表型耐受 的英文怎麼說
中文拼音 [biǎoxíngnàishòu]
表型耐受
英文
phenotype tolerance-
On the other hand, there is substanial evidences tha dcs mediate tolerane. the gm - csf - stbolated mouse bone mwderived mhc class ii + dc progendors tha are deficient in cell surface erpression of the costbolatory molecules b7 - l and b7 - 2 can induce alloanginspecific t ceil anergy in vbo. systendc adchstraion of these donor - derived dc progendors to recipients intravenously 7 days before transplantation prolonged the median graft survival tane from 9. 5 days to 22 days wbout additional twnosuppressions in a mouse cardinc twlanation model
1995年， lul等報道表面缺乏共刺激分子，特別是缺乏cd80 （ b7 - 1 ）和cd86 （ b7 - 2 ）的未成熟型dc能在體外誘導同種抗原特異性的t細胞無能，而對dc的適當處理能夠使未成熟型dc潛在的耐受原性得以放大和增強，使得dc在誘導免疫耐受中具有相當重要的作用及潛在的應用價值。In contrast, transgenic mice overexpressing gat1 displayed ethanol tolerance, as shown by the righting reflex test. mi ce overexpressing gat1 survived a lethal dose of ethanol ( 9g / kg, i. p. ) longer, maintained locomotor activity longer after a sub - lethal dose ( 1. 75g / kg, i. p. )
相反，在翻正實驗中過量表達gat1的轉基因小鼠表現出顯著的酒精耐受；與同胎所生的野生型小鼠相比，轉基因小鼠在酒精緻死劑量（ 9g / kg ， i . p . ）下存活較長時間；在酒精低劑量（ 1 . 75g / kg ， i . p . ）下維持更長時間的運動活力，相應的ld50也較高。At present, in an attempt to stimulate specific antitumor immunity, experimental models and clinical studies are currently evaluating the potent antigen - presenting capacity of dc combined with single or multiple tumor antigen epitopes. however, there are several problems in utilizing pulsing dc with synthetic immunodominant peptides from identified antigens. 1 ) the potential induction of tolerance ; 2 ) the need to determine the patient ' s hla haplotype, the limitation of therapy to patients whose tumors express defined specific tumor antigens in the context of the correct hla phenotype, the unavailability of peptides for all hla haplotypes ; 3 ) the lack of cd4 help cell - related epitopes for most antigens ; and 4 ) the ctl resulting from such protocols have a good in vitro capacity to kill peptide - pulsed target cells but only a modest capacity to kill tumor cells
但是，學者們發現這一療法存在著如下的缺陷：單一ctl表位抗原肽的應用其抗腫瘤作用弱於多種腫瘤抗原的聯合應用，且有誘導免疫耐受的潛在危險，有時反而會促進腫瘤的生長；事先需對患者的hla單倍型進行鑒定，以確定ctl表位與hla單倍型是否匹配，目前尚缺乏能與所有hla單倍型相匹配的ctl表位，從而限制了這一療法的應用；這一療法所產生的ctl在體外能有效殺傷經腫瘤抗原肽共孵育過的靶細胞，但對腫瘤細胞的殺傷能力較弱：這種l表位抗原肽缺乏cd4汀h細胞相關的表位，因此，不能誘導有效的th細胞免疫應答。Abstract : plant responses to salt stress via a complex mechanism, including sensing and transducing the stress signal, activating the transcription factors and the corresponding metabolizing genes. since the whole mechanism is still unclear, this review emphasize the biochemical events during the plant adaptation to salt stress referring to an index of importance : the homeostasis in cytoplasm, the biosynthesis of osmolytes and the transport of water. most of these biochemical events were elucidated by study of halophyte and salt - sensitive mutations, also many important genes involved were cloned and used to generate stress - tolerance phenotypes in transgenic plants. on the other hand, about the molecular mechanism in signal transduction, the research of arabidopsis mutations and yeast functional complementation provided helpful traces but not full pathway
摘要植物對鹽脅迫的耐受反應是個復雜的過程，在分子水平上它包括對外界鹽信號的感應和傳遞，特異轉錄因子的激活和下游控制生理生化應答的效應基因的表達.在生化應答中，本文著重討論負責維持和重建離子平衡的膜轉運蛋白、滲調劑的生物合成和功能及水分控制.這些生理生化應答最終使得液泡中離子濃度升高和滲調劑在胞質中積累.近年來，通過對各種鹽生植物或鹽敏感突變株的研究，闡明了許多鹽應答的離子轉運途徑、水通道和物種特異的滲調劑代謝途徑，克隆了其相關基因並能在轉基因淡水植物中產生耐鹽表型;另一方面，在擬南芥突變體及利用酵母鹽敏感突變株功能互補篩選得到一些編碼信號傳遞蛋白的基因，這些都有助於闡明植物鹽脅迫應答的分子機制。The findings, which " need to be confirmed by other studies, " the investigator said, support other studies suggesting that hormonal contraceptives, particularly the more androgenic formulations, can alter glucose tolerance
這些結果， 「雖這需要其他研究證實， 」研究人員說，支持其他研究，表明了激素避孕藥，尤其是男性化作用更強的劑型，能夠改變妊娠婦女對葡萄糖耐受能力。The observaion tha sbolar cells were present in the nonlymphoid tissues of both rodents and humans, combined with early evidence tha they played an irnportant role in heart and kidney translan rejectio4 generated wr interest in dc
Dc在成熟過程中表型特徵和功能上均發生了很大的變化，未成熟型dc顯示出較強的致耐受活性，但是通常這種活性隨著dc的成熟而轉變為強大的免疫原性。分享友人