tyrosine phosphorylation 中文意思是什麼
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The enzyme digest analysis shows that the arm repeats of c - terminal are conceivably conservative domain. in arc1 protein, there are some active sites including n - glycosylation sites, camp - and cgmp - dependent protein kinase phosphorylation sites, protein kinase c phosphorylation sites, casein kinase ii phosphorylation sites, tyrosine kinase phosphorylation sites, n - myristoylation sites, amidation sites and leucine zipper pattern. it probably take part in the signaling process of self - incompatibility
同時在arc1蛋白質中還發現了拉鏈結構和多個磷酸化位點，包括camp和cgmp依賴的蛋白激酶磷酸化位點、蛋白激酶c磷酸化位點、酪蛋白激酶磷酸化位點、酪氨酸激酶磷酸化位點、糖基化位點等，拉鏈結構為arc1蛋白之間及與其它蛋白的相互作用提供了可能，而磷酸化位點是arc1參與信號傳導過程所必需的。 -
Correspondingly, the egf binding affinity of surface egfr and the tyrosine auto - phosphorylation of immuno - precipitated egfr were also enhanced in gntv - s / h7721 cells and reduced in gntv - as / h7721 cells
Egfr的信號通路主要有兩條，一是ras - raf - mek一mapk經典途徑，另一條是新發現的pi一3k一pkb途徑。 -
Focal adhesion kinase tyrosine phosphorylation promotes rat hepatic fibrogenesis and its possible mechanism
黏著斑激酶酪氨酸磷酸化促大鼠肝纖維化形成及其可能機制 -
We also found that p1206 " 1 can be easily phosphorylated at tyrosine by epidermal growth factor ( egf ). tyrosine phosphorylation of p ! 20ctn strengthened bel - 7404 cells malignant behavior, and p120ctn translocated into nucleus
我們還發現，芒果貳有降低pi20ctn磷酸化的作用，其結果是bel一7404細胞粘附能力有所增強，遷移能力降低。 -
It is divided to extracellular and intracellular part by transmembrane domain. there are 13 n - glycosylation sites, 20 protein kinase c phosphorylation sites, 28 casein kinase ii phosphorylation sites, 4 tyrosine kinase phosphorylation sites and 15 n - myristoylation sites in the extracellular part of bt - r3 protein. an integrin recognition sequences rod lies in intracellular part of bt - r3 protein
跨膜區域（ tmd ）將它分為胞內和胞外兩個部分，它的胞外有13個潛在的糖基化位點， 20個蛋白激酶c的磷酸化位點， 28個酪蛋白激酶的磷酸化位點， 4個酪氨酸酶的磷酸化位點， 15個豆蔻（十四烷基）酰化位點；它的胞內有1個整合蛋白（ integrin ）識別位點。 -
Huangyal4 was complete nucleotide sequence of 1 854 bp with a nucleotide orf ( 1575 bp ), which encoded a protein consisting of 524 aa with molecular weight of 62. 2 kda and pi of 8. 96. strongly basic ( + ) amino acids, strongly acidic ( - ) amino acids, hydrophobic amino acids and polar amino acids of the protein were 13. 74 %, 11. 64 %, 36. 45 % and 22. 70 % respectively, and predicted secondary structure of the protein revealed many conserved domains such as n - glycosylation site, protein kinase c phosphorylation site, casein kinase ii phosphorylation site, n - myristoylation site, camp - and cgmp - dependent protein kinase phosphorylation site, tyrosine kinase phosphorylation site and a cytochrome p450 cysteine heme - iron ligand signature which was typical of cytochrome p450. a - helix and b - sheet of the protein is 47. 7 %, 45. 0 % respectively
Huangya14 ）為材料分離克隆到一個細胞色素p450基因，命名為bccyp86mf5 ， cdna全長1854bp ，含1575bp的完整開放閱讀框，編碼524個氨基酸，其編碼蛋白質的分子量為61 . 2kda 、等電點為8 . 96 ；堿性氨基酸、酸性氨基酸、疏水氨基酸和極性氨基酸分別占總氨基酸的13 . 74 、 11 . 64 、 36 . 45和22 . 70 ；二級結構預測包括n -糖基化位點、依賴于camp和cgmp的蛋白激酶磷酸化位點、蛋白激酶c磷酸化位點、酪蛋白激酶磷酸化位點、酪氨基酸激酶磷酸化位點、 n -豆蔻酰化位點和細胞色素p450的典型區域，半胱氨酸亞鐵血紅素配體信號區等， -螺旋和-折疊分別佔47 . 7 、 45 . 0 ；與bccyp86mf1基因的氨基酸序列同源性達到95 . 2 ，與擬南芥cyp86c4的達到85 . 9 。 -
Effects of free fatty acid on gene expression and protein tyrosine phosphorylation of leptin - receptor in rats
游離脂肪酸對大鼠瘦素受體基因表達及蛋白酪氨酸磷酸化的影響 -
However, the tyrosine - phosphorylation of stat3 was weak after pmsg treatment for 48 h followed by hcg treatment
但pmsg處理48小時後用hcg處理則使stat3的酪氨酸磷酸化減弱。 -
There were detectable expression and tyrosine - phosphorylation of stat3 in the decidual cells on days 5 and 6 of pregnancy
在妊娠第5 6天的蛻膜化基質細胞中可檢測到stat3表達及酪氨酸磷酸化。 -
Although there was an increase of tyrosine phoshporylation of stat3, no nuclear translocation was detected, indicating that stat3 may not act through the phosphorylation of tyrosine - 705
在黃體退化過程中， stat3很可能不是通過705位的酪氨酸磷酸化起作川。 -
Progesterone had no effects on stat3 expression and activation. after estrogen treatment, there were detectable stat3 mrna and immunostaining, and weak tyrosine - phosphorylation of stat3 in the luminal epithelium
雌激素處理后的子宮腔上皮上有stat3mrna和蛋白質表達，而且有較弱的酪氨酸磷酸化stat3的免疫染色。 -
The expression and tyrosine - phosphorylation of stat3 in the uterus of artificial decidualization were similar to that in day 8 uterus, implying that stat3 is closely related to decidualization
人工誘導蛻膜化的子宮中， stat3的表達及酪氨酸磷酸化形式與妊娠第8天的子宮中相似，表明stat3與小鼠的蛻膜化過程密切相關。 -
Ebv gp350 and c3d bind selectively to the same site on the cr2, epitopes on scr - 1 and scr - 2 are necessary for the binding. as soon as c3d binds to scr - 1 and scr - 2, cr2 may cross - link - 8 - to memberane ig and form a " co - capping " structure, moreover, activate b lymphocyte through cd19, a component of cd19 / cd21 / cd81 / leul3 complex, signaling and / or nucleolin tyrosine phosphorylation independent on cd 19 signaling pathway
配體與scr l和scr 2結合后， crz與細胞膜免疫球蛋白（ inlg ）形成「共帽」 kofthofcccptor ）結構，並經過d19c 21兒81肚u13復合體中d19的信號轉導以及不依賴于cd途徑的核仁素（ nucleolin ）酪氨酸磷酸化激活b細胞。 -
Spla 2 can significantly inhibits egf - induced egf receptorautophosphorylation, which also resulted in the inhibitionon egf - induced phospholipase d activation and tyrosine phosphorylation of phospholipase c - g 1. under the same condition, spla 2 can induce intracellular ceramidegeneration. moreover, exogenous ceramide analogs can also significantly inhibit such biologicalevent induced by egf, suggesting that ceramide may play an important role in spla 2 - induced cell death and the signaling events
在相同的條件下，分泌型磷脂酶a亦能誘導細胞內神經酰胺生2成的增加；外源性的神經酰胺類似物也能有效的抑製表皮生長因子誘導的這些生物事件，提示神經酰胺在分泌型磷脂酶a所介導的細胞死亡和信號傳導事件2中起著重要的作用。 -
Other studies show that the last pxp are critical for the signal transduction ; 4 ) a wvefi domain. it is termed as box2 which are identical in all the ghrs ; 5 ) there are also very conservative tyrosine in the cytoplasmic domain of all the ghrs, their phosphorylation is believed
以上比較分析表明ghrz具有ghr最重要的結構，其就是ghr 。但他們又有自己獨特的地方，因而和ghri分開來，屬于ghr不同的一個類群。 -
To make clear the hypothesis, a middle cerebral artery occlusion ( mcao ) and hypoxia and glucose - deprivation ( hgd ) ischemic models were used in in vivo and in vitro study, respectively. we first studied the cellular localization of kvl. 2 and the co - localization of kvl. 2 protein and vegf receptors flk - 1 and flt - 1, observed the effect of mcao on kvl. 2 expression and phosphrylation in the rat brain in vivo, then investigated the effect of vegf on ischemia / hypoxia cell damage and tyrosine phosphorylation of kvl. 2 in sh - sy5y cells. finally, in order to further elucidate the relationship between vegf ' s neuroprotection and its regulation on kvl. 2 phosphorylation, we used a specific antisense oligodeoxynucleotide ( odn ) to knockdown the expression of endogenous vegf to observe its role in ischemia / hypoxia cell damage and regulation of kvl. 2 phosphorylation
為了驗證上述假設，本文分別在整體和離體水平，採用大腦中動脈缺血（ middlecerebralarteryocclusion ， mcao ）和體外氧?糖剝奪（ hypoxiaandglucose - deprivation ， hgd ）缺血模型，首先了解了kv1 . 2蛋白的細胞定位及與vegf受體flk - 1和flt - 1的共存情況，觀察了整體mcao后缺血再灌不同時間大鼠腦內kv1 . 2蛋白的磷酸化水平變化，然後通過外源性給予vegf蛋白，在sh - sy5y細胞株上觀察其對缺血細胞存活率及kv1 . 2蛋白磷酸化水平的影響，最後利用vegf反義脫氧寡核苷酸（ oligodeoxynucleotide ， odn ）特異阻斷內源性vegf蛋白的表達，觀察內源性vegf蛋白在缺血細胞損傷及調節kv1 . 2蛋白磷酸化中的作用，以進一步明確vegf缺血保護效應與其調節kv1 . 2蛋白磷酸化之間的關系。 -
It has been demonstrated that kvl. 2, an isoform of delayed - rectifier potassium channel, is up - regulated in the ischemic neurons. besides, the activity of kvl. 2 is tyrosine phosphorylation dependent, phosphorylation of the tyrosine residue in the amino terminus of the channel by tyrosine kinases suppresses the channel current. therefore, we hypothesize that vegf could enhance the phosphorylation of kvl. 2, which results in an inhibition of / k
在介導i _ k的鉀通道家族中， kv1 . 2是其中的一個亞型，研究報道它在缺血神經元中的表達是增高的；此外，它的活性與其酪氨酸磷酸化水平相關，在其氨基末端的酪氨酸殘基經酪氨酸激酶磷酸化后可顯著降低其介導的電流的幅度。 -
The purposes of this study were to investigate the possible effects of exposure to 50hz mf on protein tyrosine phosphorylation, sapk signal pathway and p38 mapk signal pathway
所以本實驗以蛋白質酪氨酸磷酸化為起點，研究極低頻磁場對sapk途徑及p38mapk途徑的影響。 -
Effects of 50hz magnetic field on protein tyrosine phosphorylation in cultured cells protein cascade phosphorylation is one of the main modes of signal transduction pathway and protein activation in cells
4mt強度還可使61 7 、 105及112kda的蛋白質酪氨酸磷酸化發生改變，而0 smt強度卻使79 、 150kda的蛋白質酪氨酸磷酸化發生變化。 -
The expression, tyrosine - phosphorylation and nuclear translocation of stat3 were increased in the luminal and glandular epithelium of immature mice by pmsg treatments. hcg treatment also stimulated the tyrosine - phosphorylation of stat3 in the nuclei of luminal epithelium
用pmsg處理性未成熟的小鼠，可刺激子宮腔上皮和腺上皮中stat3的表達，並促進子宮腔上皮和腺上皮中的stat3發生酪氨酸磷酸化及核轉位。
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