neurodegeneration 中文意思是什麼

neurodegeneration 解釋
神經變性，神經退行性變
  • n : 1. 【羅馬數字】90〈N＝90000〉。2. 【化學】＝nitrogen. 3. ＝North（ern）。N ＝nuclear 核的：N-waste 核廢料。
  1. It may have a preventional function from alzheimer ' s disease. molecular biological studies are shown that apoe isoform has a isoform - specific role to neurodegeneration. apoe3 and apoei aid to sustain the stabilization of cytoskeleton protein tau, while apoe4hyperphosphorylates tau to destabilize the microtubule protein, which will make neurocyte easy to form neurofibrillary tangles in ad

    分子生物學研究發現， apoe異構體對神經細胞退化表現出異構體特異作用， apoe _ 3和apoe _ 2有助於維持微管的穩定性，而apoe _ 4則使tau蛋白超磷酸化，破壞微管的穩定性，使神經細胞易於形成神經纖維纏結。
  2. It is also important in several types of neurodegeneration and in macular degeneration ( the main cause of blindness in the old )

    它對幾個類型的神經性退化和黃斑變性（老年人失明的主要原因） ，也很重要。
  3. Because fddnp - pet binding differentiates among clinical entities with varying severity of cognitive decline, it may eventually prove useful in the early detection of neurodegeneration, they concluded

    研究人員總結，因為fddnp - pet能夠區分臨床上不同程度的認知力減退，它最終可能在神經退行性病變早期診斷中發揮重要作用。
  4. Excitotoxicity, associated with stroke and neurodegeneration, is triggered primarily by massive ca2 + influx arising from overactivation of glutamate receptor channels of the n - methyl - d - aspartate ( nmda ) subtype. although approaches to treatment of these disorders with antagonists of nmda receptor ( nr ) have been testified to be effective in animal models, successful therapy in humans was limited by the severe side effects of complete nr blockade for their space window and time window

    已有的nr受體拮抗劑或阻斷劑均為人工合成的小分子藥物，能彌散通過血腦屏障（空間窗過大） ，作用選擇性低，病變腦區及非病變腦區都會受到影響，而且由於神經元可逆性損害的「時間窗」極短，人們難以適時使用有效的神經保護藥物，這些均導致已有的藥物難以進入臨床。
  5. [ note : in neurodegeneration the main aggregates tend to form in other parts of the cell than the lysosome, but there is good evidence that this is a compensatory measure when neurons ' lysosomes stop working properly as a result of the more modest accumulation of lysosomal toxins, so if we fix the lysosome then the non - lysosomal aggregates should disappear naturally

    [附註：在神經性退化中，主要的堆積物往往在細胞的其他部分形成、而不是在溶酶體形成，但有很好的證據表明，這是一種補償措施：當神經原的溶酶體因溶酶體毒素積累到一定程度就停止工作，所以，如果我們修理了溶酶體，那麼非溶酶體的堆積物就會自然消失。
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