Dendritic cells ( dc ) is the most powerful apc, which can markedly increase the antigen - presentation capacity by maximizing the pepitide - mhc complexes on the cell surface and upregulating the co - stimulatory ligands b7 - 1 and b7 - 2, adhesion moleculees such as il - 12 that promote full activation of lymphocytes. full activation of antigen - specific t cells requires two signals - one signal coming via the tcr and the other signal through engagment of co - stimulatary molecules. t cells receiving one signal via their tcr are turned off by mhc ( major histocompatibility complex ), via t cell cd28 binding to b7 on the dc induce tlymphokine and t cell proliferatiion
T細胞介導的細胞免疫在控制腫瘤生長方面發揮著重要作用， t細胞在發揮抗瘤效應（分泌細胞因子和直接殺傷）之前必
須先經過活化，體內專職抗原提呈細胞（ apc ）細胞並使其活化，樹突狀細胞（ dendriticcell ， dc ）為t細胞的激活提供雙重信號， t細胞藉助tcr識別由dcmhc分子遞交的抗原肽后，通過tcr - cd3復合體傳遞抗原特異性識別信號（第一信號） ，以cd28為主的t細胞表面輔
佐分子識別dc表面b7分子，傳遞非特異性協同刺激信號（第二信號） ，在機體抗腫瘤免疫應答中處于核心地位。
Returns which require submission of supporting documents, e. g. during the relevant year, the taxpayer was operating a sole - proprietorship business that had a gross annual income of more than 500, 000 or he she claims full or partial exemption of his her employment income
須隨個別人士報稅表提交
佐證文件的個案，例如在有關年度該納稅人經營全年總收入超過500 ， 000元的獨資業務或納稅人就其薪俸入息申請全部或部分豁免徵稅。
Tax return - individuals ( bir 60 ) returns which require submission of supporting documents, e. g. during the relevant year, the taxpayer was operating a sole - proprietorship business that had a gross annual income of more than $ 500, 000 or he claims full or partial exemption of his employment income
須隨個別人士報稅表提交
佐證文件的個案，例如在有關年度該納稅人經營全年總收入超過500 ， 000元的獨資業務或納稅人就其薪俸入息申請全部或部分豁免徵稅。
The latter, mainly consists of tax data and financial data, is one of the required supporting documents to be furnished together with a tax return, that is, it has the same status as the tax computation and audited accounts, etc. simplified profits tax return and supplementary form are printed on a3 size paper and folded into four pages as previously
補充表格包括稅務資料及財務資料，亦即
佐證文件之一，
須與報稅表一併提交，其性質與稅款計算表及經審計帳目等相同。簡化利得稅報稅表及補充表格會印在同一張a3大小的紙上，摺成4頁，形式與以往相同。
Daguenet had made nana give him the days subsequent to the old miser s visits, and as the trader had to be at home by eight o clock in the morning, the young man would watch for his departure from zoes kitchen and would take his place, which was still quite warm, till ten o clock
達蓋內叫娜娜把他自己的日期安排在老吝嗇鬼的后一天，因為那個商人在第二天早上八點鐘，必
須回到自己家裡。這樣，達蓋內就可以在
佐愛的廚房裡窺伺著，等老吝嗇鬼一走，就鉆進他的暖烘烘的被窩里，一直睡到十點鐘然後，他再去辦自己的事情。
If the scan reveals nothing particular, but hearing still deteriorates, csf cytology or repeated mri scan should be performed
當第一次核磁共振檢查沒有發現異常，但聽力再度惡化時，則極
須再安排核磁共振檢查或腦脊髓液檢查以
佐證之。
Robert zoellick is president bush ' s choice to head the world bank. he is 53 years old and currently a vice chairman at goldman sachs, the new york investment bank
美國總統布希提名（注：不是擔任，只是提名。擔任行長
須經世行最高權力機構24人董事會的批準）
佐利克為世界銀行行長。
佐利克現年53歲，目前任紐約投資銀行旗下高盛集團副主席一職。
All franchised buses on southbound nathan road heading for tsim sha tsui will be diverted into public square street and westbound jordan road. 2
所有在彌敦道南行前往尖沙咀的專利巴士
須改行眾坊街及
佐敦道西行。
Different techniques can also be used to enhance the flavour of the meat, such as marinating it or giving it a crispy exterior. the pork belly is so tender and juicy that it melts in your mouth
此外，在搭配上亦可見廚師的心思，蔬菜的選擇與豬肉應能相輔相成，芡汁和調味
佐料亦
須帶出肉味的鮮香，方為上品！
" hospitals have to spend on it now in order to cut costs in administration and personnel in the long term, " argues mr crescenzo
「從長遠來看，醫院要想削減行政管理及人員成本，現在就必
須在it方面投入資金， 」克雷申
佐說。
No. the electronic profits tax return and the computer files of the supporting documents ( where the taxpayer is not a small business corporation ) must be sent together as attachments of the e - mail
否。電子利得稅報稅表及
佐證文件（如納稅人不是小型法團業務）的電腦檔案，必
須一併附加到電子郵件內遞交。
The above exemption and relief is, however, only granted upon application with supporting documents and a taxpayer seeking tax exemption relief is required to complete, as appropriate, section 4 i. e. tax credit under the arrangement for the avoidance of double taxation on income with the mainland or section 6 i. e. application for full partial exemption of income included under part 4. 1 of b. i. r. 60 of the appendix to tax return individuals
申請豁免及寬免必
須遞交
佐證文件並且填寫個別人士報稅表附錄的第4部分即根據內地與香港特別行政區所訂關于對所得避免雙重徵稅安排申請有關的稅收抵免或第6部分即申請將個別人士報稅表b . i . r .表格第60號第4 . 1部所列的全部或部分入息豁免徵稅。
In processing the claim for either exemption relief, the following copies of documents are usually required : -
在處理豁免寬免申索時，通常
須有下列
佐證文件：
We must however be careful not to take the match against arezzo for granted
無論如何我們必須小心，不能讓比賽向阿雷佐希望的方向發展。
