complement activation 中文意思是什麼
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It has been demonstrated that complement activating and cr2 cross - linking on b lymphocytes set up a bridge between innate and acquired immunity. the interaction of c3 and cd21 on b lymphocytes will benefit initiating immune response and regulating primary antibody response. cd21 / cd35 is important in the process of antibody avidity maturing, this is critical to b lymphocyte activation especially in the state of low antigen concentration
現己證實補體的活化以及b細胞表面crz的交聯在先天和獲得性免疫之間架起了重要的橋梁，表現為c3與b細胞cdzi的相互作用有利於啟動抗體應答反應，並對初級抗體應答反應有調節作用： cdzi cd35對于抗體的親和性成熟具有重要作用，在抗原濃度低的情況下，對于活化b細胞是至關重要的，而且mlgm （交聯有利於特異的低親和性b細胞對t細胞依賴性抗原和t細胞非依賴性抗原產生免疫應答。 -
We focused on the following aspects ; 1 ) we first assayed the expression of complement receptors and complement - associated molecules on distinct subsets of dendritic cells during their development in order to understand the physical basis of the sensitivity of dendritic cells to complement and its split products ; we next studied the effects of complement activation on the survival of dendritic cells during their development ; and finally examined the effects of the whole complement system, focusing on the ability of one of the split products of complement activation, c5a, and its first subcomponent - c1q, to influence chemotaxis of dendritic cells, as well as allo - t cell stimulatory activity of dc
我們通過免疫磁珠分離了兩種人dc前體，即髓系來源的單核細胞（ monocytes ， mo ）和淋巴系來源的漿細胞樣dc （ plasmaeytoiddendriticeells ， pdc ） ，對這兩個不同dc亞群進行體外誘導培養，使其處于不同的分化發育階段，然後檢測了其表達補體受體一cd35 （ cri ） 、 cd21 （ crz ） 、 cdilb （ cr3 ） 、 cdlle （ cr4 ） ，補體調控蛋白一cd46 、 cd55 、以及部分補體片斷分子受體一c3ar 、 csar 、 clqrp的水平。 -
Activation of the complement may lead to killing of the microorganisms by direct lysis effect of complement system or the phagocytosis by the enhancement of the attachment of microbes to the phagocyte ( opsonization ). low serun concentrations of mbl in man is the basis for a common opsonic defect associated with recurrent infection
它可選擇性識別多種病原體表面的糖結構，以不依賴抗體和c1q的方式激活補體，發揮溶破和間接調理功能，還能與吞噬細胞膠凝素受體結合而起直接調理作用。 -
Almost one - third of all proteases can be classified as serine proteases, including complement subcomponent clr / cls, mannose - associated serine proteases ( masps ), ovochymase, spermadhesin, type ii transmembrane serine proteases ( ttsps ) etc. these proteins are involved in diverse biological processes, including developmental processes such as complement activation, ovulation, fertilization, tissue remodeling, cellular migration, cancer invasion and metastasis, intestinal digestion, embryogenesis, or organogenesis
絲氨酸蛋白酶（ serineprotease ）是機體最重要的酶分子之一，約占機體蛋白酶的三分之一，我們較熟知的絲氨酸蛋白酶就包括補體組分c1r c1s 、甘露糖結合絲氨酸蛋白酶、 ovochymase 、 spermadhesin和型跨膜絲氨酸蛋白酶等，它們參與了補體活化、排卵、授精、組織重建、細胞遷移、腫瘤浸潤和轉移、消化、胚胎發育、器官形成等多項生理功能。 -
An array of regulatory proteins have been found, which inhibit the formation of central enzymes involved in early stages of the complement activation pathway. these include membrane cofactor protein ( mcp cd46 ), decay - accelerating factor protein ( daf cd5 5 ), complement receptor 1 ( cr1, cd35 ), as well as cd59, which inhibits formation of the membrane attack complex during later stages. these regulatory factors are widely expressed and abundant on many cells, and in fluids of reproductive system
目前發現，機體多種細胞以及生殖系統的體液中表達和分泌豐富的補體調控蛋白，包括作用於補體活化早期階段的cd55 、 cd46 、 cd35和作用於補體活化終末階段的cd59 ，它們分別通過抑制補體活化過程中關鍵的c3 、 c5轉化酶和抑制形成膜攻擊單位，抵抗補體對自身組織細胞的攻擊。 -
Standard practice for testing for alternative pathway complement activation in serum by solid materials
通過固體材料測試血清中替換途徑互補活化性的標準實施規程 -
In addition to direct killing, activation of the complement system results in the generation of numerous split products, which bind to complement receptors on various cells of the immune system, thereby modulating inflammation and mounting an immune response
補體系統除了補體的直接殺傷機制外，在補體活化過程中釋放的多種小片斷分子具有廣泛的生物學效應，包括趨化中性粒細胞和淋巴細胞、調理吞噬、參與調節細胞和體液免疫應答等等。 -
In this study, a novel strategy to inhibit the activation of the complement system has been developed. to get the purified clq as the target molecule for biopanning, the first step of our purification was to isolate the clq from clr2cls2 by affinity chromatography on igg - sepharose 4b column
本研究另闢蹊徑，以補體經典激活途徑始動分子c1q為靶標，採用噬菌體肽庫技術，親和篩選能與c1q結合的噬菌體克隆，研製可抑制補體激活的c1q模擬短肽。 -
Standard practice for testing for whole complement activation in serum by solid materials
用固體材料測試血漿中整個活性的標準操作規程 -
However, complement activation presents a potential threat to host cells, as inappropriate activation may lead to tissue damage in many diseases
然而，對機體來說，補體也具有潛在的威脅，其經過不適宜的活化后，可以導致機體多種組織的損傷。 -
As an important innate immune system, and as an important arm of the humoral immune response, the complement system is immediately ready to target and eliminate virus particles, to lysis those virions that have lipoprotein membranes, or to prevent it from entering host cells, or to marker them for destruction by other branch of the immune response. at the same time, the host normal tissue are protected from damaging by complement through recognizing the regulators of complement activation ( rca ) expressed on self cells
作為機體重要的天然免疫防禦系統及特異性體液免疫應答的重要效應系統，補體系統除了具有溶解、清除病毒等致病微生物，阻止病毒進入靶細胞，調理病毒的吞噬等重要功能外，還可通過「識別」自身組織細胞表面的補體活化調節蛋白來對自身細胞加以保護，使之不受侵害。 -
To answer this question, a bispecific, trifunctional antibody constructs which can not only target block virus incorporated rca, but also can induce complement activation by it ' s fc fragment were designed and constructed and iv the role of this kind of bispecific antibody in virus neutralization was studied. 1. to test our idea, human immunodeficient virus ( hiv ) and enveloped extracellular virus ( eev ) of vaccinia virus ( vv ) were selected in our study because of their complex immune evasion stratiges, their threaten to humans, and because both these two kinds of virus can escape complement attack by incorporating host rca into their envelope
以嚴重危害人類健康，且具有復雜免疫逃避機制的有包膜的hiv病毒及痘苗病毒的eev病毒為研究對象，首先對它們逃避補體攻擊的現象進行了驗證，探討了宿主膜補體調節蛋白cd55 、 cd59與hiv病毒及eev病毒免疫逃避的關系，評價了病毒結合的這兩種補體調節蛋白作為本研究提出的，通過消除病毒逃避補體攻擊的機制來恢復病毒對補體攻擊的敏感性，提高補體抗病毒效率這一抗病毒策略的靶點的可能性。 -
On binding to specific carbohydrate structures on the surface of a broad range of microorganisms, mbl can activate complement system through the activation of mbl - associated serine proteases ( masps ) in antibody - and clq - independent way
甘露聚糖結合凝集素（ mannan - bindinglectin ， mbl ）是c型凝集素超級家族中膠凝素家族成員。 -
2, by using the above system, we demonstrated that yelp3, yhelp3 and help3 were able to completely, dramatically and partially complement the growth defects and the slow activation of pho5 and ssa3 gene caused by the depletion of yelp3, respectively, while yhelpbhat " whose catalytic domain was partially de
7 、 h4ks一r對i功五藝p3 、力幾p3與少凡p3功能的影響大於h3k14一r ，表明體內組蛋白不同位點的乙酞化修飾對基因表達有不同的影響。 -
Cd59 prevents myocardial damage associated with the activation of human complement
59對補體介導的心肌缺血損傷的保護作用 -
Through different regulation pathway have been developed to inhibit the activation of complement, there is still not a satisfactory way which can make reasonable regulation to the activation of complement
因此，抗補體治療一直是補體學研究中的重要領域之一。人們先後嘗試過許多抑制補體激活的途徑，但都存在或多或少的問題。
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