無氧脫氫酶 的英文怎麼說
中文拼音 [wúyǎngtuōqīng]
無氧脫氫酶
英文
anaerobic dehydrogenase-
Which may provide the molecular basis for the inberine regulation of ll p - hsdl expression by glucocorticoids. secondiy, the regulation of l l 9 - hsdl expression and redutase activity by glucocorticoids was investigated in the primny cultured human chorionic trophoblast
整個妊娠過程中胎盤11 - hsd活性以氧化酶為主，使母體gc在進入胎兒循環前大部分被轉化為無活性的17 -羥- 11 -脫氫皮質酮，保證胎兒正常發育所需的激素濃度。The rat 20a - hydroxysteroid dehydrogenase ( 20ahsd ) belongs to a family member of aldo - ketoreductases used nadph as a cofactor and principally converts progesterone to 20a - hydroxyprogesterone as a lower or non - active hormone. thus 20ohsd acts as a molecular switch and makes the potent progesterone hormone into an inactive potent metabolite
大鼠20 -羥類固醇脫氫酶（ 20 - hydroxysteroiddehydrogenase ， 20 hsd ）屬于醛酮氧化還原酶系成員，在大鼠卵巢中以nadph為輔酶將孕酮轉變為低或無活性的20 -羥孕酮。L l6 - hsd2 is localized to the sppytiotrophoblast of the placenty providing a fimctional barrier protecting the fetus from matemal glucocorticoids. a sequence resembling glucocorticoid response element ( gre ) has been identified in the promoter region of the human l l0 - hsdl gene. glucocorticoids have been shown to induce the expression of 11p - hsdl in the hippomus in vitro " whereas controversial results were obtained in the hepatocyte
體內至少存在兩型11 - hsd ，在細胞完整的狀態下， 11 - hsd1主要為還原酶，它活化gc的代謝產物17 -羥- 11 -脫氫皮質酮（嚙齒類為脫氫皮質酮）為有活性的皮質醇（嚙齒類為皮質酮） ，而11 - hsd2為氧化酶，它催化皮質醇為無活性的17 -羥- 11 -脫氫皮質酮，因此11 - hsd1加強gc的作用，而11 - hsd2減弱gc的作用。Methods : in cultured lung explants without serum, the lipid component synthesis of pulmonary surfactant was evaluated in [ 3h ] - choline incorporation ; mrna content of phosphocholine cytidylyltransferase ( cct ) in lung explants was investigated in rt - pcr ; the changes of the ultrastructure of the at ii cells were observed with electron microscope ; the expression of nmdar1 subtype was observed in immunohistochemistry staining ; nitric oxide synthase ( nos ) activity, nitric oxide ( no ) content, superoxide dismutase ( sod ) level, malondialdehyde ( mda ) content and lactae dehydroase ( ldh ) level were determined by biochemistry methods. results : 1. influence of glutamate on synthesis of the lipid component of pulmonary surfactant ? with l - arginine, glu inhibited [ 3h ] - choline incorporation with good dose - dependence and time - dependence ; ( 2 ) mrna content of cct of the glu treatment groups was decreased ; ( 3 ) glu increases the release of ldh in cultured lung explants ; ( dwith electron microscope histochemistry, glu induced the changes of the ultrastruture of at ii iv cells
方法：採用成年大鼠肺組織無血清培養，運用[ ~ 3h ] -膽堿摻入法測定ps主要脂質磷脂酰膽堿（ pc ）合成量； rt - pcr擴增檢測肺組織中pc合成限速酶磷酸膽堿二胞苷酰基轉移酶（ cct ） mrna含量；透射電子顯微鏡法觀察肺泡型上皮細胞和ps系統超微結構的變化；免疫組織化學染色檢測glu的受體nmdar1亞單位的表達；生化測定肺組織乳酸脫氫酶（ ldh ）釋放量和肺組織勻漿中一氧化氮合酶（ nos ）活性、一氧化氮（ no ）生成量、超氧化物歧化酶（ sod ）水平以及丙二醛（ mda ）含量。分享友人