clonal expansion 中文意思是什麼
clonal expansion
解釋
克隆擴充-
Disruption of lipid rafts and caveolae by depleting cellular cholesterol with cholesterol - binding reagent, - methylcyclodextrin or filipin, blocks the igf - 1 receptor signaling in 3t3 - l1 preadipocyte. both hormone induced adipocyte differentiation and mitotic clonal expansion are inhibited by lipid rafts and caveolae disruption. however, a nonspecific lipid binding reagent, xylazine, does not affect adipocyte differentiation or mitotic expansing
利用膽固醇結合試劑，如甲基環糊精和菲律賓菌素，減少細胞膽固醇的含量，破壞細胞膜上脂質筏/質膜微囊的結構，抑制了igf - 1受體信號誘導的3t3 - l1前脂肪細胞的分化以及克隆擴增。 -
By inducing 3t3 - l1 preadipocyte with individual hormone, it was identified that the mitotic clonal expansion was induced only by insulin, not by 1 - isobutyl - 3 - methylxanthine or dexamethasone
有報道用藥物抑制了克隆擴增的同時抑制了細胞的分化。我們發現克隆擴增是僅由胰島素誘導引起的。 -
Upon the differentiation induction of 3t3 - l1 preadipocytes by hormone cocktail containing 1 - isobutyl - 3 - methylxanthine, dexamethasone and insulin, the preadipocytes undergo ~ 2 rounds of mitotic clonal expansion, which just precedes the adipogenic gene expression program and has been thought to be an essential early step for differentiation initiation
誘導分化的早期細胞會進行約兩輪的細胞分裂，被稱為克隆擴增。克隆擴增以前一直被認為可能有利於染色體的重構以易化分化所需要的基因表達，因此克隆擴增可能是3t3 l1前脂肪細胞分化所必需的過程。 -
Differentiating 3t3 - l1 preadipocytes undergo clonal expansion induced by acylation stimulating protein
前脂肪細胞分化為成熟脂肪細胞后的再增殖 -
Thus, it is evident that 3t3 - l1 preadipocytes could differentiate into adipocytes without dna synthesis and mitotic clonal expansion
這些結果說明克隆擴增和dna復制並不是3t3 l1前脂肪細胞分化的必需步驟。 -
However, significant fraction of 3t3 - l1 preadipocytes differentiated into adipocytes without the mitotic clonal expansion when the preadipocytes were induced with the combination of 1 - isobutyl - 3 - methylxanthine and dexamethasone
用地塞米松和ibmx對細胞進行誘導不發生克隆擴增，而細胞也能部分分化，分化形成的脂肪細胞未經過dna復制。 -
Furthermore, when normally induced 3t3 - l1 preadipocytes were treated with pd98059 ( an inhibitor of mek - 1 ), to block the activation of erk1 and 2, the mitotic clonal expansion was blocked, while adipocyte differentiation was not affected
我們用有絲分裂原激活蛋白激酶激酶（ mapkk / mek1 ）的抑制劑pd98059與誘導分化激素及藥物一起對細胞誘導分化，克隆擴增不發生，但細胞分化未受影響。
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