pkb 中文意思是什麼
pkb
解釋
貝爾格萊德農業聯合企業-
Protein kinase b ( pkb, also named kinase akt ) is newly found as a ser - ine / threonine protein kinase
Pkb akt2在卵巢癌、胰腺癌細胞中過表達， pkb akt3在大腦和睪丸中表達。 -
There are two egfr signaling pathways, one is the classical ras / raf / mek / mapk pathway and the other is pi - 3 - k / pkb pathway. in this part, the phosphorylation and / or activity of some key molecules in these two signaling pathways in differently transfected h7721 cells were investigated. by means of specific antibodies combined with weste
Egf刺激后不同轉染細胞中的pkb活性、 p42 / 44mapk和mek磷酸化都明顯增加，其中gntv一s / h7721細胞pkb比活性、 p42 / 44mapk和mek磷酸化程度較mock細胞增加明顯，而gntv一as / h7721細胞中上述指標的增加程度則不及mock細胞。 -
The mouse fertilized egg is the most simple and natural mammalian model of cell cycle, there are few reports about the mechanism on the regulation of early development of mouse fertilized eggs especially the events of entry into m - phase. its the first time we report here that pkb exists and effects on g2 / m phase transition in mouse one - cell stage fertilized eggs
148 - 411是激酶區（催化域） ，和其它絲蘇氨酸蛋白激酶有較高的同源性，其中有一個保守的thr ，它位於308 、 309或305位；從412位起為c末端尾區（調節域） ，除pkb -外都有一個保守的ser ，位於473或474位。 -
Its well established pkb play an important role in cellular processes such as glucose metabolism, cell proliferation, apoptosis, and transcription and cell migration. there are recent indications that pkb could have a wide spread function in cell cycle regulation, but little is known about the effect of pkb on the regulation of mammalian cell cycle, especially the mouse fertilized eggs
Pkb akt的氨基酸序列測定揭示了它的c末端1 - 147位是調節區，稱為ah結構域，其中1 - 106位是ph結構域，這個區域包含約100個氨基酸，是血小板中pkc底物同源序列，且在pkb akt ， rasgtp ， msos和- spectrin中均被發現。 -
Sodn oligodeoxynucleotide of pkb : 5cac atg gac gtc aaa gct tcc aa3 ' each base of both sodn and saodn oligodeoxynucleotide was sulfurated. methods 1. superovulation, natural mating and eggs collection
Myt激酶的作用與cdc25相反，可以持續的使edcz的nlr14和t 」巧處于磷酸化狀態而抑制mpf的活性，從而抑制細胞周期進程。 -
Abtibidies goat anti - pkb polyclonal antibodies, antiphospho - tyr15 of cdc2 and antiphospho - ser216 of cdc25c polyclonal antibodies, alkaline phosphatase conjugated anti - goat secondary antibodies were purchased from santa cruz biotechnology
與edcz激酶增生細胞核抗原。一myt和c一myb基因互補的odn均可抑制平滑肌細胞的增生和移行。 -
Rt - pcr kit was from takara technology co. ltd. the sequence of the primer of pkb are shown below, together with all the sodn and saodn oligodeoxynucleotide were synthesized in takara technology co. ltd. pkb primers ; forward primer 5 ' cga gaa gcc gcg acc caa cac3 ' and reverse primer 5atg cac tac cgc cgg a3 "
有絲分裂前， cdcz / cy山b 、組蛋白h ;激酶的活性通過被weel和myt激酶磷酸化cdcz的1卜巧和thr14殘基而抑制。在有絲分裂期mpf可以被cdc25活化，這兩個位點被去磷酸化， cdc25是蛋白水解酶，可以使cdcz的t打巧脫離磷酸化。 -
B - actin primers : forward 5tcc tat cgg cct cct cct ac 3 " and reverse 5aga atg tag tcc gcc agg tc 3 ", designed for 200bps. saodn oligodeoxynucleotide of pkb : stac agc ctg aga gga cct acc tg3 "
在有絲分裂期， edc25經歷216位ser磷酸化同時其水解酶活性增強，活化的mpf磷酸化並活化edc25 ，形成正反饋，結果進一步活化mpf前體，活化的mpf促進細胞周期g2 / m期轉換。 -
The activity and expression of pkb increased in g2 / m phase, the mrna level also detectable contract to m ii oocytes
Pkb通過pi3k pkb途徑調節細胞代謝、促進蛋白合成、細胞生長、增殖，另外還有抗細胞凋亡作用。 -
Both cdc2 and cdc25 kinase activity were inhibi - ted by ly294002 and saodn oligodeoxynucleotide of pkb, which indicate that pkb may act as an initiator of g2 / m phase transition through the phosphoryla - tion of cdc25c at ser216
Pi3k介導的信號轉導通路中， pi3k pkb是獨立於其它通路的一個新發現的信號轉導通路，且與ras ， g蛋白， pkc等有復雜的交互作用。
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