脾骨髓的 的英文怎麼說
中文拼音 [bìgǔsuǐde]
脾骨髓的
英文
lienomedullary-
Animals lacking ppar - gamma had skeletons with increased bone mass. in addition, the medullary cavity space was decreased and extramedullary hematopoiesis was seen in the spleen
缺乏ppar -的小鼠骨重增加，此外，骨髓腔尺寸減小，脾臟顯示骨髓外造血作用The splenectomy also removes a suppressant of bone marrow platelet production or release.
脾切除術還消除了抑制骨髓生產或釋放血小板的作用。Such massive splenomegaly is usually indicative of some myeloproliferative disease such as chronic myelogenous leukemia or myelofibrosis
這樣的脾腫大通常預示有骨髓增生型疾病，例如慢性髓性白血病或骨髓纖維化。This kind of anaemic characteristic is iron of keep in storage of the lack in organ of marrow, liver, lienal etc, organization, serum iron chroma and serum iron degree of saturation all low, the red blood cell in blood of the loop in typical case presents pigment the expression with low, small cell
這種貧血的特點是骨髓、肝、脾及其他器官、組織中缺乏貯存鐵，血清鐵濃度和血清鐵飽和度均低，在典型的病例中循環血液中的紅細胞呈現色素低、細胞小的表現。In order to understand the mechanism of mtx further and to investigate the genotoxic target organs, we studied the dna damage and the correlation with dose of mtx by using the alkaline single cell gel electrophoresis ( comet ) assay. liver, spleen, bone marrow, thymus, kidney, testicle, stomach and peripheral lymphocytes of mice were isolated at lh, 3h, 6h, 12h, 24h after 5mg / kg mtx intraperitoneal injection
為了進一步了解甲氨蝶呤（ mtx ）的作用機制，探測其作用的遺傳毒性靶器官，為應用mtx治療過程中的臨床監測和副作用防治提供理論依據，我們以小鼠為研究對象，用單細胞凝膠電泳技術檢測了mtx腹腔注射染毒1h 、 3h 、 6h 、 12h 、 24h后對肝、脾、骨髓、胸腺、腎、睪丸、胃和外周血淋巴細胞的dna損傷作用及損傷程度與mtx劑量間的關系。Methods : the balb / c mouse is immunized with gene recombinant antigen p24 for four times in 2 months. the spleen cells of immunized mouse is hybridized with sp2 / 0 by peg, and the positive cell clones secreting the antibody to antigen p24 are detected by indirect elisa. through three clonings less diversed anti - p24 hybridoma cells are gained
方法：基因工程p24抗原免疫小鼠4次，歷時2個月，取脾細胞與骨髓瘤細胞株sp2 0 ，用peg融合， hat選擇培養和間接elisa篩選分泌抗p24抗體陽性的雜交瘤細胞，三次克隆化后得穩定分泌抗p24抗體的雜交瘤細胞株。The results showed that : significant increase in dna migration and comet frequency in the spleen, thymus, bone marrow and peripheral lymphocytes were induced after intraperitoneal treatment of mtx at a dose of 1. 25 ~ 5mg / kg. no obvious increase in dna single strand breaks was observed in the liver, kidney, testicle and stomach of the mice with the same treatment. the migration of nuclear dna and comet frequency of spleen, thymus, bone marrow and peripheral lymphocytes in the dose - response study showed a dose - dependent increase
實驗結果：腹腔注射5mg kgmtx后3h可誘發小鼠體內脾細胞、骨髓細胞、胸腺細胞和外周血淋巴細胞的dna單鏈斷裂且隨時間延長損傷程度增大，於12h達到高峰，但未觀察到對肝、腎、胃和睪丸細胞的山窗民科大學碩士學位論文影響;核dna損傷程度隨著用藥劑量的增大而增大。The results indicate that dna ssbs could be induced by mtx in some cells of mice. there are differences in sensitivity of various organs in the mice and cells of spleen, thymus, bone marrow and peripheral lymphocytes may be the important target cells of mtx
結論: mtx可致小鼠體內多臟器細胞的dna單鏈斷裂，不同臟器細胞對mtx的易感性不同，脾、骨髓、胸腺、外周血淋巴細胞可能是mtx的遺傳毒性靶細胞。分享友人