kipl 中文意思是什麼
kipl
解釋
基普爾-
The protein level of p21 increased lightly from 1 to3 h, then decreased at 6 - 9 h, reached maximum at 24 h after 2gy, it increased from 3 to 24 h exposed tology, and the protein level of p21 associated with cdk2 increased, which did not inhibit the cyclin e / cdk2 kinase activity, because of upregulation of cyclin e and deregulation of p27kipl after irradiation. in contrast to p21, p27kipl may be a key regulator of cyclin e / cdk2 activity in dna damage responses. hi the ubiquitin - proteasome pathway invovled in regulation of p27kiplexpression in response to ir the ubiquitin - proteasome pathway regulated selective and time - controlled elimination of p27 kipl
與p27ki 」 ，表達水平不同， pzi蛋白表達水平在zgy照射后略有增加， 6一gh略有下降，在照后24h達到最大; 10gy照后1一3h開始增加，持續到24h ，並且cycline / cdkz復合物中pzi蛋白結合增多，但cycline / cdkz激酶活性並未受到抑制，除了因ir誘導cydine蛋白表達水平增加外，另一重要的原因就是與pzi同一家族的p27kip ，蛋白表達水平下降，失去了對cycline / cdkz的抑制活性。
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