cystic fibrosis protein 中文意思是什麼
cystic fibrosis protein
解釋
囊性纖維變性蛋白,囊性纖維化蛋白質-
Cystic fibrosis is caused by mutations in the gene encoding an ion - transport protein, the cystic - fibrosis transmembrane conductance regulator ( cftr ). defective secretion of anions is the primary cause of many of the clinical manifestations of cystic fibrosis, including pancreatic insufficiency
囊性纖維化是由作為陰離子通道的跨膜電導調節器（ cftr ）的基因突變所致，而陰離子分泌缺損是囊性纖維化的多種臨床表現（包括胰腺功能缺陷）的主要原因。 -
Professor hsiao - chang chan is a leading authority in epithelial cell - related multidisciplinary research and has contributed significantly to a number of important discoveries, including a cell shrinkage - activated cation channel, a novel defensin molecule in the epididymis for sperm maturation and the role of a cell membrane protein, the cystic fibrosis transmembrane conductance regulator cftr, in fertility and infertility
陳小章教授是上皮細胞相關的跨學科研究權威學者，曾作出過多項突破性科學發現，包括細胞收縮激活的陽離子通道的發現、從附睪頭部分泌的一個新防禦及其對精子成熟的影響以及囊性纖維化跨膜電導調節器在生殖及不育中的角色。 -
The newly identified gene, nyd - sp27 has structural similarity to an isoform of phospholipase c. nyd - sp27 was expressed endogenously in human pancreatic - duct cells and upregulated in cystic fibrosis. researchers has proved that suppression of the gene resulted in augmentation of phospholipase - c - coupled calcium - ion release and protein kinase c activity, improvement in the amount of mutated cftr reaching the plasma membrane, and thus restoration of pancreatic anion secretion
Nyd - sp27內源性表達在人體的胰腺導管上皮細胞，並在囊性纖維化時表達增高，顯示該基因可能與病變有關。研究人員發現通過抑制該基因在人體囊性纖維化胰腺導管細胞中的表達，可以糾正缺陷的胰腺陰離子分泌。
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