活化信號 的英文怎麼說
中文拼音 [huóhuàxìnháo]
活化信號
英文
activation signals-
Comprehensive cellular responses was found in human amnion fl cells following exposure to low concentration of mnng, such as the lowering of dna replication fidelity resulted from alteration of dna polymerase profile ; activation of a lot of transcription factors, such as api, creb, nf - kb etc ; clustering of egfr ( epidermal growth factor receptor ) and tnfr ( tumor necrosis factor receptor ) and activation of camp - pka - creb and jnk / sapk signal pathways
我們發現，低劑量mnng處理后的人羊膜fl細胞有廣泛的細胞反應，並有多個信號轉導通路的激活和基因表達的改變。例如dna復制保真度下降， dna聚合酶譜發生改變，應用報告基因技術和底物磷酸化檢出技術證明細胞一系列轉錄因子如ap1 、 creb 、 nf b等被激活，細胞表面受體如表皮生長因子受體、腫瘤壞死因子受體發生聚簇，細胞信號轉導通路camp - pka - creb和jnk sapk被激活。T cell will be apopotosis, clone depletion and / or anergy, in turn inducing an antigen - specific tolerance. ctla4 ( cytotoxic t lymphocyte associated antigen 4 ), a prominent negative costimulator, can competitively bind with b7, and block b7 - cd28 pathway and t cell activation by producing inhibitory singals
Ctla4 （ cytotoxictlymphocyteassociatedantigen4 ）作為一種主要的共刺激負調節劑，可競爭性結合b7分子，阻斷b7 - cd28途徑、並通過產生抑制性信號使t細胞活化障礙。According to the research of physiological and biochemical indicators or index, components of soluble proteins, substrate protein of phosphorylation and the activity of protein kinase in low - temperature stress in the leaves of brassica oleracea l., we tried to find the law of the physiological and biochemical response of brassica oleracea l. leaf to low temperature. at the same time, discussion on the signal transduction can also provide further evidences for revealing the mechanism of low - temperature stress. the results are showed as follows : malondialdehyde ( mda ), superoxide dismutase ( sod ), ascorbate peroxidase ( asp ) and peroxidase ( pod ) activities were changed greatly after 0 ~ 30min ' s treating with low temperature
本文以甘藍葉片為材料，通過對低溫5脅迫下甘藍生理生化指標、可溶性蛋白組分以及磷酸化底物蛋白、蛋白激酶活性的研究，以期找出甘藍葉片對低溫脅迫的生理生化響應規律，為甘藍露地越冬栽培防範寒害提供理論指導，同時對低溫脅迫下甘藍逆境信號傳導進行了探討，從而為徹底弄清低溫脅迫機理提供進一步的證據，研究的主要結果如下：丙二醛含量（ mda ） 、超氧化物歧化酶（ sod ） 、抗壞血酸過氧化物酶（ asp ）和過氧化物酶（ pod ）活性在低溫處理0 30min發生顯著變化，低溫處理3min后，甘藍葉片內mda含量基本沒有變化，處理5min時出現第一個峰值，達到對照的104 . 10 ， 10min出現低谷，僅為對照的86 . 27 ，隨后再次上升， 30min時超過第一峰值，為對照的113 . 93 。Interestingly, inhibition of p38 mapk activation ( but not erk activation ) by its inhibitors or by expression of a dominant negative mutant of p38 mapk could effectively block the chemotactic effect of ( - arrestin2
P38mapk上游激酶ask1的顯性失活突變體也可以阻斷- arrestin2對趨化的增強作用。這說明是p38mapk而不是erk信號通路與- arrestin2對趨化的增強作用相關。P - liquid scintillation counting was used for analysis of erk and immunocytochemistry was used for the analysis of c - jun. all the data were analyzed with statistical treatment. the results were showed as follows : 1
分別做p液閃計數觀察erk的活性表達，做westernblot觀察jnk的表達量變化，免疫組化觀察cjun陽性信號的表達，並進行統計學處理，結果如下： 1Notch interaction with its ligands induces the cleavage of its intracellular domain ( ic ), and the notch ic translocates to the nucleus and binds to rbp - j, the mammalian homolog of su ( h ), to transactivate transcription of target genes such as e ( spl ) ( enhancer of split ), hesl ( hairy and enhancer of split ) and hes5 four notch receptors and their ligands are differentially and redundantly expressed in a variety of vertebrate tissues
它通過其識別序列（ cogtgggaa ）結合於受調控基因的啟動子區，在轉錄激活因子的驅動下調節細胞分化和個體發育相關基因的表達。在沒有n 。 tch胞內段的情況下， rbpj可與包含sm盯（ silencingmediatorforretlnoldandthyroidhormonereceptor ）和組蛋白去乙酞化酶的轉錄輔助抑制復合物結合，當notch信號被激活時； rbpj可與n 。Jak2 is one of the janus kinase family. it participates in the jak - stat signal transduction and plays roles in signal transduction of many cytokins and growth factors such as growth hormone, il and gm - csf. it plays essential roles in cellular functions, i. e. cell proliferation and differentiation
Jak2是janus激酶家族中的一員，參與jak - stat信號通路，介導諸如生長激素、白細胞介素、 gm - csf等細胞因子和生長因子的信號傳導，在細胞的增殖、分化等活動中起重要作用。The length of this phytase gene is1506bp interrupted once by an intron of 102bp in the 5 " part of the gene, this intron contains donor sequence - gtatgc, lariat sequence - gctgac and acceptor sequence - cag which are typically conserved sequence of the intron of fungal phytase gene. this gene encodes a peptide of 467amino acid residues with molecular weight of 51. 37kda, containing 13 potential n - glycosylation sites and a signal peptide sequence made up of 19 amino acid residues at n teminal of the peptide
核苷酸序列分析表明， pcr擴增產物中包含有完整的phya基因，該基因全長1506bp ，其中包含一段長102bp的內含子，該內含子具有真菌植酸酶基因內含子的特徵保守序列： donor序列? gtatgc ， lariat序列? gctgac及acceptor序列? cag 。該基因編碼467個氨基酸，理論分子量為51 . 37kda ，其上有13個潛在的n -糖基化位點， n端19個氨基酸為信號肽序列，植酸酶活性位點序列（ crvtfaqvlsrhgaryptdskgk ）位於氨基酸序列的+ 71 + 93 。This experiment was performed using the " yingqing " peach fruit and " chunxing " strawberry to study the changes of the main physiology - biochemistry characteristics and the microsome membrane ca + - atpase activities during the fruits ripening. the effects of ethylene, trifluoperizine ( tfp ) + ethylene and verapamil ( ver ) + ethylene treatments on the above changes were discussed. the objects of the thesis may further explore the role of calcium messenger in the ethylene signal transduction, and provide some new theoretical basis for further research of the microsome membrane ca2 + - atpase during the fruits ripening
本論文以迎慶桃和春星草莓為試材，研究了兩類果實采后在25和4條件下主要生理生化變化和ca ~ （ 2 + ） - atpase活性變化以及乙烯、鈣調素拮抗劑tfp +乙烯和鈣通道阻塞劑ver +乙烯處理對其的影響，為探討果實成熟衰老過程中，鈣信使系統在乙烯信號轉導中的作用，提供一定的理論依據，並為探索ca ~ （ 2 + ） - atpase在果實衰老中的作用及作用機制，提供實驗證據。After breast feeding, their descendents were fed with the same water, then killed them on the 1st, 8th, 15th, 22nd, 30th day after birth respectively and took out of the brains, stored at - 70. ( 2 ) measurement of the activity of pkc in brains : in cytoplasma ; took out the samples, cut the hippocampi into pieces and added buffer ( glucose 0. 32mol / l, hepes ph 7. 5 ), then shattered with ultrasound, centri - fuged at 27000g for ih at 4ti, moved the supernant into a new tube
本研究以細胞信號轉導途徑為線索，分別探討了pkc 、 erk 、 nos1等信號分子及即早基因（ c - fos ， c - jun ）在慢性鉛暴露小鼠腦細胞中的活性、蛋白表達及mrna表達的改變，以及鉛暴露小鼠記憶行為的變化，並將細胞中信號分子的改變與記憶功能改變結合進行分析以尋找一些內在規律。The expressed apoe protein in central neuronal system functions potentially in deposition and clearance of amyloidal peptide, sustaining the stabilization of microtubule proteins, cellular signal transduction, immune regulation, glucose metabolism and oxidation stress. apoe plays a key biological active role in vivo
中樞神經系統中的apoe對腦組織澱粉樣蛋白的沉積與清除、微管蛋白穩定性的維持、細胞信號轉導、免疫調節、葡萄糖代謝、氧化應激等都有潛在的作用， apoe在體內發揮十分重要的生物學活性。The cyst cells enclosing spermatomeres maybe synthesize a kind of scf - like protein, which can recognize specially the c - kit receptor on the cellular membrane of spermatomeres. then c - kit is activated, dimerizing and autophosphorylating. at the same time, the tyrosine kinase domain of c - kit is activized, which phosphorylates the proteins that have sh2 domain
精母細胞周圍的囊細胞可能合成scf樣蛋白，特異地識別精母細胞膜上的c - kit受體，並刺激c - kit發生二聚化、自體磷酸化，激活胞內酪氨酸激酶活性，活化具有「 sh _ 2結構域」的靶蛋白，可能通過一系列信號級聯，最終激活與減數分裂的相關蛋白或基因。Thioredoxins, an ubiquitous small proteins with a redox active disulfide bridge in its conserved motif - cp ( g ) pc -, are universally distributed in eucaryote and procaryote and have a molecular mass of approximately 12kda. by its disulfide / dithiol interchange reaction, this protein can transmit the regulatory signals to seleted targets ( enzymes, transcription factors etc ) and plays an important role in many plant physiological processes that includes photosynthesis, dna synthesis, transcription, protein disulfide reduction, protein repair, filamentous phage assembly, cell apoptosis and seeds germinating and so on
該蛋白質中含有保守的- cp （ g ） pc -氨基酸活性基序，該基序中的兩個半胱氨酸殘基可通過巰基二硫鍵的轉換實現其氧化還原狀態的變化和電子氫的傳遞，對細胞中與氧化還原相關的多種生理過程的調節起重要作用。通過同許多酶類、蛋白類、細胞內活性因子相藕連， trx能對光合作用、 dna復制、基因轉錄、細胞凋亡和生長、噬菌體組裝、蛋白質的還原和修復信號傳導等生理過程產生影響和調節。A novel chitosan ( cts ) - binding protein was isolated from the non - heading chinese cabbage leaves by chitosan affinity chromatography and partially characterized
說明cts在調控氨同化關健酶gdh和gs活性時，可能有ca 』 +信號系統的參與。Part ii effects of gnt - v on the phosphorylation and activity of egfr signaling molecules in h7721 cells modification of the n - glycan structure and function of egfr by the transfection of different gnt - v cdnas may lead to the alterations of the phosphorylation and activity in the downstream molecules of signal transduction
Gntv一s / h7721細胞p42 / 44mapk的磷酸化也較mock細胞增強，而gntv一as艦7721細胞則減弱，表明egfr的這兩條信號通路中信號分子的磷酸化或活力都受gnt一v的影響。The new technology of non - contact life - parameter detection is relative to that of the normal contact one, which uses microwave beams to illuminate the human subject, whose reflected wave will be modulated by the surface movement resulting from the physical activity. by this way, some parameters of the reflected wave, such as frequency and phase will be changed. if these changes can be detected, the life parameters such as respiration rate and heartbeat rate will be extracted from those changes
非接觸生命參數檢測是相對于常規的接觸式檢測而言的一種新技術，它利用微波束照射人體，其回波信號被人體生命活動引起的體表微動所調制，使得回波信號的某些參數（如頻率、相位）發生改變，檢測到這些變化就能從中提取出人體的生命參數（如呼吸或心跳） 。And the solutions of the three problems above are discussed : the solution to the simulcast interfering which is caused by the simulcast delay spread ( sds ) and the zero - beating is given in chapter four. based on the well understanding of the principle of ms - i / h / 0 in ipnp, the examples are given in chapter five on how to solve the problem of communication interruption between paging zones. through the analyse of signal switching between chengdu and deyang, the synchronization error between flex frames, and the bug in the multi - frequency roaming principle are pointed out
通過以上分析，文章探討了對上述三個問題的解決： ?對同播干擾問題，分別分析了時延差和零拍頻所造成同播干擾的客觀存在，探討了系統設計和網路優化的基本方法； ?對ipnp聯網障礙，提出了在掌握ipnp對各pncc作為輸入局歸屬局?輸出局（ ms ? i h o ）的靈活定義、以及相關參數配置原理的基礎上，分析聯網障礙的思路； ?對信號切換障礙，以成都和德陽兩地的局部廣域覆蓋為例，分析了flex幀失步和flex多頻漫遊原理設計缺陷的客觀存在，並探討了相關的解決方法和建議。Semg signal is the sum of bioelectrical activities that recorded from the skin of working muscle by surface electrodes. the change in semg signal could reflect motor units activation patters and the status of muscle fatigue in some certain degree. because it was non - invasive and local sensitive, the technique of semg signal analysis had become very important method in examining and evaluating human muscle function
Semg信號是從肌肉表面引導和記錄到的肌肉活動時神經肌肉系統生物電變化的一維時間序列信號，由於其檢測具有非損傷性和良好的局部性以及semg信號的變化在一定的程度上能夠反映運動單位的活動模式和肌肉疲勞的狀態，因此應用semg信號分析技術檢測和評價肌肉疲勞以及進一步探討其生理機制具有重要的理論意義和實用價值。Our previous work verified that heterotrimeric g protein was involved in regulation of pollen germination, tube growth and in the transmembrane mechanism of extracellular cam signal. in the present study, we provide further evidence that plc signaling pathway was presented in lily pollen and involved in extracellular cam signal transduction mechanism in pollen by molecular, biochemical and physiological approaches. these evidence included : the pip _ ( 2 ) - dependent plc activity was also detected in purified lily pollen protoplasts
為了給上述信號轉導過程提供進一步的證據，本文以百合花粉為材料，從plc活性的測定、 plc基因的克隆及其與花粉萌發的關系、以及plc活性被g蛋白和cam調控等方面，為肌醇磷脂系統參與花粉萌發和細胞外鈣調素的信號轉導過程進一步提供了分子生物學和生物化學的證據。Most current algorithms only work well in special conditions, because of the abnormity of signals in the real world. now, the research in the ica arises much passion and the ica has brought about many applications. the primary results the writer has got are as the following : after a whiting process, it is a key to find an orthogonal matrix to throw away the high - order redundant information between components
由於現實生活中信號十分不規則，目前提出的演算法大多隻能針對某類信號分離，鑒于目前在ica方面極大的研究熱情和強大的背景支持，作者對ica離線演算法做了一定研究，主要內容和工作包括如下: ica問題經過白化處理后，尋找去除高階相關的正交矩陣成為問題關鍵，而正交矩陣具有特殊的空間結構，組成它的每個列向量可視作rn中單位超球表面上一點，當這些點彼此垂直時，整體就組成一個正交矩陣。分享友人