胰纖維化 的英文怎麼說
中文拼音 [yíxiānwéihuà]
胰纖維化
英文
pancreatic fibrosis-
The recombinants were constructed by transforming ppic9 a - xynb into p. pastoris gs115. the assay results revealed that the xylanase gene xynb was overexpressed and secreted effectually in p. pastoris. in 3l fermentor the expression level of xylanase xynba exceeded 1200iu / ml and the expressed xylanase had normal bioactivity. the molecule weight of xynba was determined as about 31kd which is higher than 23kd of original enzyme xynb from streptomyces olivaceoviridis a1. xynbb was gotten by deglycasylation of xynba, whose molecule weight returned to 23kd. we comparised the enzymatic properties of xynba expressed in p. pastoris, xynbb deglycasylated from xynba and xynb produced from streptomyces olivaceoviridis al : there was little difference among the three enzymes on optimal ph, the optimal ph of xynb and xynba were both 5. 2, the optimal ph of xynbb was 5. 0 ; the optimal temperature of xynb and xynba were both 60 c, while the optimal temperature of xynbb was 50 ? ; because of glycosylation the thermal stability of xynba was better than xynb and xynbb ; the specific activity of xynba and xynbb were 883. 88iu / mg and 832. 5hu / mg respectively, which were both lower than 2814. 45iu / mg of xynb ; the km values of xynb and xynba were similar to each other which were 21. 56 ( g / kg ) and 20. 87 ( g / kg ), while the km value of xynbb was 27. 10 ( g / kg ) ; the fmax of xynba and xynbb were 4568umol / mg. min and 5329umol / mg. min respectively which were lower than 27623 umol / mg. min of xynb ; additionally all of the three enzymes did not display cellulase activity. they all had well resistance to pepsion and trypsin, and were not sensitive to metal iron, surface active agent and chelating agent. the analysis of different xylans enzymatic hydrolysate revealed : by xynba, that the main constitutions of enzymatic hydrolysate of birch wood xylans were xylotriose and xyloquaiose, which account for 68. 43 % and 16. 50 % respectively, additionally there was 11. 79 % of xylobiose ; the main constitutions of enzymatic hydrolysate of corncobs xylans were xylobiose and xylotriose, which account for 81. 78 % and 11. 55 %. the result indicated that this xylanase was a kind of 1, 4 - b - d - xylanohydrolase and was fit to used in industrial procession of xylooligosacc harides
進一步對xynba進行了脫糖基化處理得到xynbb ，其分子量恢復到23kd ，證明xynba是糖基化蛋白。通過對畢赤酵母重組表達的木聚糖酶xynba 、脫糖基化的木聚糖酶xynbb以及橄欖綠鏈黴菌a1所產原酶xynb之間酶學性質的比較發現：三種酶的最適ph差異不大， xynb和xynba均為5 . 2 ， xynbb為5 . 0 ； xynb和xynba的最適溫度均為60 ， xynbb降為50 ：在耐熱性上， xynba由於糖基化作用熱穩定性明顯高於未糖基化的xynb和xynbb ； xynba和xynbb的比活性分別為883 . 88iu mg和832 . 51iu mg ，明顯低於原酶的比活2814 . 45iu mg ； xynb和xynba的km值相當，分別為21 . 56 （ g kg ）和20 . 87 （ g kg ） ，而xynbb的km值較大為27 . 10 （ g kg ） ； xynba和xynbb的vmax相差不大，分別為4568 mol mg ? min和5329 mol mg ? min ，明顯低於xynb的27623 mol mg ? min此外三種酶均無纖維素酶活性，對胃蛋白酶和胰蛋白酶有很好的抗性，且對作用環境中的各種離子、表面活性劑、螯合劑不敏感。通過對不同木聚糖的酶解產物的糖份分析發現：以樺木木聚糖為底物時，酶解產物主要為木三糖和木四糖，含量分別為68 . 43和16 . 50 ，另外還含有11 . 79的木二糖；以玉米芯木聚糖為底物時，酶解產物主要為木二糖和木三糖，含量分別為81 . 78和11 . 55 。In this experiment, the method of trypsin digestion was improved, and that several kinds of mouse fibroblasts and porcine fibroblasts were successfully dissociated and cultured
實驗中改進了胰蛋白酶消化法，成功地分離和培養了多種鼠成纖維細胞和多種豬成纖維細胞。This year, all funds raised from the championships will be donated to the mid wales division of the cystic fibrosis trust
今年錦標賽籌得的資金將會捐獻給治療囊腫性纖維化（一種遺傳性胰腺病）的基金。Cystic fibrosis is caused by mutations in the gene encoding an ion - transport protein, the cystic - fibrosis transmembrane conductance regulator ( cftr ). defective secretion of anions is the primary cause of many of the clinical manifestations of cystic fibrosis, including pancreatic insufficiency
囊性纖維化是由作為陰離子通道的跨膜電導調節器（ cftr ）的基因突變所致，而陰離子分泌缺損是囊性纖維化的多種臨床表現（包括胰腺功能缺陷）的主要原因。3 ) dispased cold digested single cell is the best to obtain pured epithelial cell line ; it is appropriate to obtain pured fibroblast cell line that repeated attachment and the pured method to their different sensibility to trypsin
對于秦川牛皮膚上皮細胞與成纖維細胞的純化： dispase冷消化單細胞培養的效果最佳，可獲得純化的上皮細胞系，而根據二者對胰蛋白酶的敏感性不同的分離方法、反復貼壁法適宜於獲得純化的成纖維細胞系。The pancreatic stellate cells ( pscs ) are now established as key cells in fibrogenesis, particularly when activated either directly by toxic factors associated with pancreatitis ( such as ethanol, its metabolites or oxidant stress ) or by cytokines released during pancreatic necroinflammation
胰臟的星狀細胞現在已經被認為是在纖維形成中的關鍵性細胞，特別是在與胰腺炎相關的毒性因子（如酒精的代謝產物或氧化劑應激物）或在胰臟壞死性炎癥時釋放細胞因子的直接激活情況下。The newly identified gene, nyd - sp27 has structural similarity to an isoform of phospholipase c. nyd - sp27 was expressed endogenously in human pancreatic - duct cells and upregulated in cystic fibrosis. researchers has proved that suppression of the gene resulted in augmentation of phospholipase - c - coupled calcium - ion release and protein kinase c activity, improvement in the amount of mutated cftr reaching the plasma membrane, and thus restoration of pancreatic anion secretion
Nyd - sp27內源性表達在人體的胰腺導管上皮細胞，並在囊性纖維化時表達增高，顯示該基因可能與病變有關。研究人員發現通過抑制該基因在人體囊性纖維化胰腺導管細胞中的表達，可以糾正缺陷的胰腺陰離子分泌。Researchers at the epithelial cell biology research center of the faculty of medicine, the chinese university of hong kong, and their collaborators from the nanjing medical university have recently cloned a new gene related to pancreatic insufficiency in cystic fibrosis
香港中文大學上皮細胞生物學研究中心與南京醫科大學的合作研究，發現並成功克隆一個與囊性纖維化所致胰腺功能缺陷相關的新基因。Professor chan hsiao chang, director the epithelial cell biology research center explained, " the upregulation of nyd - sp27 in pancreatic - duct cells may reveal a previously unsuspected defect in cystic fibrosis contributing to pancreatic insufficiency, and thus represents a new target for pharmacological intervention in cystic fibrosis.
負責該項研究的香港中文大學生物學研究中心主任陳小章教授指出，該基因在囊性纖維化胰腺的高表達，顯示一種以前未曾為研究人員注意到的導致胰腺功能缺陷的病理機制，而實驗結果提示該基因可能成Eat more fruits, vegetables and whole grai, particularly oats, bea and legume the fiber slows digestion, limiting ikes and dro in blood i ulin and sugar levels
多吃蔬菜、水果和全麥製品，尤其是燕麥、大豆和豆莢；這些食物中的植物纖維可以延緩消化，減少血液中胰島素和血糖水平的巨大起伏。Our understanding of the pathogenesis of cp has improved in recent years, though important advances that have been made with respect to delineating the mechanisms responsible for the development of pancreatic fibrosis ( a constant feature of cp ) following repeated acute attacks of pancreatic necroinflammation ( the necrosis - fibrosis concept )
雖然慢性胰腺炎重要的進展在於闡述反復急性胰腺壞死性炎癥（壞死纖維化觀點）后胰囊性纖維化（慢性胰腺炎的永久特性）的發生機制方面，但最近幾年我們對于慢性胰腺炎發病機理的理解已有所更新。However, the most frequent reason for infants with pancreatic insufficient cf to be diagnosed is failure - to - thrive
然而，嬰兒被診斷為囊腫性纖維化（屬遺傳性胰腺病）的最常見原因是發育不良。分享友人