細胞免疫應答 的英文怎麼說
中文拼音 [xìbāomiǎnyìyīngdā]
細胞免疫應答
英文
cell-mediated immune response- 細 : 形容詞1 (條狀物橫剖面小) thin; slender 2 (顆粒小) in small particles; fine 3 (音量小) thin ...
- 胞 : Ⅰ名詞1 (胞衣) afterbirth2 (同一個國家或民族的人) fellow countryman; compatriot Ⅱ形容詞(同胞...
- 免 : Ⅰ動詞1 (去掉;除掉) dismiss; relieve; remove 2 (避免) avoid; escape; avert 3 (免去) excuse s...
- 疫 : 名詞(瘟疫) epidemic disease; pestilence
- 應 : 應動詞1 (回答) answer; respond to; echo 2 (滿足要求) comply with; grant 3 (順應; 適應) suit...
- 答 : 答構詞成分。
- 細胞 : cell; sytes; bioplast; cella; [口語] gene; [生物學] cellule; cellule cellulli cellulo ; cello ; k...
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Dendritic cells are characterized by their ability to efficiently present antigen, and are uniquely equipped to stimulate naive t cell responses. immature dendritic cells acquire antigens from throughout the peripheral body, then migrate to t - lymphocyte - dependent areas of lymph nodes. thus, dendritic cells act as bridges, operating at the interface of innate and acquired immunity
作為機體免疫系統中功能最強的專職性抗原提呈細胞( antigen - presentingcells , apc ) ,樹突狀細胞( dendriticcells , dc )能高效地攝取、加工處理和提呈抗原,具有較強的遷移能力,並能顯著地激活初始型t細胞以啟動t細胞免疫應答反應,此外, dc與b細胞以及nk細胞等也存在著相互作用,可見, dc在連接天然免疫和獲得性免疫之間起著非常重要的作用。It has been demonstrated that complement activating and cr2 cross - linking on b lymphocytes set up a bridge between innate and acquired immunity. the interaction of c3 and cd21 on b lymphocytes will benefit initiating immune response and regulating primary antibody response. cd21 / cd35 is important in the process of antibody avidity maturing, this is critical to b lymphocyte activation especially in the state of low antigen concentration
現己證實補體的活化以及b細胞表面crz的交聯在先天和獲得性免疫之間架起了重要的橋梁,表現為c3與b細胞cdzi的相互作用有利於啟動抗體應答反應,並對初級抗體應答反應有調節作用: cdzi cd35對于抗體的親和性成熟具有重要作用,在抗原濃度低的情況下,對于活化b細胞是至關重要的,而且mlgm (交聯有利於特異的低親和性b細胞對t細胞依賴性抗原和t細胞非依賴性抗原產生免疫應答。Responses to exercise of red blood cell immune adherence
紅細胞免疫粘附對運動的應答Interferon is human body gets virus or double stranded the exciting generation immunity of rna exciter is respondent, by the cell synthesis reachs excretive gens protein kind
干擾素是人體受到病毒或雙股rna刺激物的刺激產生免疫應答,由細胞合成及分泌的一族蛋白質類。Studies on healthy crowd ' s humoral immune responses to purified vero cell rabies vaccine
細胞狂犬病疫苗的體液免疫應答Myeloid dendritic cells, which contribute to an immunologic synapse responsible for activation of the adaptive immune system, are abundant within muscle in inclusion body myositis and polymyositis
作用於免疫突觸反應、活化適應性免疫應答的髓樣樹突狀細胞在包涵體肌炎和多發性肌炎中大量存在。The evidence for a significant role for cell-mediated immune responses in other protozoon diseases of animal is less complete.
在動物的其它原蟲性疾病中,有關細胞免疫應答的重要作用的證據尚不充足。Containing many t cell epi - positions and neutralizing antibody epi - positions, the core protein region and envelope protein 2 of hepatitis c virus ( hcv ) structural protein may induce protective immunity responsion in body
丙型肝炎病毒( hepatitiscvirus , hcv )結構蛋白的核心蛋白( c )和包膜蛋白2 ( e2 )含有多個t細胞表位和中和抗體表位,可誘導機體產生保護性免疫應答。Cell immune response induced by hepatitis b virus dna vaccine in mice
乙肝病毒核酸疫苗誘導小鼠細胞免疫應答的研究Study on the cellular immune responses induced by p30 dna vaccine of toxoplasma gondii in mice
疫苗免疫小鼠誘導細胞免疫應答的研究Salmonella typhimuriwn, one of the invasive bacterial species, can be attenuated without loss of invasiveness and thus used for delivery of eukaryotic expression vectors into host cells in vivo. the recombinant plasmid containing the target gene is released inside the host cells and gain entry into the nucleus, resulting in expression of encoded antigens and subsequent induction of humoral and cellular immune responses
沙門氏菌( salmonellatyphimurium )是一種較為常見的侵襲性胞內菌,通過基因工程方法減毒后對宿主致病性顯著降低,但仍保留良好的侵襲力,可直接將真核表達質粒攜帶進入動物細胞內表達相應的蛋白而誘導特異性的免疫應答反應。Dendritic cells ( dc ) is the most powerful apc, which can markedly increase the antigen - presentation capacity by maximizing the pepitide - mhc complexes on the cell surface and upregulating the co - stimulatory ligands b7 - 1 and b7 - 2, adhesion moleculees such as il - 12 that promote full activation of lymphocytes. full activation of antigen - specific t cells requires two signals - one signal coming via the tcr and the other signal through engagment of co - stimulatary molecules. t cells receiving one signal via their tcr are turned off by mhc ( major histocompatibility complex ), via t cell cd28 binding to b7 on the dc induce tlymphokine and t cell proliferatiion
T細胞介導的細胞免疫在控制腫瘤生長方面發揮著重要作用, t細胞在發揮抗瘤效應(分泌細胞因子和直接殺傷)之前必須先經過活化,體內專職抗原提呈細胞( apc )細胞並使其活化,樹突狀細胞( dendriticcell , dc )為t細胞的激活提供雙重信號, t細胞藉助tcr識別由dcmhc分子遞交的抗原肽后,通過tcr - cd3復合體傳遞抗原特異性識別信號(第一信號) ,以cd28為主的t細胞表面輔佐分子識別dc表面b7分子,傳遞非特異性協同刺激信號(第二信號) ,在機體抗腫瘤免疫應答中處于核心地位。The present review describes the definition of immunotoxicity, the immunotoxicity test methods, the relation of pesticide and immune response and the immunotoxicity of pesticides in aquatic species, terrestrial species, mammals and human
論文介紹了農藥免疫毒性的概念,免疫毒性的檢驗方法,農藥與免疫應答,農藥對水生動物、陸生動物、哺乳動物以及人類免疫系統在體液免疫、細胞免疫、非特異性免疫等方面的影響。At present, in an attempt to stimulate specific antitumor immunity, experimental models and clinical studies are currently evaluating the potent antigen - presenting capacity of dc combined with single or multiple tumor antigen epitopes. however, there are several problems in utilizing pulsing dc with synthetic immunodominant peptides from identified antigens. 1 ) the potential induction of tolerance ; 2 ) the need to determine the patient ' s hla haplotype, the limitation of therapy to patients whose tumors express defined specific tumor antigens in the context of the correct hla phenotype, the unavailability of peptides for all hla haplotypes ; 3 ) the lack of cd4 help cell - related epitopes for most antigens ; and 4 ) the ctl resulting from such protocols have a good in vitro capacity to kill peptide - pulsed target cells but only a modest capacity to kill tumor cells
但是,學者們發現這一療法存在著如下的缺陷:單一ctl表位抗原肽的應用其抗腫瘤作用弱於多種腫瘤抗原的聯合應用,且有誘導免疫耐受的潛在危險,有時反而會促進腫瘤的生長;事先需對患者的hla單倍型進行鑒定,以確定ctl表位與hla單倍型是否匹配,目前尚缺乏能與所有hla單倍型相匹配的ctl表位,從而限制了這一療法的應用;這一療法所產生的ctl在體外能有效殺傷經腫瘤抗原肽共孵育過的靶細胞,但對腫瘤細胞的殺傷能力較弱:這種l表位抗原肽缺乏cd4汀h細胞相關的表位,因此,不能誘導有效的th細胞免疫應答。Dcs play a pivotal role in the development of antitumor immunity. t lymphocytes immune response induced by direct antigen - pulsed dcs can not maintain longer for peptides - mhc department or mhc molecules degeneration. the method of dcs loading with tumor antigen gene is another potential approach to enhancing and maintaining immune response
在用抗原直接刺激dc時,由於抗原- mhc復合物解離或細胞mhc分子降解而不能維持所誘導的t細胞免疫應答,藉助載體把腫瘤抗原基因導入dc后腫瘤抗原在dc內的持續表達能增強其抗原提呈能力並能維持所誘導的免疫效應。Dendritic cells ( dc ) are the most potent professional antigen - presenting cells ( apc ), required for the initiation of immune response. for all that the mechanism of dc functions are not fully elucidated
樹突狀細胞( dendriticcell , dc )是一種重要的專職抗原提呈細胞( apc ) ,具有刺激初始型t細胞增殖、啟動初次免疫應答的獨特功能,是t細胞免疫應答的直接啟動者和調控者。Up to now, clinical trails have been conducted in u. s. a. and europe to observe the antitumor effects of exosomes. exosomes may be a kind of potential vaccines for tumors in future. on the other hand, exosomes may be a kind of tolerogenic materials
為此,我們以一種c57bl / 6來源的3lllewis肺癌細胞系建立模型,用3ll細胞系和3ll腫瘤組織分泌的exosomes進行了體內和體外的功能實驗,並從t細胞免疫應答的角度初步探討了其作用的機制。Objectives to improve the effect of a single mtb8. 4 dna vaccine, we constructed a chimeric mtb8. 4 / hil - 12 eukaryotic plasmid by linkage of mycobacterium tuberculosis mtb8. 4 gene to human il12 gene with a simple linker ( gly4 - ser ) 3. we analyzed the immunogenicity of chimeric dna vaccine and investigated the immune responses elicited when mtb8. 4 / hil12 was presented as endogenous ag
目的:以il - 12作為分子佐劑,與結核桿菌新抗原mtb8 . 4基因連接形成嵌合分子,將其克隆到真核表達質粒中,構建成嵌合dna疫苗,研究其在小鼠體內誘導細胞免疫應答的效果及對c57bl 6n小鼠的免疫保護作用,為尋求安全、有效、廉價的結核病新疫苗打下基礎。To circumvent these deficits, novel antigen - delivery systems utilizing cytokine gene - modified tumor cells and dc or fusion of dc with tumor cells have resulted in induction of antitumor immunity. however, this u approach is difficult in some cases ( for example in breast cancer ) because only rarely has it been possible to isolate enough viable tumor cells from an individual to prepare the vaccine
為了克服上述缺陷,有學者採用滅活的腫瘤細胞、腫瘤抗原提取物(包括腫瘤細胞裂解物、 it na和洗脫肽等)沖擊致敏dc或將腫瘤細胞與dc融合后再回輸體內以激發機體的抗腫瘤免疫應答,也取得了較好的療效。The hla system plays an very important role in antigen identification and presentation, immune response and regulation, and is also one of the key factors that affect the result of organic transplantation and hematopoietic stem cell transplantation
Hla系統在抗原識別與呈遞、免疫應答與調控等方面起著極其重要的作用,是影響器官移植物長期存活和造血幹細胞移植成敗的關鍵因素之一。分享友人