血吸蟲卵 的英文怎麼說
中文拼音 [xiěxīchóngluǎn]
血吸蟲卵
英文
schistosome ovum-
The mouse model of hepatic egg granuloma of schistosoma japonicum confirmed that np30 has sensitizing effect on formation of hepatic egg granuloma, active immunity in sheeps and mice with np30 can induce good protecti on against infection with schistosoma cercariae and reduces immunopathologic damage to host, np30 plays a significant down - modulatory role to hepatic granuloma and fibrosis
以往的研究業已證明np30對蟲卯肉芽腫的形成具有致敏作用，並有十分顯著抗蟲卵肉芽腫肝纖維化作用，用np30主動免疫小鼠、山羊可減輕日本血吸蟲對宿主造成的免疫病理損害。Yherefore, many researchers have shown great concern with the development of vaccines to against schistosomiasis. at early stage, the research of vaccines of schitosomiasis was centered on dead vaccine and athenuated cercaria of schistosomes while molecular vaccine and athenuated cercaria of schistosomes while molecular vaccine is currently the focus of research with anti - infection protective immunity as its main concern. guan xiaohong and zhao weixian ( 1986 ) certified that the allergen of egg granulonma of schistosoma japonicum might firstly come from gut associated antigen ( gaa ) of schistosomula and adult worm and that daa had cross reaction with soluble egg antigen ( sea ) and membrane associated antigen ( maa ) ; and the gaa of schistosoma japonicum might play a sensitizing role in egg granuloma formation
Np30主動免疫c57bl 6對尾蚴攻擊感染產生42 . 05的保護力，肝組織減卵率為66 . 63 ； balb c和昆明種小鼠的保護率分別為39 . 53和50 . 46 ；免疫山羊可誘導42 . 78的減蟲率，肝組織減卵率為35 . 83 ，糞減卵率為25 ，並可明顯抑制肝臟蟲卵肉芽腫的大小，肉芽腫數量明顯減少，纖維化減輕，體重明顯增加，因此np30是南京醫科大學博士學位論文很有希望的抗日本血吸蟲病疫苗侯選分子。Guan et al ( 1991 ) established a strain of monoclonal anti - idiotypic antibody np30 ofschistosomajaponicum, which is an internal image anti - idiotypic antibody of gut associated antigen ( gaa ), its antibody isotype is igm. np30 has a partial cross reaction with soluble egg antigen ( sea ) and membrane associated antigen ( maa ). np30 molecule has been researched on many aspects
管曉虹等（ 1991 ）建立了一株日本血吸蟲單克隆抗獨特型抗體np30 ，已證實為腸相關抗原（ gaa ）的內影像抗獨特型抗體，其抗體同型為igm ，與可溶性蟲卵抗原（ sea ）及膜相關抗原（ maa ）有部分交叉反應。Guan xiaohong, et al. ( 1991 ) established a strain of monoclonal anti - idiotypic antibody np30 of schistosoma japonicum, whice is an internal image antigen of gut associated antigen ( gaa ), its antibody isotype is igm. np30 has a partial cross - reaction with soluble egg antigen ( sba ) and membrane associated antigen ( maa )
管曉虹等建立的日本血吸蟲單克隆抗獨特型抗體（ anti - id ， ab _ 2 ） np30是腸相關抗原（ gaa ）的內影像anti - id ，與可溶性蟲卵抗原（ sea ）有交叉反應，可替代蟲源性抗原用於血吸蟲病免疫診斷和抗病疫苗的研究。It has been confirmed that np30 has sensitizing effect on formation of hepatic egg granulomas in mouse model for hepatic egg granuloma of schistosoma japonicum ; immunization with np30 in kunming mice, c57bl / 6 mice and goats obtained worm reduction of 50. 46 %, 41. 67 % and 42. 78 %, respectively. np30 possesses effects of both anti - fecundity and anti - embryonation immunity on female worms of s. japonicum. moreover, np30 plays a significant down - modulatory role to hepatic granuloma and fibrosis ( the diameter, area and volume of egg granuloma were all significantly less than those of control ; the contents of type i, iii of collagen and fibronectin were also significantly less than those of control )
已對np30分子進行了較為廣泛的研究，應用小鼠日本血吸蟲肝肉芽腫模型證實np30對蟲卵肉芽腫的形成具有致敏作用；對感染宿主（昆明種小鼠、 c57bl / 6小鼠和山羊）具有較好的免疫保護作用（減蟲率分別為50 . 46 、 41 . 67和42 . 78 ） ；用np30主動免疫小鼠具有抗雌蟲生殖產卵和抗卵胚發育的雙重功效；另外，還對血吸蟲病肉芽腫和肝纖維化有明顯的負調節作用（蟲卵肉芽腫的直徑、面積和體積均明顯小於對照組，肝組織、型膠原及纖維連接蛋白含量均低於對照組） 。Schistosomiasis is a serious threat to the public health worldwide. egg granuloma formation and subsequently hepatic fibrosis are the main pathological basis of schistosomiasis japonica
血吸蟲蟲卵引起的肉芽腫以及隨之發生的纖維化是血吸蟲病的主要病理基礎。分享友人