脫氫皮質醇 的英文怎麼說
中文拼音 [tuōqīngpízhíchún]
脫氫皮質醇
英文
prednisolone base e/ bpmicro- 脫 : Ⅰ動詞1 (脫落) cast; shed; drop; fall off 2 (取下; 除去) take off; strip; cast off 3 (脫離) ...
- 氫 : 名詞[化學] (氣體元素) hydrogen (h)
- 皮 : Ⅰ名詞1 (人或物體表面的一層組織) skin 2 (皮革) leather; hide 3 (毛皮) fur 4 (包在外面的一層...
- 質 : Ⅰ名詞1 (性質; 本質) nature; character; essence 2 (質量) quality 3 (物質) matter; substance;...
- 醇 : Ⅰ名詞1 [書面語] (含酒精多的酒) mellow wine; good wine2 [化學] (有機化合物的一大類 含羥基的烴化...
- 皮質 : [生理學] cortex
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The principal adrenocortical products are aldosterone, cortisol and dehydroepiandrosterone sulphate.
腎上腺皮質的主要產物為醛固酮、皮質醇和脫氫異雄酮硫酸鹽。The 11 - hsd1 expression in the fetal brain also gradually increases with gestational age at late gestation and continues to increase in the hippocampus after birth until the 15th postnatal day, which shows a pattern very similar to th secretion. furthermore, previous data show injection of thyroxine ( t4 ) to normal newborn rats up - regulates gr expression in the hippocampus. these data suggest that the role of th in neural development may be partially ( if not all ) accomplished through regulating gc ' s activity
在海馬結構, 11 - hsd1與gr共存於同一海馬神經元內,主要呈現還原酶的特性,能使無活性的11 -脫氫皮質酮( a )可的松( e )轉化為有活性的皮質酮( b )皮質醇( f ) ,從而提高組織局部的糖皮質激素濃度,這樣, 11 - hsd1的存在就為親和力較低的gr發揮作用提供了前提條件。Gc binds to mr with higher affinity than gr. this gc - receptor interaction is also controlled at the pre - receptor level by two important factors : corticosteroid binding globulin ( cbg ) and 11 b - hydroxysteroid dehydrogenases ( 11 - hsds )
糖皮質激素與受體結合的量除與血漿中糖皮質激素水平、皮質醇結合蛋白( cbg )濃度有關外,還受到細胞內受體前糖皮質激素代謝酶? 11 -羥基類固醇脫氫酶( 11 - hsd )的調節。L l6 - hsd2 is localized to the sppytiotrophoblast of the placenty providing a fimctional barrier protecting the fetus from matemal glucocorticoids. a sequence resembling glucocorticoid response element ( gre ) has been identified in the promoter region of the human l l0 - hsdl gene. glucocorticoids have been shown to induce the expression of 11p - hsdl in the hippomus in vitro " whereas controversial results were obtained in the hepatocyte
體內至少存在兩型11 - hsd ,在細胞完整的狀態下, 11 - hsd1主要為還原酶,它活化gc的代謝產物17 -羥- 11 -脫氫皮質酮(嚙齒類為脫氫皮質酮)為有活性的皮質醇(嚙齒類為皮質酮) ,而11 - hsd2為氧化酶,它催化皮質醇為無活性的17 -羥- 11 -脫氫皮質酮,因此11 - hsd1加強gc的作用,而11 - hsd2減弱gc的作用。分享友人