elongator 中文意思是什麼
elongator
解釋
伸出臂-
The rnapii - associated complex elongator has histone acetyltransferase ( hat ) activity and thus might fulfil such a role
與磷酸化的rnap結合的elongator復合物具有組蛋白乙酰轉移酶（ hat ）活性，它可能執行這一功能。 -
Yeast elongator was isolated as a complex that associates with the chromatin fraction and interacts with the elongating phosphorylated form of rnap ii. the functional entity of elongator complex has recently been shown to be an unstable six - subunit complex, termed holo - elongator, which can dissociate into two discrete three - subunit subcomplexes upon treatment with high salt and / or monoq chromatography. one of these subcompexes is the elp3 - containing core complex, and the other is a complex of the elp4, elp5 and elp6 proteins
酵母elongator是與染色質組分結合，並與延伸中的磷酸化形式的rnap相互作用的復合物，是個六亞基的功能整體，在高鹽處理或monoq層析時易於分解為兩個三亞基亞復合物，其中一個是含elp3的核心復合物，另一個含elp4 5 6亞基。 -
Mutations that debilitate the hat activity of eip3 in vitro also confer elp phenotypes in vivo, indicating that the hat activity of elongator is required for its function
Elp3具有hat活性，該活性為復合物行使功能所必需。使elp3的hat活性嚴重喪失的點突變可引起所有elp表型。 -
Recently, human elongator complexes have been isolated. the human complex is a fragile six - subunit complex that interacts with rnap ii and has hat activity directed against histone h3 and h4. depletion of elongator from hela nuclear extracts reduces the ability of these extracts to transcribe chromatin templates, providing biochemical support for the proposed role of elongator during transcript elongation in chromatin
近來人elongator也被分離，它也是個不穩定的六亞基復合物，可與rnap相互作用，具有hat活性，能乙酰化h3和h4 ，在hela細胞核抽提物中去除elongator可降低抽提物對染色質模板的轉錄延伸速率，提供了該復合物在染色質為模板的轉錄延伸中有功能的生化證據，但是上面的信息都來自體外研究。 -
Human elongator complex serves a role in chromatin remodeling through modifying the lysine residues of histone h3 and h4 during transcription elongation in higher cells. the main results and conclusions are as followings. 1 using depletion strain of yeast as material, we have established a system for complementation test and gene expression analysis of human elongator complex
4 、利用點突變和plasmidshuffle等技術構建了含h3k14一r 、 h4ks ~ r單突變和h3k14一側h4ks一r雙突變的e1p3乙菌株，通過功能互補實驗分析少凡p3對突變株的補償功能，證實酵母elongator可對h314k / h4sk進行乙酞化修飾。 -
The activity of intact elongator complex is directed specifically toward the amino - terminal tails of histone h3 and h4, the predominant acetylation sites are lysine - 14 of histone h3 and lysine - 8 of histone h4
完整的復合物可直接修飾組蛋白h3和h4尾部，其優先乙酰化位點是h3k14和h4k8 。 -
There have been no reports so far on the characterization of human elongator complex in vivo. in this thesis, we studied the function of hat activity of human elongator complex in gene expression and regulation in saccharomyces cerevisiae
證明了人與酵母的elp3在功能上是保守的，初步確定了help3及其擁有的hat活性在復合物中的功能地位，了解了復合物hat活性在基因表達調控中的作用方式。
分享友人