restin 中文意思是什麼
restin
解釋
雷斯廷-
The tumor cells transfected with restin are arrested in gl phase and the cell proliferation is inhibited. it implies that restin may be correlated to cell cycle regulation. other data showed that the necdin, a homolog of restin, could suppress cell growth by interacting with transcription factor e2f1 and p53
而與restin的同源蛋白的necdin ，可以與細胞周期促進蛋白sv40大t抗原、腺病毒eia 、轉錄因子ezfi等相互作用，抑制細胞生長;也可以和轉錄因子p53作用參與生長抑制和抑制p53誘導的細胞凋亡。 -
The results showed that all six tfs displayed no autoluminescence in this two - hybrid system, and one of them, the atf3 displayed a strong interaction with restin. to verify the interaction of restin and atf3, a series of truncated fragments of atf3 were inserted into pact to be used in the further study
三、為了進一步驗證atf3與restin的相互作用，對atf3進行截斷並構建了一系列atf3的截短片段的雙雜交質粒（仍然構建於pact載體中） ，再次運用細胞雙雜交進行相互作用的探索。 -
Chomez and colleague also found this gene by homologous sequence splicing in the database of gene bank in 2001 and named as mage - hi, but there are no any biological functions of restin reported
2001年， chomez等通過同源序列篩選genbank數據庫，也發現了該基因，並命名為mage - h1 ，但有關該基因的具體生物學功能研究還沒有報道。 -
Restin was a novel gene isolated by our lab from differentiation tumor cell induced by all - trans retinoic acid in 1999, and its molecular functions were not well understood. it mainly expresses in terminally differentiated cells. by transfection of restin into tumor cell, the cells were arrested in g1 phase and the cell proliferation was inhibited
Restin是1999年本室在研究全反式維甲酸誘導細胞分化時克隆得到的一個人類未知功能的新基因，該基因主要表達于終末分化細胞，穩定轉染該基因的細胞出現g1期阻滯，抑制細胞的增殖，提示restin與細胞周期的調控有關。 -
The phylogenetic analysis of mage family proteins and restin shows that the relationship of restin is nearer to type ii, such as mage - d1 and necdin, rather than type i mage members
進一步的分析發現， restin定位於xp11 . 22 ，開放讀框全部位於一個外顯子中，這同絕大多數mage基因的定位特點及基因組結構一致。 -
And a atf3 - bd reduced the activity of interaction with restin. it suggested that restin most likely interacted with atf3 binding domai
激活的atf3可以通過jnk / sapk信號傳遞途徑抑制細胞內部分基因的轉錄和細胞的增殖。 -
The tissue expression analysis of restin shows that restin same as necdin and mage - d, is high expressed in prostate, testis, nervous tissue and fetal tissues, and low or less in the white blood cells and tumor tissues
而在腫瘤組織中不表達或表達量極低，這與h類mage家族成員mage一d 、 necdin表達分佈規律相一致。 -
A lot of transcription factors such as atf, c - fos, c - jun, e2f and p53 were envolved in this stage. in this study, we try to identify the transcription factors interacted with restin by using mammalian cell two - hybrid system
當細胞自靜止狀態的go期進入gi期時，眾多轉錄因子如燈f 、 e一fos 、 e一jun 、 ezf 、 p53等均參與這一進程。 -
Morever, tcherpakov and colleague found that the mage - d1, necdin and mage - hi ( restin ) could interacted with p75. so, we deduced that the restin most likely regulated cell cycle by interacting with some transcription factors
Restin與necdin同源性最高，組織表達一致且都具有細胞生長抑制作用， teherpakov等也發現mage家族分子mage一nl 、 needin和mage一hx （ restin ）都可以和p75相作用。
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