Notch interaction with its ligands induces the cleavage of its intracellular domain ( ic ), and the notch ic translocates to the nucleus and binds to rbp - j, the mammalian homolog of su ( h ), to transactivate transcription of target genes such as e ( spl ) ( enhancer of split ), hesl ( hairy and enhancer of split ) and hes5 four notch receptors and their ligands are differentially and redundantly expressed in a variety of vertebrate tissues
它通過其識別序列（ cogtgggaa ）結合於受調控
基因的啟動子區，在轉錄激活因子的驅動下調節細胞分化和個體發育相關
基因的表達。在沒有n 。 tch胞內段的情況下， rbpj可與包含sm盯（ silencingmediatorforretlnoldandthyroidhormonereceptor ）和組蛋白去乙
酞化酶的轉錄輔助抑制復合物結合，當notch信號被激活時； rbpj可與n 。
Synthesis of mono - methyl - 5 - nitroisophthalate
硝
基異
酞酸單甲酯合成工藝研究
Standard specification for octyl ortho - phthalate ester plasticizers
辛
基正
酞酸酯增塑劑標準規范
1. two kinds of azo pigments with excellent photosensitivity, named as flurenone bisazo ( f - azo ) and oxazole bisazo ( o - azo ), are synthesized. the preparation of organic photoconductive blended materials and their photoconductivity in single - layered photoreceptors made from f - azo / titanium oxide phthalocyanine ( tiopc ) composite and o - azo / tiopc, respectively, are investigated
合成了芴酮
基偶氮（ f - azo ）與?唑
基偶氮（ o - azo ）兩種光敏性優良的偶氮化合物，並以此制備了芴酮
基偶氮
酞菁氧鈦和?唑
基偶氮
酞菁氧鈦復合光電導材料體系及其單層光電導體。
Study on the synthesis of phthalimidomethyl copper phthalocyanine
鄰苯二甲酰亞胺甲
基銅
酞菁的合成
The effect of hexadecy pyridine choride on the dissociation constants of thymol blue bromide, cresol red, o - ckesolphthalein and thymol blue, as well as their the colour - changing ranges were studied by spectrophotometry
探討了表面活性劑氯化十六烷
基吡啶形成的膠束對溴百里香酚藍、甲酚紅、鄰甲苯酚
酞和百里香酚藍離解反應的離解常數的影響，同時，也研究了該表面活性劑對上述四種酸堿指示劑變色范圍的影響。
Database of manufacturers producing acid, basic, direct, disperse, mordant, reactive, and solvent vat dyes and pigments for application in textiles, leather, plastics, and paper
-生產銷售母體為偶氮型蒽醌型
酞菁型等，活性
基為x型k型kn型km型ke型r型p型等的活性染料
Northern blot results show that nos. 66 - 1, 84, 89 - 1, 97, 108, 152, 175 and 233 have stronger signal in sp6 - tester than in sp6 - driver ; and no. 23 has weak signal only in sp6 - tester, nos. 94, 165, 172, 185 and 191 have similar hybridization signals in both sp6 - tester and sp6 - driver ; nos. 4, 17, 18, 28, 6 9, 101, 156 - 1, 157 - 1 and 183 do not reveal hybridization signals in both sp6 - tester and sp6 - driver ; the results of sequencing and blastn and blastx on ncbi indicate that no. 23 cdna ( 846bp ) has significant alignments with nicotiana tabacum mrna for elicitor inducible beta - 1 - glucanase nt - sube76, and arabidopsis thaliana clone 7119 for glycosyl hydrolase family 17 ( protein id : at5g55180. 1, supported by cdna : 7119, supported by cdna : gi _ l 87001 54 ) and arabidopsis thaliana beta - 1 - glucanase - like protein ( gi _ 2 1594590 ) ; no. 84 cdna ( 560bp ) has significant alignment with lotus corniculatus aspartate aminotransferase mrna ( complete cds length = 1685, gi | 2605931 | gb | af029898. 1 | af029898 ) for aspartate aminotransferase ; no. 89 - 1 cdna has significant alignment with arabidopsis tha
與同源性最高的擬南芥類似晚期胚胎發生高豐度蛋白比較，二者都具有lea 2結構域、保守分泌蛋白cog5608結構域和低復雜度區，都具有pkc磷酸化位點、酪蛋白激酶磷酸化位點、 n十四
酞化位點和酚胺化位點，所不同的是： （ ）在結構功能域上， 152全長cdna編碼的蛋白質序列中多了1個lea 2結構域、 l個保守分泌蛋白cog5608結構域和1個低復雜度區； （ 2 ）在功能位點上， 152全長cdna編碼的蛋白質具有酪氨酸硫酸化位點、多了l個酪氨酸激酶磷酸化位點和1個可能的天冬氨酸富集區，但沒有n糖
基化位點； （ 3 ）擬南芥類似晚期胚胎發生高豐度蛋白的lea 2結構域具有顯著性（ e
Metallophalocyanines ( mpcs ) are a kind of centrosymmetric planar organo - metallic molecules with an extensively delocalized two dimensional conjugated - electron system which show a relatively large third order optical nonlmearity, varying upon central metal atom substitution and other factors. other interesting properties of this molecule and many of its derivative products are their versatility, architectural flexibility and high environmental stability, which are very important requirements to implement photo - electronic applications
因其骨架結構特徵和可通過選擇中心離子、軸向配體和在
酞菁環上引入功能性取代
基等方法進行分子篩選與組裝得到具有特殊的物理化學性質和光、電、催化等功能的材料，而引起化學家和材料學家的濃厚興趣。
5, histone acetyltransferase gene ygcns and histone deacetylase gene yrpd3 were cloned and expressed, which has laid down a foundation for studying chromosome remodeling in vitro
5 ，我們克隆並純化了酵母中的組蛋白乙
酞基轉移酶
基因gcns和去乙
酞化酶
基因rpd3 。
6, we used gcn5 and rpd3 genes as probes to detect the homologous sequences in drosophila melanogaster by fluorescence in situ hybridization ( fish ). this work has provided useful information for the localization and cloning of related histone acetyltransferase and histone deacetylase genes in drosophila melanogaster
6 ，利用己獲得的酵母gcns和rpd3
基因為探針，對果蠅多線染色體進行原位雜交實驗，試圖找出與gcns和rpd3
基因同源的
基因片段。為今後克隆和分離果蠅中與乙
酞化和去乙酚化相關的
基因奠定
基礎。
A page gel, stained by the petiodic acid - schiff ' s method to reveal glycoproteins, further displayed that the bindng - protein was a glycoprotein belonging to lectin, which contained 17. 4 % ( w / w ) neutral carbohydrate content of the glycoprotein detected by the phenol / h2so4 method. peptide mapping was comparable to the reported protein in protein bank. the database homology search ( ncbi blast ) indicated that the binding - protein shared 70 - 80 % homogeneity to l - aspartate oxidase, aspartyl / glutamyl - trna ( asn / gln ) amidotransferase subunit b, glutamyl - trna reductase, histidyl - trna synthetase
連續梯度聚丙烯耽胺凝膠電泳、 sds一聚丙烯
酞胺凝膠電泳和等電聚焦的結果表明該蛋白分子量為1 「 . skda ，由二個相同的亞
基組成，亞
基分子量為」 . ikda ，等電點為8 . 25 .糖蛋白染色結合考馬斯亮藍染色的結果證實此結合蛋白是個糖蛋白，其中糖含量為17 . 44 % ，蛋白含量為82 . 56 % .凝集反應確定該糖蛋白也是一個凝集素
A aada2 cassette, encoding aminoglycoside adenylyltransferase, was found in 2 isolates of shigella sonnei, and a two cassettes array of dfra1, encoding dihydrofolate reductase, and aadala in one isolate of shigella sonnei, and another two cassettes array of dfra1 7 and aada5 in two isolates of shigella sonnei and shigella flexneri y - variant each, and a dfrv cassette in one isolate of shigella flexneri 6, respectively
對其可變區測序分析，其中2株宋內志賀菌i類整合子均攜帶1個
基因盒，為氨
基糖昔腺營
酞基轉移酶（ aminoglycosideadenylyltransferase ） az
基因（ aa朔2 ） ，編碼對鏈黴素的抗性。
Based on the above theory, the fluorinone - based azo was used to prepare the single - layer photoreceptors with fluorinone - based azo / tiopc composites in chapter iv, experimental data indicated that the photoconductivity of fluorinone - based azo / tiopc composite photoreceptors was improved in comparison with that of chlorodiane blue azo / tiopc composite photoreceptors, the amelioration was attributed to the more pronounced electron - acceptor characteristic of fluorinone - based azo, these results further confirmed the mechanism proposed for the synergetic enhancement and complementary effects in azo / tiopc composite systems
根據激發態下部分電荷轉移機理，本論文第四章選擇具有電子受體特徵比較明顯的芴酮
基偶氮制備了芴酮
基偶氮/
酞菁氧鈦復合單層光電導體，研究結果發現復合材料的光導性能比氯丹藍偶氮/
酞菁氧鈦復合體系有所提高，進一步證實了偶氮/
酞菁復合材料光導性能的協同增強效應的內在原因。
In order to prepare composites with the least dimerization, it is important to design and assemble the target mpc molecule with desired structure, such as peripheral or axial substitutional groups. the optical limiting effect of the composites is measured at 532nm with 8ns pulses. the influence of different mpc doped concentrations, central metal ions, substitutional groups, dimerization ratios, and matrix on the composites " optical limiting effect is studied
在此
基礎上，應用光限幅測試技術，系統地研究了無機
基金屬
酞菁復合固態材料的光限幅性能和金屬
酞菁配合物在復合體系中的光限幅機理，揭示了復合體系光限幅性能的
酞菁濃度效應、中心離子效應、取代
基效應和
基質效應，為金屬
酞菁分子設計和復合制備工藝優化提供了可靠參考依據和可能。
Sleep / waking cycle is a complex network modulation and many factors such as interleukin - 1 ( il - 1 ), tumor necrosis factor ( tnf ), growth hormone releasing hormone ( ghrh ), vasoactive intestina polypeptide ( vip ) and many conventional neurotransmitters such as serotonin ( 5 - ht ), acetylcholine ( ach ), norepinephrine ( ne ), dopamine ( da ) and gamma - aminobutyric acid ( gaba ) were involved in it. recent evidence has shown that no synthesized in neurons in several areas of the brain can induce the release of neurotransmitters. in the rat central nervous system, the anatomical distribution of nos - containing neurons is now well established, and it was reported that nos is co - localized with neurotransmitters well known for their involvement in sleep mechanisms, i. e. 5 - ht, ach, da and gaba
鄭州大學2003屆碩士畢業論文gaba受體激動劑消除no合成酶抑制劑對大鼠睡/醒周期的影響睡/醒周期的形成是一個復雜的網路調控的結果，體內許多因子都參與了這一調控網路，這些因子如白介素一1 （ il一1 ） 、腫瘤壞死因子（ tnf ） 、生長激素釋放激素（ ghrh ） 、血管活性腸膚（ vip ）以及經典的神經遞質如5一輕色氨（ 5一ht ） 、乙
酞膽堿（ ach ） 、去甲腎上腺素（ ne ） 、多巴胺（ da ）和卜氨
基丁酸（ gaba ）等，它們在睡眠的發生和調節中也發揮著重要作用。
A screening method that allows available, efficient and reliable selection of hydantoinase - positive micro - organisms was devised. the soil samples were collected from different region, which were enriched by using 5 - phenylhydantoin as the unique nitrogen. the first detection was through screening plates, the 23 candidate strains were further selected by detection of the medial product and final product
2 .建立了一個可行的篩選模型，從不同區域採集土樣，以5一苯
基乙內
酞服為唯一氮源進行土樣富集，通過平板篩選法進行初篩后，得到23株候選菌株，通過檢測中間產物和終產物的產生進行復篩，結果初步確定了1株乙內
酞脈酶產酶菌株，編號為bts11 。
Pcl ii had two mutations in nueleotide sequences and amino acid sequence compared with that of natural pcl ii. the effect of chemical modification of amino acid residues upon haemagglutination and mitogenic activity toward t - lymphocytes was investigated. modification of tyrosine ( 1 - acetylimidazole and 4 - nitrobenzenesulphonyl fluoride ) did not alter haemagglutination but decreased mitogenic activity by about one half
採用不同的方法對酪氨酸（ tyr ）進行了修飾:用勺r酚經基專一性試劑對硝基苯磺酞氟（ nbsf ）修飾pcln ，導致pcln促淋巴細胞有絲分裂活性大幅下降，表明巧r的酚經基對於此活性是必需的。
