tumor-specific antigen 中文意思是什麼

tumor-specific antigen 解釋
腫瘤特異抗原
  • tumor : n. 【醫學】腫瘤，癌，疙瘩，贅疣。 a benign [malignant] tumor 良[惡]性腫瘤。adj. -ous 腫瘤的；誇張的 （tumorous growth 【農業】陡長）。
  • specific : adj 1 特殊的；特有的；特定的，專門的。2 明確的，具體的。3 【生物學】種的；【細菌】專性的。4 【醫...
  • antigen : n. 【醫學】抗原。
  1. Heat shock proteins ( hsps ) are molecular chaperones with potent adjuvant capability in the induction of antigen - specific ctl, thl response and increasing immunogenicity of tumor cells

    本課題應用a20腫瘤細胞，經熱休克作用，制備熱休克腫瘤細胞來源的exosomes 。
  2. At present, in an attempt to stimulate specific antitumor immunity, experimental models and clinical studies are currently evaluating the potent antigen - presenting capacity of dc combined with single or multiple tumor antigen epitopes. however, there are several problems in utilizing pulsing dc with synthetic immunodominant peptides from identified antigens. 1 ) the potential induction of tolerance ; 2 ) the need to determine the patient ' s hla haplotype, the limitation of therapy to patients whose tumors express defined specific tumor antigens in the context of the correct hla phenotype, the unavailability of peptides for all hla haplotypes ; 3 ) the lack of cd4 help cell - related epitopes for most antigens ; and 4 ) the ctl resulting from such protocols have a good in vitro capacity to kill peptide - pulsed target cells but only a modest capacity to kill tumor cells

    但是，學者們發現這一療法存在著如下的缺陷：單一ctl表位抗原肽的應用其抗腫瘤作用弱於多種腫瘤抗原的聯合應用，且有誘導免疫耐受的潛在危險，有時反而會促進腫瘤的生長；事先需對患者的hla單倍型進行鑒定，以確定ctl表位與hla單倍型是否匹配，目前尚缺乏能與所有hla單倍型相匹配的ctl表位，從而限制了這一療法的應用；這一療法所產生的ctl在體外能有效殺傷經腫瘤抗原肽共孵育過的靶細胞，但對腫瘤細胞的殺傷能力較弱：這種l表位抗原肽缺乏cd4汀h細胞相關的表位，因此，不能誘導有效的th細胞免疫應答。
  3. Dendritic cells ( dc ), the initiator and modulator of immune response, are the most powerful professional antigen - presenting cells ( apc ). recent studies indicated that dc have the most power to activate tumor specific ctl, therefore, dc are applied in the therapy of tumors, e

    機體的抗腫瘤免疫主要為t淋巴細胞所介導， t細胞的致敏、激活、擴增和對腫瘤細胞的殺傷作用均有賴于抗原遞呈細胞腫瘤遞呈相應的抗原肽及相關因子的參與。
  4. It delivers the false ? folding peptides for presentation to proteasomes in normal cells, while in tumor cells it acts as main tumor - resistant antigen, inducing specific immune response. recent research found that grp94 also relates with cell cycles, differentiation and apoptosis

    此外發現它還具有抗原提呈作用，在正常細胞中參與折疊錯誤蛋白到蛋白酶體的提呈；在腫瘤細胞中作為主要的腫瘤排斥抗原，引發針對該腫瘤細胞的特異性免疫反應。
  5. Conclusion : apoptotic - tumor - cell - loaded dc induced maturation by cd40mab could efficiently induce the activation and proliferation of tumor specific ctl, and the combination of il - 2, il - 15, cd28mab was a very powerful method to expand antigen specific ctl in vitro

    結論： cd40mab激發的凋亡腫瘤細胞負載dc在cd28mab 、 ilj和il上的聯合作用下可有效激活和擴增腫瘤特異性cth 。
  6. Objectives firstly to prepare the vaccine of human dcs and tumor cells transfectde with pcdna3 - cea, and to observe the induction of carcinoembryonic antigen ( cea ) - specific cytotoxic t - lymphocyte responses in vitro

    用脂質體將cea表達質粒轉染人dc ，觀察其對cea表達陽性的腫瘤的特異性免疫作用。
  7. Filamentous bacteriophage displayed tumor - specific antigen epitope mage - a1 induced cellular immune in mice

    展示腫瘤特異性抗原表位的噬菌體在小鼠體內引起的細胞免疫變化
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