transcription repressor 中文意思是什麼
transcription repressor
解釋
轉錄阻抑物,轉錄阻抑蛋白- transcription : n 謄寫，抄寫；轉錄；抄本，繕本，副本；轉寫，翻譯；【音樂】樂曲改作；【無線電】錄音；錄音廣播；（...
- repressor : 壓抑劑
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To search proteins that associate with the mouse mint protein and regulate notch signaling in nuclei, and to study the function and mechanism of mint - mediated transcription repression, yeast two - hybrid assay was used to screen proteins that interact with a fragment of mint ( f5, amino acids 2226 - 2959 ). from 4x106 yeast clones transformed with the bait plasmid and a cdna library of 9 dpc mouse embryo, fifty - one were positive for nutritional screening and p - galactosidase assay. restriction digestion identified 10 independent positive clones and these were analyzed by dna sequencing these clones represent 3 correctly fused cdna fragments, which are mint, alpha a - crystallin - binding protein i ( alphaa - crybpl ), and nuclear receptor co - repressor 1 ( n - corl ), respectively
鑒于mwt基因編碼區較長，共有10799個堿基，故此我們將mint分為六段，分別命名為fi一f6 ，本研究以其中的f5 （ 222e959 ）和f6 （ 296s576 ）片段為研究對象，將h者分別插入pgb盯7載體中，結果顯示： mintfs可與核受體輔助抑制因子1階cori ） ， o晶狀體蛋白結合蛋白1hlphatcrybp入及mw加互作用，而f6可與igm的重鏈恆定區、泛素結合酶2l6和一個未知功能的新的蛋白基因進行結合。 -
Aes contains a glutamine - rich ( q ) domain in its n - terminal, which sharing high homology with the amino terminal region of groucho / tle ( transducin like enhancer of split ). the function of aes is not clear yet, while groucho / tle were found to be a family of transcription co - repressor and play impo rtant roles in notch signaling, wnt - 0 catenin signaling and other transcription regulation events
Aes的n -末端約130個氨基酸中富含谷氨酰眩（ q ）殘基，形成一個q結構域，與轉錄協同抑制分子tle （ transducinlikeenhancerofsplit ）的氨基端高度同源。
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