creb 、 nf b等被激活，細胞表面受體如表皮生長因子受體、腫瘤壞死因子受體發生聚簇，細胞信號轉導通路camp - pka - creb和jnk sapk被激活。
  2. At rest, the heterodimeric rel / nf - k b complex is located in the cytoplasm bound to an inhibitory factor, i k b. upon stimulation, i k b is phosphorylated and degraded, free nf - k b then translocates into the nucleus where it binds to k b site to regulate transcription

    靜息時， re皿4bh聚體與抑制蛋白kbs結合，在細胞漿中保持無活性。受到刺激， ikb分子迅速磷酸化並降解，釋放nf兒b轉位入核，通過與kb位點結合調節轉錄。
  3. Notch interaction with its ligands induces the cleavage of its intracellular domain ( ic ), and the notch ic translocates to the nucleus and binds to rbp - j, the mammalian homolog of su ( h ), to transactivate transcription of target genes such as e ( spl ) ( enhancer of split ), hesl ( hairy and enhancer of split ) and hes5 four notch receptors and their ligands are differentially and redundantly expressed in a variety of vertebrate tissues

    它通過其識別序列（ cogtgggaa ）結合於受調控基因的啟動子區，在轉錄激活因子的驅動下調節細胞分化和個體發育相關基因的表達。在沒有n 。 tch胞內段的情況下， rbpj可與包含sm盯（ silencingmediatorforretlnoldandthyroidhormonereceptor ）和組蛋白去乙酞化酶的轉錄輔助抑制復合物結合，當notch信號被激活時； rbpj可與n 。
  4. The two single - pass transmembrane proteins, delta and serrate, have been identified as notch ligands. the transcription factor suppressor of hairless [ su ( h ) ] is the major downstream effector of notch signaling pathway. rbp - j, the mammalian homolog of su ( h ), recognizes the core sequence ( c / tgtgggaa ) of dna

    Rbp - j是果蠅促神經發生基因su （ h ） （ suppressorofhairless ）在哺乳動物的同源物，它通過其識別序列（ c tgtgggaa ）結合於受調控基因的啟動子區，在轉錄激活因子的驅動下調節細胞分化和個體發育相關基因的表達。
  5. Mint ( msx2 - interacting nuclear target protein ) can interact with rbp - j and msx2 ( the murine homologue of drosophlia muscle - segment homeobox ), and represses their transcription activation activity

    進一步的研究表明mint可以與n成ch受體的胞內段競爭結合rbp j ， n而抑制rbp刁的轉錄激活作用。
  6. Zygotic genome activation ( zga ) is a nuclear reprogramming event that transforms the genome from transcriptional quiescence at fertilization to robust transcriptional activity shortly thereafter

    合子基因組激活（ zga ）是一個細胞核重編程事件，使基因組從受精時的轉錄靜止轉變為立即的活躍轉錄。
  7. It can be concluded from the results that c - myc plays an important role in regulatin g the related genes in meiosis of spermatomeres and spermiogenesis and in regulating the secretion of the secretory cells in the spermatheca

    從實驗結果看， myc蛋白可能在減數分裂中激活相關基因，尤其是在精細胞形成早期可能參與了精細胞內大量的基因轉錄，還可能參與了受精囊囊壁上皮細胞的分泌活動。
  8. Stat3 ( signal transducer and activator of transcription 3 ) is important for embryo morphogenesis, cell growth, apoptosis and cell mobility

    信號轉導和轉錄激活因子3 （ stat3 ）在動物的早期胚胎發生、細胞生長、凋亡控制和細胞運動等過程中起著很重要的作用。
  9. Ie protein have multiple functions, such as conversion of the host cell into a metabolically activate states, activation of viral early genes in the early phase, repression of their own transcription. ie 180 proteins can stimulate transcription from both homologous such as the icp4 of hsv ( herpes simplex virus ) and heterologous viral and cellular promoter such as - globe protein

    經分析偽狂犬病病毒立即早期蛋白（ immediate - earlyprotein180 ， ie180 ）的蛋白質結構，發現ie180具有轉錄激活因子的結構特徵，能與類rna聚合酶結合， ie180基因缺失突變體對sv40及cmv啟動子調控作用的研究，是考察ie180能否作為轉錄激活因子應用的關鍵。
  10. Characterization of transcription activity and expression profile of at2g31070, a member of tcp family in arabidopsis

    31070的轉錄激活活性鑒定與表達譜分析
  11. This result show the deleted fragment is n ' t the key domain to transactivation. 2 ) the mutant p6p2 translate a peptide includiing 165 amino acid and acted as inhibition to sv40 promote

    （ 63加152 1079氨基酸段）對sv40啟動子的均有轉錄激活活性，這表明缺失的氨基酸片段（ 64 151氨基酸序列）對轉錄激活是非必需的。
  12. Analysis of transcriptional activation abilities of three gmdreb proteins in yeast indicated that gmdreba and gmdrebb could activate the expression of a reporter gene, whereas gmdrebc could not

    轉錄激活活性分析表明， gmdreba和gmdrebb蛋白能夠激活下游報告基因的表達，而gmdrebc不能，說明gmdrebc蛋白不具有轉錄激活活性。
  13. To further enhance protein productivity of expression vectors, two artificial transcription activating domains, ah and vp2, were linked to cl represser protein of phage through a soft linker, respectively, and thus two artificial transcription activators were created

    為了進一步提高表達載體表達外源蛋白的能力，我們把兩個人工轉錄激活結構域ah和vp2分別通過一個柔性的linker融合到噬菌體ci蛋白的c末端，構建了兩個人工轉錄激活因子。
  14. Two types of repeat sequence, a 15 - amino - acid ( eelcaqlcstppppi ) with 2 repeats and a 6 - amino - acid ( ppictp ) with 4 repeats, were firstly reported. 2. the characterization of meq gene product and its expression within the cells a recombinant baculovirus transfer vector pblubac4 - meq was constructed by cloning meq gene of marek ' s disease virus ( mdv ) ga strain into the baculovirus transfer vector pbluebac4 under the polyhedrin promoter

    此外，研究還發現了meq基因的兩類有趣的重復結構，其中一類是含15個氨基酸殘基（ eelcaqlcstppppi ）的結構，有2個重復，另一類是含6個氨基酸殘基（ ppictp ）的結構，共有4個重復，它們全部分佈在meq蛋白c -端的轉錄激活域內。
  15. All the components mentioned above were integrated into ped5, producing two vectors : per - ah and per - vp2. the two vectors were tested for their efficiency of expressing ifn - and seap reporter genes in comparison with perfrt, a vector similar to per - ah and per - vp2 except for lacking of artificial transcription activators

    以ifn -和seap報告基因對其表達效果進行檢測，結果per - ah表達外源蛋白的能力僅略高於perfrt （一個除了不含人工轉錄激活因子外，其餘都與per - ah或per - vp2完全相同的載體） 。
  16. The predicated amino acid sequences contain two conserved functional domains : a dna - binding domain ( hmg - box ) and a transactivation domain. the conserved motif of group b homology lies immediate adjacent to c - proximal region of the hmg - box. similar structure and identity of sox2 gene among mammals, birds, amphibians and reptiles suggest that sox2 gene have evolutionary conserved roles

    進一步分析表明，已巴灘2編碼的238個氨基酸多膚鏈含有兩個保守的功能區域:位於n端的hmg盒區（ 1一78aa ）和位於c端的轉錄激活區（ 131一236aa ） ，以及一個保守的特徵性b亞族同源區域（ 79一90aa ）與hmg盒區的c端相連。
  17. There is no characteristic in the amino acid sequence 63 - 152 and it is the piece that we want to delete to identify the function of the segment. ie180 gene mutants deleted the 64 - 151 amino acid was amplified by muti - pcr and were cloned by pmdist - vector. the clone plasmids were named pjmp1p3p2. the segment corresponding to the sequence of 1 - 1079 amino acid of the genbank sequence amplified by pcr, its clone plasmids was named pjmp1p2. the segment corresponding to the sequence of 454 - 1079 of genbank sequence amplified by pcr and its clone plasmids is named pjmp6p2 - three clone plasmids and pcdna3 were digested by restriction enzyme bamhi and hind, the gene segment of p1p2, p1p3p2, p6p2 were recycled

    本試驗應用dnamis及prosis軟體分別對genbank中登記號為no352564的ie180序列進行了蛋白質序列分析，結果表明其1 - 34段氨基酸序列具有典型helix - turn - helix特徵序列，並且富含酸性氨基酸d及e ，是典型的dna識別序列；富含絲氨酸序列的152 - 409氨基酸序列是一個與激活有關的、潛在的磷酸化位點； 454 - 696氨基酸區域是dna結合域； 64 - 151氨基酸片段沒有明顯的序列特徵；從中可看出ie180蛋白的1 - 1080氨基酸段具有典型的轉錄激活因子結構特徵。
  18. The comparative analysis of sequences indicated that the sequences of meq in different pathotypes are relatively conserved and the homology of the amino acid sequences is very high. the significant differences include two mutations in both mdv - 1 vaccine strains cvi988 / rispens and 814 strain : the deletion of a proline ( no. l93aa ), and this mutation is just exactly located in a 15 - amino - acid ( eelcaqlcstppppi ) repeat sequence within the c - terminal transactivation domain of meq protein ; and a point mutation with a shift from alanine ( a ) of all virulent strains to serine ( s ) was occurred on the no. 71 aa

    結果發現， mdv不同致病型的meq基因序列相對比較保守，它們相互間核苷酸和氨基酸序列的同源性均很高；但是，與所有七個致瘤性的mdv毒株相比，二個型弱毒疫苗cv1988 rispens株和814株均出現了兩個特徵性的突變：即第194位的p缺失性突變和第71位氨基酸由a變成了s的位點突變；缺失性突變恰恰位於meq基因中轉錄激活域內的一個多脯氨酸的重復序列（ pppp ）之中。
  19. Kyot2 lacked two lim domains from the c terminus and had a frameshift in the last exon, creating the rbp - j - binding region in the c terminus. kyotl had a negligible level of interaction with rbp - j. the binding site of kyot2 on rbp - j overlaps those of ramic and kyot2 repressed the rbp - j mediated transcriptional activation by ramic by competing with them for binding to rbp - j

    在肌肉母細胞系czc12內過表達kyoth時可阻斷轉錄激活物notch胞內區或ebnaz對rbp依賴性啟動子的轉錄激活作用，這種阻斷作用呈劑量依賴性，提示kyoth可與notch胞內區或ebnaz競爭rbp j上的結合位點，從而抑制二者的轉錄激活活性
  20. Lfy and lfy - like proteins from angiosperm contain a proline - rich region near the amino terminal and an acidic central region which is typical for transcriptional activators and may be important for the function of lfylike protein. the two domain exists in the variable regions of all lfy - like proteins

    與擬南芥leaf 』 y基因相比較，銀杏ginlfy和g毗基因沒有做為轉錄激活區域的位於氨基酸序列中間的酸性區和位於n端的富含脯氨酸區，但這兩個區域均位於leafy基因的非保守區。
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