Yherefore, many researchers have shown great concern with the development of vaccines to against schistosomiasis. at early stage, the research of vaccines of schitosomiasis was centered on dead vaccine and athenuated cercaria of schistosomes while molecular vaccine and athenuated cercaria of schistosomes while molecular vaccine is currently the focus of research with anti - infection protective immunity as its main concern. guan xiaohong and zhao weixian ( 1986 ) certified that the allergen of egg granulonma of schistosoma japonicum might firstly come from gut associated antigen ( gaa ) of schistosomula and adult worm and that daa had cross reaction with soluble egg antigen ( sea ) and membrane associated antigen ( maa ) ; and the gaa of schistosoma japonicum might play a sensitizing role in egg granuloma formation
Np30主動免疫c57bl 6對尾蚴攻擊感染產生42 . 05的保護力,
肝組織減卵率為66 . 63 ; balb c和昆明種小鼠的保護率分別為39 . 53和50 . 46 ;免疫山羊可誘導42 . 78的減蟲率,
肝組織減卵率為35 . 83 ,糞減卵率為25 ,並可明顯抑制
肝臟蟲卵肉
芽腫的大小,肉
芽腫數量明顯減少,纖維化減輕,體重明顯增加,因此np30是南京醫科大學博士學位論文很有希望的抗日本血吸蟲病疫苗侯選分子。
Hepatic granulomas most commonly due to sarcoidosis and tuberculosis.
肝肉
芽腫多由肉樣瘤病及結核病引起。
Imaging demonstrated a diffusely abnormal liver, and a liver biopsy revealed a fibrosing granulomatous process infiltrating and replacing liver parenchyma
影像表現異常的彌漫性
肝細胞脂肪變性,
肝活檢顯示進展性纖維化肉
芽腫浸潤
肝實質。
It has been confirmed that np30 has sensitizing effect on formation of hepatic egg granulomas in mouse model for hepatic egg granuloma of schistosoma japonicum ; immunization with np30 in kunming mice, c57bl / 6 mice and goats obtained worm reduction of 50. 46 %, 41. 67 % and 42. 78 %, respectively. np30 possesses effects of both anti - fecundity and anti - embryonation immunity on female worms of s. japonicum. moreover, np30 plays a significant down - modulatory role to hepatic granuloma and fibrosis ( the diameter, area and volume of egg granuloma were all significantly less than those of control ; the contents of type i, iii of collagen and fibronectin were also significantly less than those of control )
已對np30分子進行了較為廣泛的研究,應用小鼠日本血吸蟲
肝肉
芽腫模型證實np30對蟲卵肉
芽腫的形成具有致敏作用;對感染宿主(昆明種小鼠、 c57bl / 6小鼠和山羊)具有較好的免疫保護作用(減蟲率分別為50 . 46 、 41 . 67和42 . 78 ) ;用np30主動免疫小鼠具有抗雌蟲生殖產卵和抗卵胚發育的雙重功效;另外,還對血吸蟲病肉
芽腫和
肝纖維化有明顯的負調節作用(蟲卵肉
芽腫的直徑、面積和體積均明顯小於對照組,
肝組織、型膠原及纖維連接蛋白含量均低於對照組) 。
This is the first case of granulomatous infiltration of the liver replacing normal hepatic parenchyma
這是第一例報道的肉
芽腫性浸潤
肝實質移植案例。
Prevention on diethylnitrosamine - induced hepatocarcinogenesis by selenium - enriched malt in rats
富硒麥芽預防二乙基亞硝胺誘發大鼠肝癌的研究