serine protease domain 中文意思是什麼
serine protease domain
解釋
絲氨酸蛋白酶功能區-
For trypsin - like serine protease domain, the presence of his ( h ) - asp ( d ) - ser ( s ) representing a serine protease catalytic triad were at position of 283, 339, 436, respectively
Clsp在正常人外周血單核細胞來源的dc中有較強的表達，在分別經anti一cd40 、 tnf一a 、 lps刺激后的dc中，其表達水平均有所上升。 -
Hydrophobicity analysis predicted a 36 - residue hydrophobic signal peptide for secretion in the n - terminus, and no transmembrane region was present, suggesting it might be a type of secretory protein. some generic and atipical n - glycosylation sites were present in clsp, suggesting that the protein might represent a glycoprotein. the clsp protein contained one cub ( clr / cls, an embryonic sea urchin protein uegf, and bone morphogenetic protein i ) domain from 39th to 164th ammo acids, which is known to be involved in protein - protein or protein - substrate interaction, and a trypsin - like serine protease domain positioned from 244th to 483rd amino acids
Clsp分子具有補體樣絲氨酸蛋白酶的多種結構特徵，包括36個氨基酸組成的疏水信號膚，一個cub （ clr / cls ， anembryonicseaurehinproteinuegf ， andbonemorphogeneticproteinl ）結構域和一個胰酶樣絲氨酸蛋白酶結構域（ t汀psin一likeserineproteasedomain ）和幾個保守的糖基化位點等，沒有發現有跨膜區的存在。 -
The clsp gene is located approximately 3 kb and 90 kb centromeric to the clr and cls gene, respectively, and their genes form a short cluster in a region of about 115kb in 12pl3. the cluster gene arrangement and the sequence similarities of the cub and trypsin - like serine protease domain of clsp with other complement component 1 subcomponents supported a common evolutionary history by consecutive gene dup
同樣利用pcr檢測了clspmrna在人正常組織中的分佈，結果發現，人clspmrna廣泛表達於人正常組織中，如在胎盤、肝臟、腎臟、胰腺中表達量較高，在肺、脾、前列腺、卵巢、結腸、外周血組織有中度表達，而在心臟、骨骼肌、胸腺、翠 -
The cub domain and serine protease domain 01 clsp closely resembled the corresponding domains of clr ( 48 % and 58 % identity, respectively )
Clsp的cub結構域和絲氨酸蛋白酶結構域與clr相應的結構域之間的相似性（ simllarity ）分別為為48 %和58 % 。 -
Clr is a complement serine protease, composed of two cub ( clr / cls, an embryonic sea urchin protein uegf, and bone morphogenetic protein i ) domains, one egf domain and one serine protease domain
補體組分c1r含有兩個cub結構域，一個egf結構域和一個絲氨酸蛋白酶結構域，是一種絲氨酸蛋白酶原。
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