cyclin dependent kinase 中文意思是什麼
cyclin dependent kinase
解釋
細胞周期蛋白依賴激酶-
As the cyclin dependent kinase, cdc2 may act at multiple levels during mitosis to repress ribosome biogenesis, which lead the biosynthesis to a relative silent phase, when the most of cell ' s energy expenditure is used in chromosome condensation, breakdown of the nuclear envelope, and formation of the mitotic spindle
作為cyclin依賴激酶， cdc2的激酶活性在很大程度上抑制了細胞的合成代謝，使細胞的蛋白合成進入了一個相對的靜止期，而細胞主要的能量則被應用於細胞分裂時的染色體的濃縮、核膜的降解、紡錘體的形成等。 -
Mpf is a complex that consists of the protein kinase p34cdc2 and the regulatory protein cycli b ; the protein kinase activity of p34cdc2 is strictly dependent on its association with cyclinb. in xenopus laevis eggs the absent of cyclin b, mpf will not be activited
Ca卜活化p34 」擬的機制第一步是結合cycinb ，並且處于磷酸化狀態，即thr14 、 tyrls和tlirl61都處于磷酸化狀態；第二步是cdc25磷酸酶通過是thr14 、 tyr15脫磷酸化而激活p34 」擬。 -
The protein level of p27 klpl increased at ih, decreased from 6 to 24h after 2gy, it decreased from 3 to 24 h after logy, and the level of p27kipl associated with cdk2 decreased, then lost its inhibition function to cyclin - dependent kinase
Eycline / enkz的負調控因子p27k ， p 』蛋白表達水平在zoy照射后lh略有增加， 6一9h開始下降; 10gy照射后3h開始下降，持續到24h ，可見，隨著ir劑量的加大和處理時間的延長， p27kip 『蛋白表達水平下降的程度加大。 -
In this study, we showed that the protein levels of the cyclin - dependent kinase inhibitor p21 rapidly increased in the one - cell staged fertilized eggs treated with pma. the cleavage from one - cell stage of the fertilized eggs into two - cell stage was inhibited
但研究表明p21結合cdc2的能力不如其他cdks ，其介導的g2 m期的調控是由於p21蛋白抑制cdk2 cyclina復合物的活性，下調cdc25磷酸酶活性，阻止cdc2tyr - 15的去磷酸化，降低mpf活性。
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