autophosphorylation 中文意思是什麼
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Gfral is an extracellular protein that is attached to the outer cell membrane by gpi - anchor and could not transducted signalling directly. according to the original model, a gdnf dimer first binds to either monomeric or dimeric gfral, and the gdnf - gfral complex then interacts with two ret molecules, thereby inducing their homodimerization and tyrosine autophosphorylation
傳統觀點認為： gdnf首先與gfr 1結合形成gdnf - gfr 1復合物，此復合物再與ret結合形成三聚體復合物，引起ret的二聚化，並引起酪氨酸殘基自磷酸化，從而引起下游的信號轉導。 -
Nh2 terminus lacks a " destruction box " that controls the ubiquitin - dependent degration but contains an epithdermal growth factor receptor - like autophosphorylation sequence in addition to cyclin box. the structure hints that it is not only a cyclin in cell cycle regulation but also an intracelluar signal transducer molecule. cycg has not yet been matched with a cdk binding partner, and it ' s biologic function is still elusive
G型蛋白是細胞周期蛋白家族中的新成員，它的分子結構與多數cyclin有所不同，其n端缺少降解所需的「 destructionbox 」氨基酸序列，而c末端卻包含有與表皮生長因子受體相似的自主磷酸化位點，這些表明它既是一種細胞周期蛋白，也是細胞內的信號傳導分子。
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