細胞原癌基因 的英文怎麼說

中文拼音 [xìbāoyuánáijīyīn]
細胞原癌基因 英文
cellular proto-oncogene
  • 細 : 形容詞1 （條狀物橫剖面小） thin; slender 2 （顆粒小） in small particles; fine 3 （音量小） thin ...
  • 胞 : Ⅰ名詞1 （胞衣） afterbirth2 （同一個國家或民族的人） fellow countryman; compatriot Ⅱ形容詞（同胞...
  • 原 : Ⅰ形容詞1 （最初的; 原來的） primary; original; former 2 （沒有加工的） unprocessed; raw Ⅱ動詞（原...
  • 癌 : 名詞[醫學] （惡性腫瘤） cancer; carcinoma
  • 因 : Ⅰ動詞[書面語] （沿襲） follow; carry on Ⅱ介詞1 [書面語] （憑借; 根據） on the basis of; in accord...
  • 細胞 : cell; sytes; bioplast; cella; [口語] gene; [生物學] cellule; cellule cellulli cellulo ; cello ; k...
  1. " for their discovery of the cellular origin of retroviral oncogenes

    發現逆轉錄病毒原癌基因oncogene在細胞中的產生
  2. Established that proto - oncogenes play important roles in normal cellular control

    確立原癌基因在正常細胞調控中的重要作用
  3. In order to find an explanation and to determine the possible mechanism of these biological effects, many in vitro and in vivo studies of emf effects have been published. these studies were involved in many enzymes ( such as odc, succinate dehydrogenase, pkc ), pro - oncogene ( c - myc, c - fos, etc. ), gap junction and protein synthesis, and so on

    為了揭示工頻磁場生物效應的機制，尤其是與腫瘤發生發展的關系，人們開展了較為廣泛的體內及體外的實驗研究，涉及到各種生物酶類（ odc 、琥珀酸脫氫酶、 pkc等） 、原癌基因（ c - myc 、 c - fos等） 、細胞間縫隙連接及蛋白合成等方面。
  4. On the other hand, the activity and function of p27 kip1 was affected by many physiological agents such as camp, il - 2, rampamycin. the expression of p27kip1 increased after - irradiationin in the fibroblastoma cells, leading to arrest in gl phase, but its expression markedly decreased after y - irradiation in the nbcc cells, and leaded to arrest in g2 / m phase. several studies have reported that p27 kip1 involved in a much wider range of cellar processes, such as differentiation, apoptosis and migration, the expression level of p27kip1 is key for its function in dna damage responses

    另一方面， p27kip 』的活性水平及功能作用，因細胞類型不同而各異，又受多種因素的影響，如一些有絲分裂原camp 、雷帕黴素可以上調p27kip ，的表達，而il一2等則與p27ki 」 『的表達下降有關，受電離輻射（ ir ）照射的成纖維細胞瘤及用1 ， 25一二經基d3處理的hela細胞系在gl期均有游離的p27腳『的積累，細胞周期阻滯在gl期;而在痣癌伽bccs ）細胞中， y一射線能誘導p27吻『表達水平的顯著下調，細胞周期阻滯在g2艦期。
  5. For example, as a direct toxic effect, periodontal iruses and bacteria and their products ( endotoxins or enzymes, for example ) are toxic to surrounding cells and may directly induce mutations in tumor suppressor genes and proto - oncogenes or alter signaling pathways that affect cell proliferation or surial of epithelial cells

    例如，作為直接毒性作用，牙周病毒和細菌及在細胞周圍其產生的毒性物質（例如，類毒素或酶類）可直接誘導腫瘤抑制基因和原癌基因突變或者改變細胞信號傳導通路從而影響上皮細胞增殖或存活。
  6. For example, as a direct toxic effect, periodontal viruses and bacteria and their products ( endotoxins or enzymes, for example ) are toxic to surrounding cells and may directly induce mutations in tumor suppressor genes and proto - oncogenes or alter signaling pathways that affect cell proliferation or survival of epithelial cells

    例如，作為直接毒性作用，牙周病毒和細菌及在細胞周圍其產生的毒性物質（例如，類毒素或酶類）可直接誘導腫瘤抑制基因和原癌基因突變或者改變細胞信號傳導通路從而影響上皮細胞增殖或存活。
  7. Objective, clone tissue - type plasminogen activator ( t - pa ) gene and construct a new kind of recombinant vector containing human tissue - type plasminogon activator ( t - pa ) cnda neither cytotoxiaty nor actovating prot - oncogenes

    目的：克隆組織纖溶酶原激活物（ t - pa ）基因並構建一種無細胞毒性、不激活原癌基因的真核表達的pcdna3 . 1 （ + ） / t - pa質粒載體。
  8. It is known from studies using brefeldin a ( bfa ) that disruption of tgn can block the cytotoxicity of ricin, suggesting that the intracellular compartment may be an important part of the uptake pathway. ricin enters the cells by receptor - mediated endocytosis, followed by translocation across the membranes of intracellular organelles. in this study, a trans - golgi retention peptide signal yqrl was fused to the c - terminus of ricin a chain ( rta ) by polymerase chain reaction

    本實驗為重點研究反式高爾基體在毒素細胞內轉運過程中的作用，我們設計了一個反式高爾基體的靶向信號肽基因yqrl （ tyr - gln - arg - leu ）連接在rta分子的羧基端，用原核表達蛋白體系，純化並測定rta - yqrl與rta蛋白對hela （人宮頸癌細胞） ， wish （人羊膜上皮細胞） ， skov - 3 （人卵巢癌細胞）三種細胞的毒性作用。
  9. In order to further investigate the role of axudl in human tumor carcinogenesis and the potential association between the axudl gene expression status and the stimulation of transforming growth factor beta in human cancers, the present study was performed in three aspects as follows : ( 1 ) cloning full length enconding region cdna of axudl and construction of eukaryotic vector that expression the fusion protein of axud1 and influenza virus hemagglutin ha epitope tag ; ( 2 ) exploring the time and dose effects of tgf - 1 on the expression - of axudl gene in hepg2 hepatoma cells and spc - a1 lung carcinomas cells, and studying the effects of overexpression of axud1 on the expression of cell cycle and apoptosis related protein in hepg2 hepatoma cells ; ( 3 ) construction and expression of human axudl in e. coli m15. the following main results and conclusions can be obtained from the present study : 1. the full length ecnoding region of human axudl cdna from human peripheral blood lymphocytes was successfully cloned using one step rt - pcr method, and constructed into a eukaryotic expression vector which can be expressed a ha - axud1 fusion protein with axud1 and influenza virus hemagglutin ha epitope tag. the recombinant plasmid was identified by polymerase chain reaction, restriction endonuclease maping and sequencing, this expression vector might be instrumental to further study the function of axud1 protein in tumor cells

    為了進一步研究axud1在人類腫瘤發生中的作用及axud1基因的表達狀況與tgf -介導的信號通路的關系，本實驗研究分為三個部分： （ 1 ） axud1基因cdna全長編碼區的克隆和ha表位標記的axud1基因表達載體的構建； （ 2 ）探討肝癌細胞hepg2和肺腺癌spc - a1細胞中tgf - 1誘導的axud1基因表達的時間、劑量效應以及誘導表達的可能機理，並研究axud1的過表達對細胞周期和細胞凋亡相關蛋白表達的影響； （ 3 ） axud1原核表達載體的構建及其在大腸桿菌中的表達。本實驗的主要結果和結論如下： 1利用一步法rt - pcr成功地從人類外周血淋巴細胞中克隆出axud1基因編碼區cdna ，並將其構建入真核表達載體中，編碼的ha - axud1融合蛋白帶有流感病毒凝血素ha的表位標記肽段。
  10. Being a kind of adhesion molecules associating cells with extracellular matrix, integrins play a variety of roles in the process of invasion and metastasis in pancreatic adenocarcinoma

    胰腺癌手術切除率低死亡率高的重要原因之一是腫瘤早期即能發生局部浸潤和遠處器官轉移，整合素作為細胞與細胞外基質的黏附分子，在胰腺癌侵襲及轉移過程中發揮多重作用。
  11. Rapl belongs to ras superfamily of small gtp - binding proteins, which is considered to control cell growth, differentiation and survival. rapl was regarded as an antagonist of ras because it can revert the phenotype of oncogene ras transformed cells. recent researches show that rapl has its ras - independent functions in a variety of cellular systems besides its effect as an antagonist of ras

    Rap1除具有逆轉原癌基因ras激活突變體所導致的細胞形態改變而被認為是ras的拮抗物外，最近的研究還發現rap1在一系列的細胞系統中有獨立於ras之外的功能，如控制與細胞粘附有關的事件等，因而成為研究的熱點。
  12. Therefore, it is important to distinguish small cell carcinoma from other malignant tumors of the uterine cervix

    基於以上原因，將小細胞上皮癌與其他的子宮頸癌癥區別出來是相當重要的。
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