組蛋白修飾 的英文怎麼說

中文拼音 [zǔdànbáixiūshì]
組蛋白修飾 英文
histone modification
  • 組 : Ⅰ名詞1 （由不多的人員組成的單位） group 2 （姓氏） a surname Ⅱ動詞（組織） organize; form Ⅲ量詞（...
  • 蛋 : 名詞1. （鳥類或龜、蛇類所產的卵） egg 2. （像蛋形的東西） an egg-shaped thing 3. （辱罵之詞）
  • 白 : Ⅰ形容詞1 （似雪的顏色） white 2 （清楚; 明白; 弄明白） clear 3 （空的; 沒加他物的） pure; clear; ...
  • 修 : Ⅰ動詞1 （修飾） embellish; decorate 2 （修理; 整治） repair; mend; overhaul 3 （寫; 編寫） write;...
  • 飾 : Ⅰ動詞1 （裝飾） decorate; adorn; dress up; polish; cover up 2 （扮演） play the role of; act the ...
  • 蛋白 : 1. （卵中透明的膠狀物質） egg white; albumen; gary2. [生物化學] （蛋白質） protein
  1. These issues are essential to the understanding of the nature of cell cycle control, and to elucidating the roles of the histone acetylation modification in cell cycle regulation in eukaryotes. in this thesis, we studied the mechanisms of histone acetylation in cell cycle regulation in physarum polycephalum, a naturally synchronized slime mold. the results of this study confirmed that histone acetylation changed the expression of proteins related with the regulation of checkpoint conversion in cell cycle

    初步確定了組蛋白乙酰化在多頭絨泡菌細胞周期各轉換點的調控過程中對細胞周期調控相關蛋白表達水平的調節作用；了解了組蛋白乙酰化修飾對細胞周期各轉換點調控的作用途徑；建立了組蛋白乙酰化修飾對多頭絨泡菌細胞周期調控機制的基本模型。
  2. Human bone morphogenetic protein 3 is a member of tgf - b superfamily. lt can induce the differentiation of cartilage and bone tissue in mesenchymal cell. and is important to bone self - repairment and bone development during embryo morphogenesis. in addition, some other biological activities of hbmp - 3 have also been found. such as inducing development of embryo and stimulating differentiation of neural and blood cells. therefore, there is a great prospect in the use of hbmp - 3. there is trace content of hbmp - 3 in human body. it has been expressed in the expression system of eukaryotes and prokaryotes respectively, but its application is restricted because of defects in the process and modification after translation in prokaryotic cells and higher costs and lower yields existed in eukaryotic expression system

    人骨形成蛋白3 （ hbmp - 3 ）屬于tgf -超家族的一員，可以誘導間充質細胞分化為軟骨和骨，在胚胎時期骨骼發育和骨再生修復中起著重要的作用，而且對胚胎發育過程中中胚層的誘導和分化、造血組織的發育以及神經系統的發育和修復等都起著重要作用，因而hbmp - 3有廣闊的市場前景。它在人體內含量極微，盡管研究人員已經在原核細胞和真核細胞表達系統中分別進行了表達，但是由於原核表達系統缺乏翻譯后的加工修飾，真核表達系統存在成本高、產量低等特點，限制了其在臨床上的應用。
  3. In vivo, the two functional forms of rat mapllc3 with apparent mobilities of 18 and 16kda, termed lc3 - i and lc3 - ii, separately, were produced by a series of post - translational modifications including a characteristic c - terminal cleavage after the conserved glyl20 residue and this cleavage is essential for the membrane association of the 16kda rat map1lc3 protein.,

    其中18kda的map1lc3蛋白是微管相關蛋白1的輕鏈亞基，稱為lc3 - ；另一種16kda的map1lc3蛋白則是自噬體膜的必須組分，稱為lc3 - 。 lc3 -和lc3 -都是一系列翻譯后修飾的產物，其中特徵性的修飾是在保守gly120后發生的羧基端切割，此切割修飾對lc3 -定位於自噬體膜尤為重要。
  4. Mammalian cells are among the best systems for biopharmaceutical production due to their excellence in post - translational modifications. the products they produced are much more similar to their natural forms than those produced by prokaryotic, yeast or insect cells

    哺乳動物細胞表達系統具有準確的轉錄后修飾功能，表達的糖基化蛋白藥物在分子結構、理化性質和生物學功能方面最接近天然蛋白分子，是目前重組糖蛋白藥物生產的首選體系。
  5. As a test to determine whether such histone modification functionally affected plasticity, the researchers administered a drug to adult mice that would increase chemical modification of histone

    為了確定組蛋白的化學修飾是否對大腦可塑性產生功能上的影響，研究人員做了一個試驗，即給予成年鼠服用一種能夠增加組蛋白化學修飾的藥物。
  6. Recent data have demonstrated that the tails of histones h3 and h4 greatly reduce the speed of transcript elongation through a nucelosome, and tail acetylation suppresses this effect

    近來研究表明組蛋白尾部尤其是h3 、 h4四聚體的尾部強烈影響通過核小體的轉錄延伸速率，而尾部的乙酰化修飾可抑制這種影響。
  7. After the gst fusion proteins were processed by factor xa and were purified by gluta - thione - sepharose 4b affinity chromatography, the recombinant protein hbrp with high purification would be acquired. during the process of separation and purification, the every result which can show the location of the aim protein was monitored by 10 % sds - page. the gst fusion proteins acquired finally were examined and analyzed by the methods of western - blottin

    原核表達系統具有表達效率高，操作方便等特點，但缺乏翻譯? 3 ?后修飾，以pgex載體表達的gst hbrp融合蛋白，具有表達的蛋白穩定性好，在體外易於純化等優點，表達的gst融合蛋白可用gluthioneseph刪sc4b進一步純化一factorxa酶切與測分離，從而大量獲得hbrp重組蛋白，而且一次回收率大約在90以上。
  8. The last seven years have spawned a vast amount of data on the enzymes that remodel and modify nucleosomes and the rules governing how transcription factors interact with the epigenetic code on histones

    在過去的7年中，科學研究提供了大量的有關以下兩個方面的數據： （ 1 ）具有重構和修飾核小體功能的酶，以及（ 2 ）轉錄因子如何同組蛋白上的表觀遺傳編碼相互作用的機制。
  9. Combined with the results of histone deactylase inhibitor, it is suggested that histone acetylation plays an important role in hsp gene transcription regulation

    結合以上去乙酞化酶抑制劑的實驗結果，我們認為組蛋白乙酞化修飾參與了熱休克基因的表達調控。
  10. They also concluded that the closure of the critical period was associated with a decrease in the ability of isual experience to drie the histone modifications that are necessary for neural rewiring

    他們同時說道，神經系統的重新架構有賴于組蛋白的化學修飾，而視覺體驗刺激產生化學修飾的能力下降與臨界期的終止具有相關性。
  11. The activity of intact elongator complex is directed specifically toward the amino - terminal tails of histone h3 and h4, the predominant acetylation sites are lysine - 14 of histone h3 and lysine - 8 of histone h4

    完整的復合物可直接修飾組蛋白h3和h4尾部，其優先乙酰化位點是h3k14和h4k8 。
  12. 2, by using the above system, we demonstrated that yelp3, yhelp3 and help3 were able to completely, dramatically and partially complement the growth defects and the slow activation of pho5 and ssa3 gene caused by the depletion of yelp3, respectively, while yhelpbhat " whose catalytic domain was partially de

    7 、 h4ks一r對i功五藝p3 、力幾p3與少凡p3功能的影響大於h3k14一r ，表明體內組蛋白不同位點的乙酞化修飾對基因表達有不同的影響。
  13. Increasingly, however, modern drugs are being discovered through the precise targeting of a particular disease state dissected at the molecular level, and the drugs may be genes, the protein products of genes ( such as recombinant insulin or erythropoetin ), or small molecules created by design or diversity to modulate a specific disease process

    然而逐漸地，現代藥物是通過準確導向分子水平的特定疾病狀態發現的，藥物可以是基因、基因的蛋白產物（如重組胰島素或促紅細胞生成素）或設計製造及修飾的小分子以調節特殊的疾病過程。
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