nogo 中文意思是什麼
nogo
解釋
蛋白質-
The expression of nogo - a and ngr in the brain of senile rat
在老年大鼠腦組織中的表達分佈 -
Nogo - 66 receptor, ngr, cloned in 2001, is a leucine - rich - repeat glycophosphatidylinositol - anchored membrane protein which mediates nogo - 66 inhibition of axonal outgrowth. both the long acidic amino - terminal domain and the nogo - 66 fragment have strong neurite growth inhibitory activity suggest that nogo - a has at least two inhibitory domains. northern blot, in situ hybridization, western blot and immunocytochemistry analyses show that in addition to oligodendrocytes, nogo - a mrna and nogo - a protein are also expressed in neurons in developing and adult brain and spinal cord, nogo - a is also found in peripheral organs such as heart and testis
Northernblot 、原位雜交、 westernblot和免疫組化結果證明： nogo amrna和nogo蛋白除了在cns的寡突膠質細胞中表達，還表達于發育階段和成年的腦、脊髓和外周神經節的某些神經元中，在外周組織如睪丸和心臟也有表達； nogoe在cns和pns以及多種外周組織中有廣泛分佈； nogo （除表達于腦和心臟外，在骨骼肌中有較高表達。 -
In mature neuronal network, nogo - a immunoreactive axons showed a string of beads which correspond to the varicosities or growth cones
Nogo a在成熟的神經元網狀的突起上，呈串珠樣分佈，這些結構推測為膨體或生長錐。 -
Then, nogo - a expression was gradually enriched in the distal segment and growth cone of the putative axon which grew much faster than other neurites
神經元突起形成過程中， nogo a主要表達于樹突近端，在軸突上隨著軸突的伸長逐漸表達于軸突遠端和生長錐。 -
Nogo - a was found in hippocampal neurons at different stages and is located in cytoplasm, membrane and neurites. nogo - a was detected at proximal part of all neurites before axon formation
結果提示nogo a在不同培養時間海馬神經元中均有表達，主要分佈在胞漿、胞膜和突起上。 -
The results indicate that nogo - a expressed in neuron may have function ( s ) in addition to the neurite growth inhibitory activity, and nogo - a may play a role in the course of neuronal differentiation such as neurite growth and synapse formation
以上結果提示nogo a在神經元中具有不同於抑制作用的其他功能，可能參與神經元突起生長、突觸形成等分化過程。 -
To investigate the potential function of nogo - a involved in neuronal development and differentiation, this study mainly used hippocampal neuron culture model, both in conventional and low - density condition, and immunohistochernical and western blot techniques. nogo - a expression pattern in hippocampal neurons at different stages and its subcellular distribution were explored by using specific antibody raised against nogo - a. pc12, 3t3 cells were also cultured as controls
為探討nogo a在神經元中的表達與神經元發育分化的關系，本研究藉助了海馬神經元常規培養方法和低密度條件下培養方法，應用針對nogo a的特異性抗體，採用免疫熒光細胞化學染色和westernblot方法，觀察了nogo a在體外培養的大鼠海馬神經元表達分佈模式，和不同培養時間nogo a亞細胞分佈的變化。 -
Nogo receptor and antagoist associated with spinal cord injury
受體和阻斷劑與脊髓損傷 -
Nogo protein expressed by cns myelin is regarded as a major repulsive factor for the failure of cns axon regeneration. the interest in this protein stems principally from the neurite growth promoting effect of a monoclonal antibody ( in - 1 ) rasied against ni - 250 which has been proved later to be a part of nogo - a
近年來認為髓鞘表達的ni - 250和ni - 35蛋白可能是cns軸突再生失敗的主要因素，用ni - 250作為免疫原制備的單克隆抗體in - 1可識別ni - 250和ni - 35 ， in - 1的體內研究結果奠定了ni - 250和ni - 35作為中樞神經再生中最重要的抑制因子的地位。 -
Go - nogo set
判定設定 -
Three major transcipts ( nogo - a, - b, - c ) originate from the nogo gene by alternative splicing
三種nogo分子都具有相同的188個氨基酸的c -末端，與reticulon家族成員高度同源。 -
Nogo - b is widely distributed in cns, pns and many peripheral tissues. nogo - c is expressed in brain, heart, and skeletal muscle. the wide expression of nogo - a, - b and - c suggests that the nogo family proteins may have function ( s ) in addition to neurite growth inhibition
Nogo人在別的組織，尤其是在神經元中的廣泛表達，以及nogo羽和nogo （的廣泛分佈，表明生理狀態下， nogo分子不僅僅是扮演抑制因子的角色，可能具有更多重要的功能不被人們認識。
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