核噬作用 的英文怎麼說
中文拼音 [héshìzuòyòng]
核噬作用
英文
phagokaryosis-
Translocation from endocytic compartments to the cytosol is the essential and rate - limiting step in the intoxication process of most toxins such as ricin, diphtheria toxin, shiga toxin and pseudomonas exotoxin ( pe ). a number of these toxins are transported to trans - golgi network ( tgn ), and in many cases such transport to the tgn is required for the translocation and cytotoxicity. in deed, 5 % of the ricin endocytosed by cells has been shown to reach the tgn
蓖麻毒素進入細胞的機理不甚明了,一般認為是rtb先與細胞膜受體結合,主要經過受體介導的內吞作用進入吞噬體,然後沿著內體、高爾基體、內質網等逆向分泌途徑,有序地運輸到內質網,最後從內質網轉位進入細胞漿,在胞漿內攻擊核糖體,從而抑制蛋白質的合成,導致細胞死亡。The phagosome is the organelle responsible for the destruction of infectious pathogens that cause such diseases as tuberculosis and salmonellosis, as well as pathogens that could be used in bioterrorism
吞噬小體是一種細胞器,其功能是消滅侵入人體的傳染性病原體,這些病原體能夠引起諸如結核病和沙門氏菌病等,故能夠被用作生物恐怖行動。They can induce the immunocytes to secret numbers of immune - functional molecules, which mediate the stimulation of the whole immune system. there is difference that whether chitin and its derivatives alone can induce macrophages to produce nitric oxide ( no ) and tumor necrosis factor ( tnf ). the data gained from giuseppe balsamo et al
但對於它們在免疫系統中某一特定環節的作用仍存在分歧,比如殼聚糖、殼寡糖單獨作用於單核巨噬細胞能否誘導其分泌一氧化氮( no ) 、腫瘤壞死因子( tnf )等細胞因子。There are still many questions remain unanswered, including the mechanisms that specify oligochitosan recognition, the participation of additional molecules in transmembrane signaling, and the repertoire of downstream pathways activated by oligochitosan. it was also observed that pdtc did not totally block no production, which gave us another evidence that there must be some other signal transduction pathways ( perhaps mapk, pkc, ca2 + dependent signaling ) involved in the activation, so further investigation is necessary to clarify molecular mechanism of oligochitosan inducing immunological en
Westemblot結果顯示100林歲ml劑量的殼寡糖作用於raw264 . 7細胞( 4x105個細胞/ ml ) 4h ,胞核內p65的含量明顯增加, 6h時達到高峰, 10h時恢復到基礎表達量,這就提示在殼寡糖對巨噬細胞的激活過程中nf一kb活化狀態可以持續6個小時。The cells were then stimulated with various concentrations and incubation times of oligochitosan to study dose - dependent and time - dependent manners. the effect of oligochitosan on the production of no released by raw264. 7 cells was evaluated by griess method, which was also used to evaluate the effect of nf - kb inhibitor on no production induced by oligochitosan. western blot was performed to detect the protein content of nf - k b in the nuclear extract
本課題以小鼠單核/巨噬}炎魏細胞raw264 . 7為研究對象,觀察殼寡糖單獨作用於巨噬細胞對其產生no的影響,並初步探討了核轉錄因子一kappab ( nf一kb )在這過程中的作用,旨在部分解釋殼寡糖對免疫系統調節作用的機理,為其在醫學上的應用提供理論依據。Cd 14 * monocytes or bone marrow derived hematopoietic progenitor cells cultured with granulocyte - macrophage colony - stimulating factor ( gm - csf ) and il - 4 differentiate into efficient apc with morphology and cell surface molecule expression typical of immature dc. it was demonstrated that a variety of factors ( such as lps, tnf - a, il - 1, monocyte - conditioned medium, and cd40 receptor cross - linking ) induce the maturation of immature dc to mature dc that are much more potent in activating t cells by increasing the expression of costimulatory molecules and cytokines, promoting the migration of dc to draining lymph nodes, and down - regulating the capacity of dc to capture and process antigen
在體外,外周血cd14 ~ +單核細胞和cd34 ~ +骨髓造血前體細胞在粒細胞-巨噬細胞集落刺激因子( granulocyte - macrophagecolony - stimulatingfactor , gm - csf )和il - 4的共同作用下可分化為未成熟dc ,未成熟dc具有強大的攝取和處理抗原的能力,但其抗原提呈能力較弱;未成熟dc在炎性細胞因浙江大竿俗士學位論文潛廷平子汐ilq , yfax病原成分汐lpsx單核細胞條件培養液或cd40l等作用下可分化為成熟dc 。分享友人