酸性激活域 的英文怎麼說
中文拼音 [suānxìngjīhuóyù]
酸性激活域
英文
acidic activation domain- 酸 : 酸構詞成分。
- 性 : Ⅰ名詞1 (性格) nature; character; disposition 2 (性能; 性質) property; quality 3 (性別) sex ...
- 激 : Ⅰ動詞1 (水因受到阻礙或震蕩而向上涌) swash; surge; dash 2 (冷水突然刺激身體使得病) fall ill fr...
- 活 : Ⅰ動詞1 (生存; 有生命) live 2 [書面語](救活) save (the life of a person):活人無算 (of a goo...
- 域 : 名詞(在一定疆界內的地方; 疆域) land within certain boundaries; territory; region
- 酸性 : [化學] acidity; acidness; acerbic; acidic property酸性材料 acid material; 酸性促進劑 acid acceler...
- 激活 : activation; sensitization; activate; sensitize; active激活材料 active material; 激活劑 activating...
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The cyst cells enclosing spermatomeres maybe synthesize a kind of scf - like protein, which can recognize specially the c - kit receptor on the cellular membrane of spermatomeres. then c - kit is activated, dimerizing and autophosphorylating. at the same time, the tyrosine kinase domain of c - kit is activized, which phosphorylates the proteins that have sh2 domain
精母細胞周圍的囊細胞可能合成scf樣蛋白,特異地識別精母細胞膜上的c - kit受體,並刺激c - kit發生二聚化、自體磷酸化,激活胞內酪氨酸激酶活性,活化具有「 sh _ 2結構域」的靶蛋白,可能通過一系列信號級聯,最終激活與減數分裂的相關蛋白或基因。The predicated amino acid sequences contain two conserved functional domains : a dna - binding domain ( hmg - box ) and a transactivation domain. the conserved motif of group b homology lies immediate adjacent to c - proximal region of the hmg - box. similar structure and identity of sox2 gene among mammals, birds, amphibians and reptiles suggest that sox2 gene have evolutionary conserved roles
進一步分析表明,已巴灘2編碼的238個氨基酸多膚鏈含有兩個保守的功能區域:位於n端的hmg盒區( 1一78aa )和位於c端的轉錄激活區( 131一236aa ) ,以及一個保守的特徵性b亞族同源區域( 79一90aa )與hmg盒區的c端相連。There is no characteristic in the amino acid sequence 63 - 152 and it is the piece that we want to delete to identify the function of the segment. ie180 gene mutants deleted the 64 - 151 amino acid was amplified by muti - pcr and were cloned by pmdist - vector. the clone plasmids were named pjmp1p3p2. the segment corresponding to the sequence of 1 - 1079 amino acid of the genbank sequence amplified by pcr, its clone plasmids was named pjmp1p2. the segment corresponding to the sequence of 454 - 1079 of genbank sequence amplified by pcr and its clone plasmids is named pjmp6p2 - three clone plasmids and pcdna3 were digested by restriction enzyme bamhi and hind, the gene segment of p1p2, p1p3p2, p6p2 were recycled
本試驗應用dnamis及prosis軟體分別對genbank中登記號為no352564的ie180序列進行了蛋白質序列分析,結果表明其1 - 34段氨基酸序列具有典型helix - turn - helix特徵序列,並且富含酸性氨基酸d及e ,是典型的dna識別序列;富含絲氨酸序列的152 - 409氨基酸序列是一個與激活有關的、潛在的磷酸化位點; 454 - 696氨基酸區域是dna結合域; 64 - 151氨基酸片段沒有明顯的序列特徵;從中可看出ie180蛋白的1 - 1080氨基酸段具有典型的轉錄激活因子結構特徵。The comparative analysis of sequences indicated that the sequences of meq in different pathotypes are relatively conserved and the homology of the amino acid sequences is very high. the significant differences include two mutations in both mdv - 1 vaccine strains cvi988 / rispens and 814 strain : the deletion of a proline ( no. l93aa ), and this mutation is just exactly located in a 15 - amino - acid ( eelcaqlcstppppi ) repeat sequence within the c - terminal transactivation domain of meq protein ; and a point mutation with a shift from alanine ( a ) of all virulent strains to serine ( s ) was occurred on the no. 71 aa
結果發現, mdv不同致病型的meq基因序列相對比較保守,它們相互間核苷酸和氨基酸序列的同源性均很高;但是,與所有七個致瘤性的mdv毒株相比,二個型弱毒疫苗cv1988 rispens株和814株均出現了兩個特徵性的突變:即第194位的p缺失性突變和第71位氨基酸由a變成了s的位點突變;缺失性突變恰恰位於meq基因中轉錄激活域內的一個多脯氨酸的重復序列( pppp )之中。Trka, the high affinity ngf receptor, contains an intracellular domain with tyrosine kinase activity and an extracellular domain with three tandem leucine - rich motifs flanked by two cysteine clusters in their amino termini and two immunoglobulin - like domains in the more membrane - proximal region
膜外域含有8個亮氨酸的重復區域,其前後分別串聯著一組半胱氨酸殘基,緊挨細胞膜的是兩個c2 -型免疫球蛋白樣區ig和ig ;膜內域為酪氨酸激酶催化活性區。Cys - teine is in place of lysine at the usual conserved location but wnk kinases still have kinase activity, while for other protein kinases, the residue has frequently been mutated to eliminate the catalytic activity
該激酶家族成員在通常保守的位於激酶區域第二亞區的賴氨酸位點,賴氨酸被半胱氨酸所替代,但激酶的生物活性沒有發生變化。而其它蛋白激酶此位點的改變通常會喪失激酶生物活性。Lfy and lfy - like proteins from angiosperm contain a proline - rich region near the amino terminal and an acidic central region which is typical for transcriptional activators and may be important for the function of lfylike protein. the two domain exists in the variable regions of all lfy - like proteins
與擬南芥leaf 』 y基因相比較,銀杏ginlfy和g毗基因沒有做為轉錄激活區域的位於氨基酸序列中間的酸性區和位於n端的富含脯氨酸區,但這兩個區域均位於leafy基因的非保守區。分享友人