dose dependent 中文意思是什麼

dose dependent 解釋
劑量依賴性
  • dose : n 1 （藥的）一服，一劑；藥量，劑量。2 苦藥，討厭的東西。3 （酒中的）配料，增味劑。4 （處罰等）一...
  • dependent : adj. 1. 依靠的，依賴的。2. 從屬的，隸屬的，【語法】從屬的。3. 由…決定的。4. 下垂的，懸吊的。n. 1. 受贍養者，靠人生活的人。2. 扈從，侍從。3. 依存[從屬]物。
  1. The he was strongly inhibited by sbti and apmsf, and very sensitive to pmsf, lbti, and tlck, while not sensitive to chymostatin, bestatin, leupeptin, tpck, pepstatin, nem and iam. all these results imply that brine shrimp he was most probably a trypsin - type serine protease. the he could be strongly inhibited by edta in a dose - dependent manner, and 50 mmol / l edta exhibited more than 56. 5 % inhibition

    對孵化酶純化樣品進行生化性質和酶性質分析發現，鹵蟲孵化酶的最適反應溫度約為40 ，最適ph為8 . 5左右；該孵化酶對p - apmsf 、 sbti極為敏感，對pmsf 、 lbti和tlck也非常敏感，但對chymostatin 、 leupeptin 、 pepstatin 、 bestatin 、 tpck 、 nem和iam不敏感，表明該酶極可能是一種屬于胰蛋白酶類型的絲氨酸蛋白酶。
  2. We showed here that axudl mrna expression was elevated by tgf - 1 treatment in a time and dose - dependent manner in hepg2 hepatoma cells and spc - a1 lung carcinomas cells, and also indicated that de novo protein synthesis was required for this response using the protein synthesis inhibitor cycloheximide, suggesting that axudl is a primary target of tgf - signalling

    在hepg2和spc - a1細胞中， tgf - 1能明顯誘導這兩種細胞中的axud1基因的表達，而且表現出時間和濃度的依賴效應。同時，利用第一軍醫大學博士學位論文蛋白質合成的特異抑制劑還發現， tgf一pl誘導的axudl基因的表達過程需要新的蛋白質的合成，提示axudl基因是tgf一p信號通路的一個主要靶分子。
  3. Mtt value, morphological characteristics under light and electron microscopy, dna gel electrophresis results, and hoechst33342 dying results show that inosine can protect nscs against apoptosis induced by hioi significantly in a dose dependent manner

    2的直接保護作用，通過mtt值的測定，光鏡及電鏡的形態觀察， hoechst33342染色后核形的觀察及dna凝膠電泳結果，發現肌昔可對hzoz誘導的c門
  4. According to the polarity, the residue was isolated with petroleum ether, chloroform, ethyl acetate, and n - buoh, respectively. the n - buoh fraction, confirmed as neuroactive component, was subjected to sephadex lh - 20 column chromatography to provide an extract fraction, as a buff powder, which could induce neurite outgrowth in rat pheochromocytoma pc12 cells in a dose - dependent manner up to 50 mg / l

    將菟絲子乾粉用75乙醇浸泡后，減壓蒸干后得到褐色漿狀物，經石油醚、氯仿、乙酸乙酯、正丁醇萃取，經柱層析后，再用葡聚糖凝膠對有效成份進一步純化，獲得了菟絲子中能誘導pc12細胞分化的活性組分。
  5. The cumulus expansion, cumulus cells dna fragmentation, oocyte meiotic maturation and degeneration were determined 44 h after incubation. snp inhibited cumulus expansion and cumulus cells dna fragmentation in a dose - dependent manner

    結果發現， snp可劑量依賴性地抑制卵丘細胞的擴展和dna片段化，同時抑制ceos中卵母細胞的減數分裂恢復，抑制m向m期轉變。
  6. Dissecting the prothoracic glands, by using silkworms " prothoracic glands in vitro culture and h - ecdysteroid - radioimmunoassay, the biological activities of those analog peptides were examined, and their active features, chemical parameters, as well as the relationship between structures and functions of those peptides were analyzed and compared. with an exception of 899808 having the sequence of awqdlsaw that affected like bom - ptsp, 899805 ( awqdlns ) and 899809 ( awqdlnsgaw ) partially stimulated ecdysteroidogenesis in a dose dependent manner, whereas 899803 ( dlnsaw ), 899804 ( awqdlnsa ), 899806 ( awqdln ) as well as 899807 ( awqdlnsawa ) had both stimulatory and inhibitory effects on ecdysteroidogenesis, depending on the concentrations

    研究結果表明，類似多肽89980呂（ awq uawaw ）的生物學功能與抑前胸腺肽的相同而且活性近似：類似多肽899805 （ awqdlns ） 899809 （ awqdlns … ）對家蠶前胸腺蛻皮激素的生物合成表現出隨濃度增加而增加的促進作用，而低濃度下幾乎不促進； 899803 （ dlnsawawl899804 （ awqdmsa ） 、 899806 （ awqdln ）和899807 （ awqdlnsawa ）類似多肽對家蠶前胸腺蛻皮激素的生物合成的促進和抑制作用與它們的濃度有著依賴關系。
  7. The ar rate of mouse sperm decreased with endotoxin concentration increasing. the ar rate of golden hamster sperm was in a dose - dependent manner at first and was the high

    0卜yml時達最高，隨后呈降低趨勢，對人精於隨內毒素濃度的增加而增加， 10
  8. The likelihood of deeloping asthma increased in a dose - dependent manner and was significant for eery number of antibiotic courses ( or 1. 21 for one or two, 1. 30 for three or four, and 1. 46 for more than four )

    哮喘的發生幾率與抗生素的使用之間存在劑量依賴關系，每多使用一次抗生素，都會增加哮喘發生風險（使用一或兩次的比值比為1 . 21 ，三或四次的比值比為1 . 30 ，四次以上的比值比為1 . 46 ） 。
  9. The effect of nociceptin on membrane current of sg neurons in the adult rat spinal dorsal horn under voltage clamp superfusion of nociceptin could induce an outward current on sg neurons of spinal dorsal hom at a holding potential of - 70 mv ; this action was dose - dependent with an ec $ o value of 0. 23 ^ m and hill coefficient of 1. 5

    Nociceptin在電壓鉗制下對成年大鼠脊髓背角sg神經元膜電流的影響在鉗制電壓為刁0mv的情況下，灌流給子nociceptin可以誘致脊髓背角sg神經元產生一外向電流並且呈濃度依賴性，它的ecs 。值為0二3卜m ， hill系數為l 5 。
  10. The results were as follows : ( l ) the pre - incubation of pmr induced the exocytosis of the cortical granules ( cgs ) in the oocytes and reduced the quantity of the microvillus on the surface of oocytes ; ( 2 ) the matrix of cg might migrate to the surface of plasma membrane of oocytes after pmr pre - treatment. ( 3 ) incubation of zona - free hamster eggs with spermatozoa pretreated with pmr a ntiserum was associated with a dose - dependent significant reduction in the number of spermatozoa binding to the oolemma, compared with a contraband with a dose - dependent reduction of the fertilization rate and the penetration index. the results indicate that mr of human sperm plays an important role in sperm - oocyte fusion and oocyte activation

    結果顯示： （ 1 ）人精子mr能夠誘發去透明帶金黃地鼠卵母細胞中皮質顆粒的胞吐，並引起卵母細胞膜表面微絨毛形態和數量發生改變； （ 2 ）皮質顆粒胞吐后，其內容物可結合到卵膜表面； （ 3 ）抗mr抗血清預處理精子可抑制精子與卵子的結合與融合，使受精率、穿透指數和結合指數下降，並均有劑量依賴性。以上結果提示，人精子mr在受精過程中起重要作用，其主要作用可能是介導精-卵膜融合併促進卵母細胞的活化。
  11. The cells were then stimulated with various concentrations and incubation times of oligochitosan to study dose - dependent and time - dependent manners. the effect of oligochitosan on the production of no released by raw264. 7 cells was evaluated by griess method, which was also used to evaluate the effect of nf - kb inhibitor on no production induced by oligochitosan. western blot was performed to detect the protein content of nf - k b in the nuclear extract

    本課題以小鼠單核/巨噬}炎魏細胞raw264 . 7為研究對象，觀察殼寡糖單獨作用於巨噬細胞對其產生no的影響，並初步探討了核轉錄因子一kappab （ nf一kb ）在這過程中的作用，旨在部分解釋殼寡糖對免疫系統調節作用的機理，為其在醫學上的應用提供理論依據。
  12. Professor fung said, " the data from the pre - clinical studies indicates that the anti - cancer product developed by ck life sciences has the ability to strengthen the immune system in tumor - bearing mice and suppress the growth of tumors in mice in a time - and dose - dependent manner - an encouraging result indeed.

    馮國培教授指出：一系列的臨床前測試初步顯示長江生命科技之抗癌產品確能增強免疫功能，亦能在一定劑量及時間下，控制癌腫瘤的生長，這是令人鼓舞的訊息。
  13. The binding of ifn - to hbc is readily detectable at as little as 0. 25 ng ifn - / well, increases in a cytokine dose - dependent manner, and saturates at around 2ng / well. free heparin, lmw heparin and other polysaccharides inhibit the binding of hbc to ifn - with significant

    工fn一y與肝素、低分子量肝素、 dxs 、巖藻聚糖及卡拉膠高親和力結合，而與cs一a 、 cs一c 、 ha 、 dx結合力極弱。
  14. The results showed that : significant increase in dna migration and comet frequency in the spleen, thymus, bone marrow and peripheral lymphocytes were induced after intraperitoneal treatment of mtx at a dose of 1. 25 ~ 5mg / kg. no obvious increase in dna single strand breaks was observed in the liver, kidney, testicle and stomach of the mice with the same treatment. the migration of nuclear dna and comet frequency of spleen, thymus, bone marrow and peripheral lymphocytes in the dose - response study showed a dose - dependent increase

    實驗結果：腹腔注射5mg kgmtx后3h可誘發小鼠體內脾細胞、骨髓細胞、胸腺細胞和外周血淋巴細胞的dna單鏈斷裂且隨時間延長損傷程度增大，於12h達到高峰，但未觀察到對肝、腎、胃和睪丸細胞的山窗民科大學碩士學位論文影響;核dna損傷程度隨著用藥劑量的增大而增大。
  15. Effects of 17 beta - estradiol on serotonin - induced dose - dependent contractions of in vitro canine coronary artery and enlightenment of supersensitivity phenomenon

    莫索尼定與可樂定對腎性高血壓大鼠動脈壓及心率作用的比較
  16. The originalities of this paper are : 1, development of a a flow cytometry - based assay for quantitative analysis of cellular proliferation and cytotoxicity in vitro ; 2, the soluble secretion of k. 562 cell lines reduce the number of pbmc, but promote the activity of pbmc in dose - dependent manner ; 3, soluble secretion of k562 cell lines can induce the no production by pbmc, but no only plays a part of the role of soluble secretion of k562 cell lines ; 4, establishing a in vitro model and giving some parameters for sreening and appraising anti - tumor medicine

    本研究的創新點在於： l 、建立了用流式細胞術定量測定細胞增殖和細胞毒性的直接檢測技術； 2發現k562可溶性分泌物劑量依賴性地使pbmc細胞數量減少但活性增加； 3 、 k562可溶性分泌物能誘導pbmc產生no ，但是no的作用並不等同於腫瘤上清的全部作用。 4 、為抗腫瘤藥物篩選提供了一個體外模型，並明確了一些篩選指標。
  17. The fracture risk is dose dependent and occurs rapidly after the start of treatment

    這種骨折是劑量依賴性的，並且在治療開始后很快發生。
  18. The antibody induced by peptide gwyydal abolished vegf - induced huvec growth in dose dependent which specifically express the kdr. moreover, both of the peptide gwyydal and vasavfysalve displaying on phage also inhibited the growth of huvec

    [結論]從噬菌體肽庫中篩選到了與抗體有高親和力的陽性噬菌體克隆，噬菌體表達的7 、 12肽gwyydal 、 vasavfysalve模擬了vegf的抗原表位，引起顯著的抗- vegf抗體反應。
  19. The results show that a kind of leydig ' s cells form hemolytic plaques obviously. the plaque area increases in response to lh stimuli in dose - dependent meaner and the signals of star mrna and protein were only shown in leydig cells with hemolytic plaque and intensity of the signals was in proportion to the plaque area ( amount of testosterone ) ; in other kind of leydig ' s cells neither hemolytic plaque nor the fluorescent signal could be seen even after stimulation of lh

    結果顯示：一類間質細胞形成溶血斑，而且這類間質細胞經lh刺激后，溶血斑的面積增大，並且都能夠檢測到starmrna及其蛋白信號，其star信號強弱與溶血斑的面積成正比；另一類間質細胞不能夠形成溶血斑，經lh刺激后，這類間質細胞周圍仍無明變化，在間質細胞中未能檢測到star信號的表達。
  20. There was a dose - dependent relationship between da release and the administered dosage of the drug. but the drug has showed no influence on da release from amy of male rats in 60min after injection

    但兩種濃度烏雞白鳳丸有效成分對雄鼠的amyda釋放在注射后60min內均未表現增加作用。
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