endostatin 中文意思是什麼

endostatin 解釋
恩度
  1. Studies of the crystal structure of endostatin have shown a compact globular fold, with one face particularly rich in arginine residues acting as a heparin - binding epitope, this site was recently shown to be involved in the inhibition of induced angiogenesis. experimental studies show that recombinant endostatin specifically inhibits the proliferation of endothelial cells in a dosedependent fashion. recombinant endostatin from bacteria is largely insoluble, but still efficient in arresting tu mor growth after injection into mice. intermittent therapy with recombinant bacterially produced endostatin reduces several experimental tumors, including lewis lung carcinoma, to a dormant state. no sign of drug induced resistance has been reported and, in the original study, the treatment dormancy appeared to persist even when therapy was discontinued. sowe regard endostatin as a promising anti - tumor drug

    許多研究表明重組內皮抑素特異性抑制內皮細胞增殖，而且這種抑制作用呈劑量依賴性。細菌表達產物內皮抑素大部分以不溶形式存在，將這種混懸液注射治療老鼠仍可以抑制腫瘤生長。于小鼠皮下重復注射內皮抑素重組蛋白，幾乎完全抑制鼠lewis肺癌等多種腫瘤生長，並無耐藥性產生，即使中斷治療腫瘤也不再復發。
  2. Cloning and sequencing of the fragment of human endostatin gene

    來自中間偃麥草基因組的類反轉錄轉座子片段的克隆及其特徵分析
  3. Experimental study on apoptosis of vascular endothelial cell induced by endostatin in vitro

    體外誘導血管內皮細胞凋亡的實驗研究
  4. Inhibition of liver tumor growth by combining endostatin gene delivery with radiotherapy

    轉染內皮抑素基因聯合放射治療對肝癌移植瘤生長的影響
  5. Construction of plant expression vector with human endostatin gene and transformation of tobacco

    利用人內皮抑素基因構建植物表達載體及對煙草的遺傳轉化
  6. 2d numerical simulation of effect of antiangiogenic factors angiostatin and endostatin on tumor - induced angiogenesis

    作用下腫瘤血管生成的二維數值模擬
  7. Experimental study the combination effects of egr - endostatin gene with radiotherapy on bladder tumor in nude mice model

    7901原位移植模型的構建及其生物學特性
  8. 5. the recombinant mouse endostatin gene was expressed in dh5a at under the condition of temperature induction

    5 .溫度誘導重組質粒pbv220一endostatin在宿主菌中表達外源蛋白。
  9. Vascular endothelial growth factor and the effects of endostatin on the inhibition of tumor angiogenesis in treating hepatocarcinomas

    血管內皮生長因子和內皮抑素在肝癌抗腫瘤相關血管治療中的作用
  10. Full - length clone of protein ht036 gene interacting with endostatin and its molecular mechanism in promoting the apoptosis of vascular endothelial cell

    036基因的全長克隆及其促血管上皮細胞凋亡的分子機制
  11. The generation of endostatin is catalyzed by proteolytic enzymes, that cleave peptide bonds within the protease - sensitive hinge region of the c - terminal domain

    特異性蛋白水解酶降解膠原c末端的蛋白酶敏感區，產生內皮抑素。
  12. 2. ecori / bamhi digested pcr products were inserted into the corresponding restriction site in the expression plasmid pbv220. construction of non - fusion expression plasmid pbv220 - endostatin

    用ecori和bamhi酶切endostatincdna的pcr產物，將其插入到質粒載體pbv220中相應的限制性酶切位點，構建非融合質粒表達載體pbv220 - endostatin 。
  13. 4. the seguence of cloned endostatin gene was confirmed with the dideoxy chain - termination method and is consistent with reported sequence of mouse endostatin

    4 .以雙脫氧末端終止法對重組質粒pbv220一endostatin進行測序，結果表明與己知小鼠endostatin基因序列一致。
  14. Total rna was extracted from hepatic cells of mouse. a ecori and bamhi restriction sites were introduced into endostatin gene at specific primer f r, and endostatin was amplified by rt - pcr, this endostatin gene contained bamhi and ecori restriction sites at its 5 " and 3 " ends respectively

    從小鼠肝臟細胞中提取總rna 。設計合成一對特異引物，分別帶有ecori和bamhi的限制性內切酶的識別位點。用rt - pcr法擴增endostatin的基因片段，在endostatin基因的兩側引入ecori和bamhi酶切位點。
  15. 3. pbv220 - endostatin was transformed into e. coli dh5a. the positive colony was screened and identified by pcr and restriction endonuclease digestion

    3 .將重組質粒轉化到克隆菌dh5a中，經pcr篩選和限制性內切酶鑒定，得到陽性克隆菌株。
  16. So, by inhibiting the neovascularization to prevent the tumor growth and metastasis is a strategy for tumor therapy. endostatin was isolated firstly from the conditioned media of a non - metastatic murine hemagioendothelioma cell line eoma by o ' reilly in 1997. endostatin is a 20kd c - terminal fragment of collagen xvh3

    1997年o ' rilly首次從小鼠內皮細胞瘤培養液中分離出內皮抑素（ endostatin ） ，氨基酸序列分析顯示此蛋白是膠原c末端的氨基酸片段，分子量為20kd 。
  17. Purification of the recombinant expressed endostatin in this work we have successfully cloned mouse endostatin gene, and constructed pbv220 - endostatin expression plasmid that is a non - fusion expression vector. the positive pbv220 - endostatin was transformed into dh5a, and expressed mouse endostatin protein successfully. this study is the basis of the endostatin gene - engineering production

    本文成功克隆鼠內皮抑素基因，構建了內皮抑素基因的原核表達載體pbv220一endostatin ，該載體為非融合性表達載體，將pbv22o一endostatin成功轉化到大腸桿菌表達菌dh5a中，並誘導表達了鼠內皮抑素蛋白，為基因工程方法生產內皮抑素奠定一定基礎。
  18. In the present thesis, it is mainly to express the human angiostatin ( kl - 3 ) in bombyx mori cells ( bmn ) and larvae of silkworms with baculovims expression vector system ( bevs ), to investigate the effect of human angiostatin ( kl - 3 ) on cell apoptosis in endothelial cells, and on vascular growth in chick embryo, and to elucidate cooperation between angiostatin and endostatin

    因此，在本實驗中我們用家蠶桿狀病毒表達系統表達了人血管抑素（ k1 - 3 ） ，並研究了其對內皮細胞凋亡和雞胚新生血管生長的影響，闡明了其與內皮抑素的協同作用。
  19. The target of endostatin is endothelia of the blood vessel, inhibiting the endothelial cell proliferation and migration, demonstrating an intense angiogenic activity

    實驗發現內皮抑素直接作用於血管內皮細胞，抑制血管內皮細胞增殖、遷移，具有強烈抑制血管生成活性。
  20. The purpose of my work was to clone and express of mouse endostatin gene, we construct a temperature - sensitive expression system : pbv220 - endostatin. the main work was as following : 1

    本文進行小鼠內皮抑素基因的克隆及表達，基因工程方法構建了鼠內皮抑素的溫敏型表達載體pbv220 - endostatin ，為此作了以下工作： 1
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