隆達族 的英文怎麼說
中文拼音 [lōngdázú]
隆達族
英文
lundas-quiocos-
It is interesting that pma plus calcium ionophore a23187 can inhibit pma - induced pta1 expression, and this effect ca n ' t be reversed by calcmeurin inhibiter fk506. pta1 mabs can inhibit ctl activation and differentiation in mixed lymphocyte culture system when added at the beginning of the culture but can induce platelet activation and aggregation in the fc dependent manner. in 1997, pta1 cdna was cloned from cdna library of tpa activated jurkat cells, which belongs to immunoglobulin superfamily ( igsf ) with two v - like domains of extracelluar region of pta1
Il - 2 、 tnf - 、 pma可以使t細胞pta1表達上調， tgf -可以下調pta1的表達，而pma加上鈣離子載體a23187可以顯著抑制pma的上調作用，且這種抑制作用不被calcineurin抑制劑fk506所逆轉， 1997年burns教授從pma活化的jurkat細胞cdna文庫中克隆了pta1cdna全長，證實pta1是一個新分子，屬于免疫球蛋白超家族，胞膜外區有兩個v樣結構域。In this paper, phylogenetic relationship of 13 species involved in 6 genera of cruciferae wer e carried out through both the clones of homologous sequences with the primers designed on the basis of conserved regions of cyp86mf gene in cytochrome p450 gene superfamily and the differential analyses of them. meanwhile, complete sequences of some genes in cytochrome p450 gene superfamily were isolated and identified by smart pcr - race strategy, and expressed in e. colt. the results were as follows : ( 1 ) isolated by pcr from 11 species of cruciferae, eleven homologous gene segments that deduced amino acids were identities of over 80 % at nucleotide sequence level and similarities of over 70 % at amino acid sequence level
本論文以已知的細胞色素p450基因超家族成員cyp86mf基因的保守區設計引物對十字花科重要蔬菜作物的6個屬13個物種進行了同源序列的分離克隆，通過核酸序列的差異比較分析，研究了該基因在不同物種中的進化關系；同時，通過保守引物的pcr擴增和race相結合的方法對十字花科植物不同物種的細胞色素p450基因家族成員基因全長進行了分離克隆、鑒定和原核表達的研究，獲得如下研究結果： （ 1 ）通過pcr從十字花科植物不同物種中擴增到11個可以推導出完整氨基酸序列的同源片段。Although the gene therapy of the human nerve system diseases are still in exploring so far, and similar studies applied to the wild animals have not even been reported, this study will inevitably provide clues for futher studies on the gene therapy in the giant panda and crested ibis
目前，雖然對人之癲痛與視神經病變類疾病的基因治療尚處于探索階段，而動物在此領域的工作尚未起步，但本文所完成的大熊貓和朱鶴神經營養因子（ ntfs ）基因家族的克隆、表達及活性鑒定工作，無疑為后續的深入研究奠定了基礎。In addition, some ntfs could induce the development of normal vision pathway, and even help the injured neuron to regenerate synapse. in this study, the genes coding for mature nts and gdnf were cloned through polymerase chain reaction. after sequencing, alignment showed the ntfs were highly conserved
研究表明，神經營養因子對癲癇造成的神經元損傷具有保護及再生作用，而對于視神經通路的發育和分化，以及受損視覺通路的修復也饒剛：大熊獨和朱賜神經營養因子基因家族的克隆、表達及活性鑒定起到關鍵作用。These results suggest that kyot plays an important role in the development of testis and spermatogenesis. 2 we performed yeast two - hybrid screening of a cdna library from human lymph nodes using kyot2 as a bait protein. 42 clones were gotten after 5xl06 were screened by four kinds of nutrition limitation and p - galactosidase assay, 22 clones were got after restriction of positive clones, at last, 13 genes were got by sequence assay including rbp - j known as the interacting protein with kyot before and two novel genes
對此22個克隆進行序列分析，共獲得13種基因，其中包括已知的kyot相互作用蛋白rbpj和兩個未知基因，也包括在哺乳動物睪丸中特異3第四軍醫大學博士學位論文性表達的蛋白piasi ，同時還篩到了具有可與lm結構鞠互作用的pdzdomain分子緊密連接蛋白2和兩種同屬于kg家族的蛋白ringi和polycomb2In 2001, wilson and his colleagues cloned another two members - human wnk1 gene and wnk4 gene which were located on chromosome 12 and 17, respectively. the two genes are disease - causing genes responsible for a mendelian hypertension. the disease - causing mutations are the large deletions in the first intron in wnk1 gene, causing increased expression in leukocytes
2001年， wilson等克隆了此家族的另兩個成員? ?人的wnk1和wnk4基因，分別位於12號和17號染色體，這兩個基因是一種孟德爾遺傳型高血壓病的致病基因，致病突變分別是wnk1基因第一內含子的大片段缺失，導致患者白細胞的基因表達量提高5倍左右。分享友人