protein kinase b 中文意思是什麼

protein kinase b 解釋
蛋白質激酶
  1. Protein kinase b ( pkb, also named kinase akt ) is newly found as a ser - ine / threonine protein kinase

    Pkb akt2在卵巢癌、胰腺癌細胞中過表達， pkb akt3在大腦和睪丸中表達。
  2. Huangyal4 was complete nucleotide sequence of 1 854 bp with a nucleotide orf ( 1575 bp ), which encoded a protein consisting of 524 aa with molecular weight of 62. 2 kda and pi of 8. 96. strongly basic ( + ) amino acids, strongly acidic ( - ) amino acids, hydrophobic amino acids and polar amino acids of the protein were 13. 74 %, 11. 64 %, 36. 45 % and 22. 70 % respectively, and predicted secondary structure of the protein revealed many conserved domains such as n - glycosylation site, protein kinase c phosphorylation site, casein kinase ii phosphorylation site, n - myristoylation site, camp - and cgmp - dependent protein kinase phosphorylation site, tyrosine kinase phosphorylation site and a cytochrome p450 cysteine heme - iron ligand signature which was typical of cytochrome p450. a - helix and b - sheet of the protein is 47. 7 %, 45. 0 % respectively

    Huangya14 ）為材料分離克隆到一個細胞色素p450基因，命名為bccyp86mf5 ， cdna全長1854bp ，含1575bp的完整開放閱讀框，編碼524個氨基酸，其編碼蛋白質的分子量為61 . 2kda 、等電點為8 . 96 ；堿性氨基酸、酸性氨基酸、疏水氨基酸和極性氨基酸分別占總氨基酸的13 . 74 、 11 . 64 、 36 . 45和22 . 70 ；二級結構預測包括n -糖基化位點、依賴于camp和cgmp的蛋白激酶磷酸化位點、蛋白激酶c磷酸化位點、酪蛋白激酶磷酸化位點、酪氨基酸激酶磷酸化位點、 n -豆蔻酰化位點和細胞色素p450的典型區域，半胱氨酸亞鐵血紅素配體信號區等， -螺旋和-折疊分別佔47 . 7 、 45 . 0 ；與bccyp86mf1基因的氨基酸序列同源性達到95 . 2 ，與擬南芥cyp86c4的達到85 . 9 。
  3. Mpf is a complex that consists of the protein kinase p34cdc2 and the regulatory protein cycli b ; the protein kinase activity of p34cdc2 is strictly dependent on its association with cyclinb. in xenopus laevis eggs the absent of cyclin b, mpf will not be activited

    Ca卜活化p34 」擬的機制第一步是結合cycinb ，並且處于磷酸化狀態，即thr14 、 tyrls和tlirl61都處于磷酸化狀態；第二步是cdc25磷酸酶通過是thr14 、 tyr15脫磷酸化而激活p34 」擬。
  4. 15 heinrich r, neel b g, rapoport t a. mathematical models of protein kinase signal transduction. mol. cell, 2002, 9 : 957 - 970

    這些結果有助於設計相關的生物實驗，進一步研究細胞的jak - stat信號通路的對外界影響的變化。
  5. This article briefly reviews the regulative effects of these signaling pathways including protein kinase c, mitogen activated protein kinase, and phosphoinositide 3 ' - oh kinase / protein kinase b

    本文簡要介紹心肌細胞內皮素激活蛋白激酶c 、絲裂原激活蛋白激酶、磷酸肌醇3 '羥基激酶蛋白激酶b等信號通路的調節作用。
  6. Protein kinase b is newly found as a serine / threonine protein kinase, it could have widely spread functions in cell cycle regulation. the activation of protein kinase b / akt is thought to be a critical step in the phosphoinositide 3 - kinase pathway which regulates cell growth and differentiation

    蛋白激酶c （ proteinkinasec ， pkc ）和蛋白激酶b （ proteinkinaseb ， pkb ）同屬于絲蘇氨酸蛋白激酶，廣泛參與細胞的多種生命過程，包括生長、分化、細胞周期調控、細胞凋亡等。
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