genotoxic 中文意思是什麼
genotoxic
解釋
具遺傳毒性的-
German standard methods for the examination of water, waste water and sludge - sub - animal testing group t - part 4 : determination of the genotoxic potential using the salmonella microsome test ames test
德國對水廢水和污泥的標準檢驗法.亞門動物試驗方法 -
The aglycone, steviol, exhibited greater acute toxicity than stevioside in hamsters but not in rats. steviol was clearly genotoxic after metabolic activation, inducing forward mutations in bacteria and gene mutations and chromosomal aberrations in lung fibroblasts of chinese hamsters
甜菊醇經過代謝活化后，基因毒性明顯，可引致細菌產生正向突變，以及使中國倉鼠的肺纖維原細胞產生基因突變和染色體變異。 -
Soil quality - assessment of genotoxic effects to higher plants - micronucleus test on vicia faba
土壤質量.高等植物遺傳毒性影響的評估.蠶豆的小核試驗 -
Exposure to genotoxic agents would trigger a series of comprehensive and complex responses in cells to counteract the abnormal conditions, which include the rapid activation of signal transduction pathways independent of the nuclear damage signal and late alteration of gene expression
自環境毒物接觸細胞開始，細胞就發生了一系列廣泛和復雜的應答反應以應對此不良環境。其中包括了即刻發生的並不依賴于核損傷信號的信號轉導通路的激活和較遲發生的基因表達的改變。 -
In order to understand the mechanism of mtx further and to investigate the genotoxic target organs, we studied the dna damage and the correlation with dose of mtx by using the alkaline single cell gel electrophoresis ( comet ) assay. liver, spleen, bone marrow, thymus, kidney, testicle, stomach and peripheral lymphocytes of mice were isolated at lh, 3h, 6h, 12h, 24h after 5mg / kg mtx intraperitoneal injection
為了進一步了解甲氨蝶呤（ mtx ）的作用機制，探測其作用的遺傳毒性靶器官，為應用mtx治療過程中的臨床監測和副作用防治提供理論依據，我們以小鼠為研究對象，用單細胞凝膠電泳技術檢測了mtx腹腔注射染毒1h 、 3h 、 6h 、 12h 、 24h后對肝、脾、骨髓、胸腺、腎、睪丸、胃和外周血淋巴細胞的dna損傷作用及損傷程度與mtx劑量間的關系。 -
Soluble genotoxic impurity
可溶性遺傳毒性雜質 -
Evaluation of genotoxic effects induced by organic pollutants in the yangtze river in nanjing section
長江南京段水體中有機污染物的遺傳毒性研究 -
Rapid responses occured when cells were exposed to genotoxic stresses : one is initiating dna damage checkpoint that leads to arrest in gl, in order to provide the cell with sufficient time to repair damaged dna, or leads to arrest in g2, in order to avoid defective chromosome happening mitosis. on the other hand, if damage to the genome is excessive, the cells initiating apoptosis, when damages cannot be repaired
這是因為細胞在受到諸如電離輻射等基因毒應激損傷時，細胞最先作出的細胞學反應：一，起始dnadamagecheckpoint使細胞周期阻滯（ arrest ）在g1期，贏得時間識別與修復損傷，避免損傷的dna進行錯誤的復制，或和阻滯在g2期，避免缺陷的染色體進一步分裂；二，損傷嚴重而修復無望啟動細胞死亡程序，清除那些帶有病變傾向的細胞危害機體。
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