innate immunity 中文意思是什麼
innate immunity
解釋
先天免疫, 天然免疫-
Thus, the complement system act as a link between innate and acquired immunity
因此，補體是連接機體天然免疫和獲得性免疫（ adaptiveimmunity ）的「橋梁」 。 -
We hope that our study will provide us with more comprehensive knowledge of the mechanisms of immune regulation and the roles that dc and complement play in innate and acquired immunity, as well as to lay a foundation for further exploration of the roles dc play in antigen - specific immune responses and immune tolerance from a new perspective. part i expression of complement receptors and complement - associated molecules on dendritic cells derived from distinct - origin at different stages of development two subsets of dendritic cells were generated from precursor cells isolated by means of magnetic cell separation system
曰補體受體及其相關分子在modc上的表達不同分化階段的單核細胞衍生性dc （ monocytes一deriveddc ， modc ）的誘導:將新鮮分離的單核細胞mo ，在含有gm一csf和工l一4培養體系中誘導5一7d ，即分化為未成熟modc ;對培養至sd的未成熟modc ，用tnfa刺激zd ，即分化為成熟modc ;此時再用lps刺激24h ，即為活化的modc 。 -
In view of the common property of dendritic cells and complement, namely their ability to link innate and acquired immunity, and with no reports, to date, addressing the direct effects of complement on the biological functions of dendritic cells, we decided to study the interaction between the complement system and dendritic cells
本研究的完成有助於在免疫應答的調控機制方面獲得新的認識，並對補體和dc在連接天然免疫和獲得性免疫之間的作用及相互關系能有更全面的理解，為進一步從新的角度和思路深入研究dc在抗原特異性免疫應答與免疫耐受中的作用及其機制奠定基礎。 -
Dendritic cells are characterized by their ability to efficiently present antigen, and are uniquely equipped to stimulate naive t cell responses. immature dendritic cells acquire antigens from throughout the peripheral body, then migrate to t - lymphocyte - dependent areas of lymph nodes. thus, dendritic cells act as bridges, operating at the interface of innate and acquired immunity
作為機體免疫系統中功能最強的專職性抗原提呈細胞（ antigen - presentingcells ， apc ） ，樹突狀細胞（ dendriticcells ， dc ）能高效地攝取、加工處理和提呈抗原，具有較強的遷移能力，並能顯著地激活初始型t細胞以啟動t細胞免疫應答反應，此外， dc與b細胞以及nk細胞等也存在著相互作用，可見， dc在連接天然免疫和獲得性免疫之間起著非常重要的作用。 -
It has been demonstrated that complement activating and cr2 cross - linking on b lymphocytes set up a bridge between innate and acquired immunity. the interaction of c3 and cd21 on b lymphocytes will benefit initiating immune response and regulating primary antibody response. cd21 / cd35 is important in the process of antibody avidity maturing, this is critical to b lymphocyte activation especially in the state of low antigen concentration
現己證實補體的活化以及b細胞表面crz的交聯在先天和獲得性免疫之間架起了重要的橋梁，表現為c3與b細胞cdzi的相互作用有利於啟動抗體應答反應，並對初級抗體應答反應有調節作用： cdzi cd35對于抗體的親和性成熟具有重要作用，在抗原濃度低的情況下，對于活化b細胞是至關重要的，而且mlgm （交聯有利於特異的低親和性b細胞對t細胞依賴性抗原和t細胞非依賴性抗原產生免疫應答。 -
Using proteomics and biological mass spectrometry as the main research methodologies, our primary research interests are to study proteome changes and signal transduction networking associated with infection and innate immunity
目前主要研究領域和興趣:本實驗室以蛋白質組學及生物質譜學為主要研究方法，重點研究感染與天然免疫過程中的蛋白組變化以及蛋白質信號傳導通路。 -
Natural autoantibody ( naa ) refers to antibodies that are present in the surum of healthy individuals in the absence of deliberate immunization with the targeted antigen. previous studies have showed that human immunity system includes a huge and complicated autoantibody repetoire. to date, several hundred naa have been found and proved to exist in normal individuals, including autoantibody targeted rbc, mhc, dna, transferrin, keratin, diphosphatidyglycerd, idiotype of igg, etc. naa, characterized by binding to various and nonspecific antigen, reacting rapidly, keeping conservative relatively, has been widely claimed to be an important constituted component of innate immunity. lt was proposed that the production of naa was related to positive selection of b lymphocytes
對naa的研究表明，健康人體免疫系統中存在著一個龐大而復雜的自身抗體網路。包括抗角蛋白自身抗體（ antikeratinautoantibody ， akautoab ）在內，迄今已經發現並證實的naa有數百種，如抗rbc 、 mhc 、 dna 、轉鐵蛋白、脂類和多糖的抗體以及jerne免疫調節網路中的抗獨特型抗體（ anti - idiotypeantibody ）等。由於個體出生即有naa ，且naa具有作用范圍廣、沒有特異的選擇性、反應出現快、有相對的穩定性等天然免疫的特點， naa被認為是天然免疫（ innateimmunity / naturalimmunity ）的重要組成部分。 -
In this course, evolutionary pathways that have led to the development of innate and adaptive immunity are analyzed, the conserved and unique features of the immune response from bacteria to higher vertebrates is traced, and factors, such as adaptive changes in pathogens that have shaped the evolution of immune system are identified
在本課程中，我們將分析天然免疫與適應性免疫發育的演化途徑，追蹤從細菌到高等脊椎動物共同與特有之免疫反應，以及辨識其他因子如對病原的適應而影響免疫系統的演化等。 -
Background : innate immunity system provide the body with its first line of protection against external injury and such a rapid, non - specific mechanism can almost be found all through the living kingdom. both cells and secreted molecules of innate immunity are dynamic in regard to their readiness status and the process of cell activation during the adaptive alteration of cell physiology at the initiation stage of innate immunity is addressed as acute phase response ( apr )
研究背景：幾乎所有動物受到創傷和感染等外界傷害時都會啟動急性反應系統（ acutephaseresponse ， arp ）進行快速的自我保護，包括抵禦微生物的入侵，促進創傷的修復，幫助機體恢復正常靜息狀態等，其中涉及眾多蛋白質（ app ）水平的變化。 -
Evolutionary genomics - based approaches for studies of insect innate immunity
進化基因組學在昆蟲天然免疫研究中的應用前景 -
Antibacterial peptides have been recognized as important mediators of innate immunity against microbes
抗菌肽是機體抵抗外源微生物入侵的第一道防線，在宿主先天免疫防禦機制中起重要作用。 -
The complement system, a key and conserved system of innate immunity, provides a rapid and efficient means of deleting invading microorganisms
補體（ complement ）作為天然免疫（ innateimmunity ）中的一類重要和保守的體系，為機體提供了快速和高效地清除入侵微生物的途徑。 -
Recently, antimicrobial peptides have received increasing attention as their fundamental role in host innate immunity defense mechanism. natural antifungal peptide is a potential candidate for the new antibiotics
作為生物機體免疫防禦分子的天然抗真菌多肽，引起人們極大關注，希望從中開發出新一代的生物類抗真菌藥物。 -
Defensins are cationic peptides, isolated from mammals, insets and plants and they serve as effect molecules of innate immunity, providing and efficient defense against infections pathogens. a novel antimicrobial peptide, human - defensin 3 ( ), was isolated and demonstrated a salt - insensitive broad spectrum of potent antimicrobial activity against many potentially pathogenic microbes
人-防禦素3 （ humanbeta - defensin3 ， h d - 3 ）是新近被克隆出來的第三種人源性-防禦素，它表現出了與其它幾種人-防禦素不同的特性和優越性，被認為具有獨特的研究和開發價值。
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