bicuculline 中文意思是什麼
bicuculline
解釋
比枯拉靈-
This study showed that the mt and sharpness of frequency tuning curves increased as the sound direction changed from contralateral to ipsilateral azimuthal angles. it suggests that sound direction effect on frequency tuning may be through the complex interplay between the excitatory and inhibitory inputs. the application of gaba ( a ) antagonist, bicuculline, lowered all mts but the application did not abolish direction - dependent variation in mt
聽皮層的抑制性影響使大多數神經元在蝙蝠最敏感的聲源方位c - 40的頻率分辨能力明顯提高，同時使c - 40和i - 40的最低閾值的差別進一步增大，提高了信噪比，提高下丘聽神經元對聲源方位和最佳頻率的分辨能力。 -
Distinct outward fpsc following the inward fpsc emerged in neurons ^ pll and was abolished by bicuculline ( 50 um ). bicuculline increased the amplitude and duration of the initial inward fpsc in all age groups and characteristically recruited the polysynaptic second component of fepscs in neurons p11 - p21. no spontaneous periodic inward current was detected in any age groups after blocking gabaa receptors
在生后11天以上的神經元，內向電流之後出現了明顯的外向電流，此外向電流可被gaba受體阻斷劑荷包牡丹堿（ 50pm ）完全阻斷，同時iscs的初始內向電流的幅值和時程均明顯增加，並且在阻斷gaba受體之後，任一年齡組均未觀察到自發性周期性的內向電流。 -
The rise time and half - decay time of the fast excitatory postsynaptic currents ( fepscs ), which were evoked in neurons ^ p6 in the presence of bicuculline ( 50 um ) alone or in combination with aps ( looum ), became slow with the postnatal development
在出生后6天以上，在有荷包牡丹堿或與aps同時存在的情況下所誘導的ipscs到達峰值的時程及半衰期均隨發育而延長。 -
Many researches supports that the dysfunction of pfc is crucial in schizophrenia and maybe it is related to gabaergic system : the reduced amount of gaba and gabaergic interneurons in pfc. the electrophysiological results shows 70 % neurons have increased activity but no significant increase in basic activity, half of silent neurons become activated in movement period after microinjection of bmi ( bicuculline methiodite ) into pfc
電生理學研究顯示：在前額葉皮層應用bmi （荷包牡丹堿）后70的神經元放電頻率增加，背景活性（基礎放電頻率）卻無顯著增加，而在運動期無放電活動的「安靜」神經元， ，給予bmi後有一半在運動期變得激活，說明gaba的抑制作用在行為的執行中可能非常重要。 -
B group : when only bicuculline was microinjected into pgl, map was significantly higher ; pulse pressure, hr, respiratory pressure and frequency of respiration did not change significantly. when bic was applied into pgl with ear acupuncture in pc simultaneously, compare with the former, map was not so much high ; the time of map came back to normal level, pulse pressure, hr, respiratory pressure and frequency of respiration did not change significantly
B組： pgl單獨微量注射荷包牡丹堿（ bic ） ， map升高，而脈壓、心率、呼吸壓、呼吸頻率無明顯改變； pgl注射bic並同時電針胸肺區，與單獨注射bic相比， map升高幅度得到明顯調整；對map恢復正常的時間、脈壓、心率、呼吸壓及呼吸頻率無明顯影響。 -
On the other hand, inhibitory areas of ftc could be abolished partially or completely during bicuculline application. these results showed that gabaergic inhibitory afferent projections to recorded neurons were activated by random resonance caused by weak noise in cochlea, which provided inhibitory input for sharpening frequency tuning and made neuron more precisely analyze sound signal near its bf. therefore, this experiment presented a possible evidence of cellular level for interpreting why human and animal could extract or capture sound signal of specific frequency from the environment with competing noise
說明山弱噪聲引起的耳蝸隨機共振在_ _仁行傳入過程中可能激活了至所一記錄的jc神經元的gaba能抑制性神經迴路，這種gaba能抑制為銳化神經元頻率調諧提供了一種抑制性輸入，使ic神經元對靠近最佳頻率的頻率分析變得更為細致和精確，由於聲頻率是聲信號的重要參數和信息載體，頻率調諧的銳化意味著對聲頻率分析能力增強，從而為解釋人們為什麼能從充滿噪聲的環境中捕捉或提取與行為學相關的信號提供了一種細胞水平的實驗證據。 -
2. b " group : when only bicuculline was microinjected into pgl, map was significantly higher ; pulse pressure, hr, respiratory pressure and frequency of respiration did not change significantly. when bic was applied into pgl with ear acupuncture in npc simultaneously, compare with the former, map was not so much high ; the time of map came back to normal level, pulse pressure, hr, respiratory pressure and frequency of respiration did not change significantly
B 』組： pgl單獨微量注射bic ， map升高，而脈壓、心率、呼吸壓、呼吸頻率無明顯改變； pgl注射bic並同時電針非胸肺區，與單獨注射bic相比， map升高幅度得到明顯調整；對map恢復正常的時間、脈壓、心率、呼吸壓及呼吸頻率無明顯影響。 -
The concomitant application of dl - 2 - amino - 5 - phosphonopentanoic acid ( aps, 100 jim ) with bicuculline did not eliminate the polysynaptic second component, but the second component was only elicited in slices in which the ca3 region was kept intact. moreover, the bicuculline - and ap5 - resistant second component was due to the burst activity of ca3 pyramidal neurons, which were antidromically excited by the stimulation of the schaffer collaterals
在生后1121天，神經元的快興奮性突觸后電流（ fstexcitatorypostsynapticcllntntsfepscs ）出現了典型的多突觸第二種成分，同時給予nmda受體阻斷劑aps不能消除此多突觸第二種成分，但其只有在ca3區保持完整的腦片上才可被引出。 -
In contrast, although application of bicuculline essentially had no effect on the bfs of ic neurons, it differentially broadened neurons ftcs at different azimuths abolishing the direction - dependent sharpening of frequency tuning
本研究還提示，聽皮層對下丘神經元頻率調諧的方向敏感性的調制，可能是通過改變神經元在不同聲源方位的抑制區的大小實現的。
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