gtpase activating protein 中文意思是什麼
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Rab7 mediates transport of proteins from early endosome to late endosome or fusion of early endosome with late endosome, while rab9 mediates the retransport of m6pr from late endosome to trans - golgi network. the gtp / gdp - binding ability and intrinsic gtpase activity of rab proteins make them exist in rab - gtp or rab - gdp status. the switching of rabs between gtp - bound ( active ) and gdp - bound ( inactive ) forms requires other regulatory proteins, including guanosine exchange factor ( gef ), gdp dissociation inhibitor ( gdi ) and gtpase activating protein ( gap ), and lays the foundations of rab function
Rab蛋白家族成員和其他小g蛋白一樣可以結合gtp gdp ，在自身gtp酶的水解作用和其他蛋白（ gef 、 gap 、 gdi ）的調節作用下發生gtp （活化狀態）和gdp （無活性）結合形式的轉變；同時rab蛋白也在膜結合性（ membrane - bound ）和胞漿可溶性（ cytosolic ）之間變化，一個變化過程對應著一個功能循環，接著rab蛋白回到初始狀態參與下一個循環。
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