transcriptional activation domains 中文意思是什麼
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Kyot2 lacked two lim domains from the c terminus and had a frameshift in the last exon, creating the rbp - j - binding region in the c terminus. kyotl had a negligible level of interaction with rbp - j. the binding site of kyot2 on rbp - j overlaps those of ramic and kyot2 repressed the rbp - j mediated transcriptional activation by ramic by competing with them for binding to rbp - j
在肌肉母細胞系czc12內過表達kyoth時可阻斷轉錄激活物notch胞內區或ebnaz對rbp依賴性啟動子的轉錄激活作用，這種阻斷作用呈劑量依賴性，提示kyoth可與notch胞內區或ebnaz競爭rbp j上的結合位點，從而抑制二者的轉錄激活活性
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