拓撲異構酶 的英文怎麼說
中文拼音 [tàpūyìgòu]
拓撲異構酶
英文
dna topoisomerases: recq helicase systemsdna-
In the laboratory experiment part, human peripheral blood, cultured cells and icr mice were study objects. the changes of mitotic chromosome numbers were measured by human metaphase chromosome counts and statistic analyzed used x2 - test. the changes of meiotic chromosome numbers were measured by mice one - cell zygote chromosome counts and statistic analyzed usedx2 - test. the effects of low dose ionizing radiation on the expression of topoisomerase ii were measured by immunocytochemistry, western blot and rt - pcr
流行病學結果顯示長期小劑量輻射接觸與染色體不分離呈正相關，為進一步在細胞遺傳學和分子生物學方面研究小劑量電離輻射與染色體不分離關系及其機制，本課題第二部分以外周血、培養細胞、 icr小鼠為研究對象，用外周血染色體計數和單細胞受精卵染色體計數的方法研究小劑量輻射和拓撲異構酶復旦大學2000級博士生學位論文11a抑制劑及其二者的協同效應對有絲分裂和減數分裂染色體不分離的影響，用免疫細胞化學染色、 westernblot 、 rt pcr等方法研究了電離輻射引起拓撲異構酶a表達變化。The expression of topoisomerase ii of cultured cells treated low dose ionizing radiation decreased and then returned as time went. and become outstanding as radiation dose and frequency were added. inhibitor of topoisomerase ii could cause chromosome non - dis juction in mitosis and meiosis. and the co - effect of inhibitor of topoisomerase ii and ion
05 ） ，具有隨照射次數增加而增加的趨勢；小劑量電離輻射可以引起拓撲異構酶a表達變化，隨照射后時間延長先下降后回升，隨照射劑量和次數的增加，變化更加明顯；拓撲異構酶11a抑制劑可引起有絲分裂和減數分裂時染色體的不分離；拓撲異構酶a抑制劑和電高輻射的協同作用使染色體不分離更加明顯。The orf1 proteins of all four chinese senv isolates had two motifs ( ftl and yxxk ) which were conserved in replication - associated proteins. in all four chinese senv isolates, the putative non - structure orf2 protein had a cav - like region. the putative orf3 protein had a serine - rich tract preceded by a cluster of basic amino acids ( r and k ). database scaning suggested this region had high a percentage of homology with dna topoisomerase i protein of d. melanogaster, and might play an important role in the replication of such single - stranded dna viruses
所有這四個中國分離株，均保留了o即1中與復制有關的保守序列（ ftl和yxxk ） :在推測是非結構蛋白的orfz中均含有cav樣保守區w 『 x7一h一x3一c一xl一c一xs一h ; orf3蛋白的堿性氨基酸（精氨酸和賴氨酸）簇后緊接著一個富含絲氨酸的區域，與d . molanogaster的dna拓撲異構酶i有一定的同源性，推測在單鏈dna的復制中起作用。
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