genetic lethal 中文意思是什麼
genetic lethal
解釋
遺傳致死-
Alterations in glycosylation have been proposed to participate in cell adhesion, receptor activation, cell differentiation and tissue morphogenesis. because the early embryo is composed of cells that must adhere to other embryonic cells, it seems likely that glycans modulating this adhesion would have been indispensable for early development. genetic elimination or partial abrogation of expression of some major classes of glycans, such as n - glycans, glycosphingolipids, hyaluronan and sialic acids, has been shown to be lethal during murine embryogenesis
胚胎發育過程中伴隨著細胞表面糖鏈表達水平及結構的改變，研究表明這些改變參與介導了胚胎細胞之間的粘附聯系，因此，糖鏈對于胚胎正常發育是必須的，一些糖鏈結構（如n -連接糖鏈，糖鞘脂，透明質酸，唾液酸等）的表達缺失能導致小鼠死亡于胚胎的早期發育階段。
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